Heart transplantation for acute cardiac failure caused by thrombotic thrombocytopenic purpura (TTP)
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A 25-year-old woman with known Barlow disease and mitral regurgitation was hospitalized on 22 July 2011 (D1) after 4 days of fever and fatigue. Transesophageal echocardiography revealed mobile vegetation (20 × 0.5 mm) on the posterior mitral leaflet. Computed tomography scan showed two small spleen infarcts, but blood cultures were negative. Neurological examination was normal. Ceftriaxone, gentamicin, and doxycycline were started on D11. Severe acute mitral regurgitation led to pulmonary edema and valve replacement (bioprosthesis) on D21.
KeywordsLeft Ventricular Ejection Fraction Valve Replacement Plasma Exchange Thrombotic Thrombocytopenic Purpura ADAMTS13 Activity
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