Skip to main content
SpringerLink
Log in

The new trials of early goal-directed resuscitation: three-part harmony or disharmony?

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Rivers E, Nguyen B, Havstad S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19):1368–1377

    Article  PubMed  CAS  Google Scholar 

  2. Dellinger RP, Levy MM, Carlet JM et al (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36(1):296–327

    Article  PubMed  Google Scholar 

  3. Arnold RC, Shapiro NI, Jones AE et al (2009) Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 32(1):35–39

    Article  PubMed  CAS  Google Scholar 

  4. Ferrer R, Artigas A, Levy MM et al (2008) Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 299(19):2294–2303

    Article  PubMed  CAS  Google Scholar 

  5. Ferrer R, Artigas A, Suarez D et al (2009) Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. Am J Respir Crit Care Med 180(9):861–866

    Article  PubMed  CAS  Google Scholar 

  6. Gao F, Melody T, Daniels DF, Giles S, Fox S (2005) The impact of compliance with 6-h and 24-h sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care 9(6):R764–R770

    Article  PubMed  Google Scholar 

  7. Jones AE, Brown MD, Trzeciak S et al (2008) The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med 36(10):2734–2739

    Article  PubMed  Google Scholar 

  8. Jones AE, Focht A, Horton JM, Kline JA (2007) Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock. Chest 132(2):425–432

    Article  PubMed  Google Scholar 

  9. Levy MM, Dellinger RP, Townsend SR et al (2010) The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 38(2):367–374

    Article  PubMed  Google Scholar 

  10. Lin SM, Huang CD, Lin HC, Liu CY, Wang CH, Kuo HP (2006) A modified goal-directed protocol improves clinical outcomes in intensive care unit patients with septic shock: a randomized controlled trial. Shock 26(6):551–557

    Article  PubMed  Google Scholar 

  11. Micek ST, Roubinian N, Heuring T et al (2006) Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med 34(11):2707–2713

    Article  PubMed  Google Scholar 

  12. Nguyen HB, Corbett SW, Steele R et al (2007) Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 35(4):1105–1112

    Article  PubMed  Google Scholar 

  13. Zambon M, Ceola M, Almeida-de-Castro R, Gullo A, Vincent JL (2008) Implementation of the Surviving Sepsis Campaign guidelines for severe sepsis and septic shock: we could go faster. J Crit Care 23(4):455–460

    Article  PubMed  Google Scholar 

  14. Levy MM, Artigas A, Phillips GS et al (2012) Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis 12(12):919–924

    Article  PubMed  Google Scholar 

  15. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA (2010) Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 303(8):739–746

    Article  PubMed  CAS  Google Scholar 

  16. Kumar A (2010) Early antimicrobial therapy in severe sepsis and septic shock. Curr Infect Dis Rep 12(5):336–344

    Article  PubMed  Google Scholar 

  17. Kumar A, Roberts D, Wood KE et al (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34(6):1589–1596

    Article  PubMed  Google Scholar 

  18. Huang D (2013) Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intens Care Med. doi:10.1007/s00134-013-3024-7

    Google Scholar 

  19. Nichol AD, Egi M, Pettila V et al (2010) Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study. Crit Care 14(1):R25

    Google Scholar 

  20. De Backer D, Biston P, Devriendt J et al (2010) Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med 362(9):779–789

    Article  PubMed  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Centre for Heart Lung Innovation, St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada

    James A. Russell

  2. Department of Intensive Care, Erasme University Hospital, Route de Lennik 808 B, 1070, Brussels, Belgium

    Jean-Louis Vincent

Authors
  1. James A. Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean-Louis Vincent
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James A. Russell.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Russell, J.A., Vincent, JL. The new trials of early goal-directed resuscitation: three-part harmony or disharmony?. Intensive Care Med 39, 1867–1869 (2013). https://doi.org/10.1007/s00134-013-3068-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-013-3068-8

Search

Navigation