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The diagnostic future for bloodstream infections?

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References

  1. Lehmann LE, Hunfeld KP, Steinbrucker M, Brade V, Book M, Seifert H, Bingold T, Hoeft A, Wissing H, Stüber F (2010) Improved detection of blood stream pathogens by real time PCR in severe sepsis. Intensive Care Med 36:49–56

    Article  CAS  PubMed  Google Scholar 

  2. Bloos F, Hinder F, Becker K, Sachse S, Mekontso Dessap A, Straube E, Cattoir V, Brun-Buisson C, Reinhart K, Peters G, Bauer M (2010) A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis. Intensive Care Med 36:241–247

    Article  CAS  PubMed  Google Scholar 

  3. Dark PM, Dean P, Warhurst G (2009) Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Crit Care 13:217

    Article  PubMed  Google Scholar 

  4. Libman E (1906) On some experiences with blood-cultures in the study of bacterial infections. Johns Hopkins Hosp Bull 17:215–228

    Google Scholar 

  5. Clinical and Laboratory Standards Institute (CLSI) (2007) Principles and procedures for blood cultures: approved guideline. CLSI documentM47-A (ISBN 1-56238-641-7). Clinical and Laboratory Standards Institute, Wayne

  6. Health Protection Agency (2005). Investigation of blood cultures (for organisms other than mycobacterium species). National Standard Method BSOP 37 Issue 5. http://www.hpa-standardmethods.org.uk/pdf_sops.asp

  7. Lee A, Mirrett S, Reller LB, Weinstein MP (2007) Detection of bloodstream infections in adults: how many blood cultures are needed? J Clin Microbiol 45:3546–3548

    Article  PubMed  Google Scholar 

  8. Cockerill FR 3rd, Wilson JW, Vetter EA, Goodman KM, Torgerson CA, Harmsen WS, Schleck CD, Ilstrup DM, Washington JA 2nd, Wilson WR (2004) Optimal testing parameters for blood cultures. Clin Infect Dis 38:1724–1730

    Article  PubMed  Google Scholar 

  9. Weinstein MP, Joho KL, Quartey SM (1994) Assessment of the value of the third blood culture: does it increase detection of bacteremia? Abstract. C-150. 94th General Meeting of the American Society for Microbiology, Las Vegas

  10. Weinstein MP, Reller LB, Murphy JR, Lichtenstein KA (1983) The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis 5:35–53

    CAS  PubMed  Google Scholar 

  11. Lehmann LE, Hunfeld KP, Emrich T, Haberhausen G, Wissing H, Hoeft A, Stüber F (2008) A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol 197:313–324

    Article  CAS  PubMed  Google Scholar 

  12. Handschur M, Karlic H, Hertel C, Pfeilstöcker M, Haslberger AG (2009) Preanalytic removal of human DNA eliminates false signals in general 16S rDNA PCR monitoring of bacterial pathogens in blood. Comp Immunol Microbiol Infect Dis 32:207–219

    Article  PubMed  Google Scholar 

  13. Falagas ME, Panayotis TT (2008) Enhanced and earlier detection of bacteremia and fungemia by multiplex polymerase chain reaction: how much enhanced, how much earlier and at what cost? Crit Care Med 36:1660–1661

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anaesthesia and Critical Care, Royal Blackburn Hospital, Haslingden Road, Blackburn, Lancashire, BB2 3HH, UK

    Paul Philip Dean

  2. School of Translational Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

    Paul Dark

  3. Department of Intensive Care Medicine, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK

    Paul Dark

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  1. Paul Philip Dean
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  2. Paul Dark
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Correspondence to Paul Philip Dean.

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Dean, P.P., Dark, P. The diagnostic future for bloodstream infections?. Intensive Care Med 37, 355–356 (2011). https://doi.org/10.1007/s00134-010-2062-7

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  • DOI: https://doi.org/10.1007/s00134-010-2062-7

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