Skip to main content
SpringerLink
Log in

How to interpret a randomized controlled study stopped early

  • Statistical Note
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Joannes-Boyau O, Honoré P, Perez P et al (2013) High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicenter randomized controlled trial. Intens Care Med. doi:10.1007/s00134-013-2967-z

    Google Scholar 

  2. Friedlin B, Korn EL (2009) Stopping clinical trials early for benefit: impact on estimation. Clin Trials 6:119–125

    Article  Google Scholar 

  3. Sargent D (2009) Early stopping for benefit in National Cancer Institute-sponsored phase III trials: the system is working. J Clin Oncol 27(10):1543–1544

    Article  PubMed  Google Scholar 

  4. Korn EL, Friedlin B, Mooney M (2009) Stopping or reporting early for positive results in randomized clinical trials: the National Cancer Institute cooperative group experience from 1990 to 2005. J Clin Oncol 27(10):1712–1721

    Article  PubMed  CAS  Google Scholar 

  5. Montori VM, Devereaux PJ, Adhikari NKJ et al (2005) Randomized trials stopped early for benefit. A systematic review. JAMA 294(17):2203–2209

    Article  PubMed  CAS  Google Scholar 

  6. Berry SM, Carlin BP, Connor J (2010) Bias and trials stopped early for benefit. Letters to the Editor. JAMA 304(2):156–159

    Google Scholar 

  7. Ware JH, Muller JE, Braunwald E (1985) The futility index. An approach to cost-effective termination of randomized clinical trials. Am J Med 78(4):635–643

    Article  PubMed  CAS  Google Scholar 

  8. DeMets DL (2006) Futility approaches to interim monitoring by data monitoring committees. Clin Trial 3:522–529

    Article  Google Scholar 

Download references

Conflicts of interest

The author states that there is no conflict of interest.

Author information

Authors and Affiliations

  1. Gastroenterological Department, IRCCS “De Bellis” Hospital, Castellana Grotte, Italy

    G. Leandro

  2. UCL University College of London, London, UK

    G. Leandro

Authors
  1. G. Leandro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Leandro.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Leandro, G. How to interpret a randomized controlled study stopped early. Intensive Care Med 39, 1642–1643 (2013). https://doi.org/10.1007/s00134-013-3000-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-013-3000-2

Keywords

Search

Navigation