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Intensive Care Medicine

, Volume 39, Issue 6, pp 1157–1158 | Cite as

Severe adenoviral respiratory infection in children

  • Michael C. SpaederEmail author
Correspondence

Dear Editor,

Viral respiratory infections are a leading cause of illness and hospitalization in young children worldwide. Adenoviral respiratory tract infections occur primarily in infants and young children and can manifest as bronchiolitis, exacerbations of wheezing and asthma, croup, pneumonia and pneumonitis in transplant recipients [1]. We investigated the impact of adenovirus on morbidity and mortality outcomes in children with severe viral respiratory infection.

Following approval by our institutional review board, we performed a retrospective cohort study identifying all patients with laboratory-confirmed adenoviral respiratory infection admitted to the pediatric or cardiac intensive care unit (ICU) at our institution between January 2010 and May 2012. Infection was defined as the identification of adenovirus from a nasopharyngeal or endotracheal specimen by polymerase chain reaction testing.

There were 302 patients with laboratory-confirmed adenoviral respiratory infection...

Keywords

Acute Myeloid Leukemia Respiratory Syncytial Virus Pediatric Intensive Care Unit Cidofovir Croup 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

All work pertinent to this article was conducted at the Children’s National Medical Center, Washington, DC, USA.

Conflicts of interest

The author has no conflicts of interest or financial disclosures to declare.

References

  1. 1.
    Pavia AT (2011) Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis 52:S284–S289PubMedCrossRefGoogle Scholar
  2. 2.
    Thorburn K (2009) Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection. Arch Dis Child 94:99–103PubMedCrossRefGoogle Scholar
  3. 3.
    Randolph AG, Vaughn F, Sullivan R et al (2011) Critically ill children during the 2009–2010 influenza pandemic in the United States. Pediatrics 128:e1450PubMedCrossRefGoogle Scholar
  4. 4.
    Lynch JP, Fishbein M, Echavarria M (2011) Adenovirus. Semin Resp Crit Care Med 32:494–511CrossRefGoogle Scholar
  5. 5.
    Echavarria M (2008) Adenoviruses in immunocompromised hosts. Clin Microbiol Rev 21:704–715PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2013

Authors and Affiliations

  1. 1.Division of Critical Care MedicineChildren’s National Medical CenterWashingtonUSA

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