Skip to main content
Log in

Lack of lung tissue penetration after intravenous colistimethate administration: reply to Imberti

  • Correspondence
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Imberti R (2010) Intravenous colistimethate administration and colistin lung tissue concentrations. Intensive Care Med 36. doi:10.1007/s00134-010-1960-z

  2. Lu Q, Girardi C, Zhang M, Bouhemad B, Louchahi K, Petitjean O, Wallet F, Becquemin MH, Le Naour G, Marquette CH, Rouby JJ (2010) Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa. Intensive Care Med 36:1147–1155. doi:10.1007/s00134-010-1879-4

    Article  CAS  PubMed  Google Scholar 

  3. Ziv G, Nouws JF, van Ginneken CA (1982) The pharmacokinetics and tissue levels of polymyxin B, colistin and gentamicin in calves. J Vet Pharmacol Ther 5:45–58

    Article  CAS  PubMed  Google Scholar 

  4. Nix DE, Goodwin SD, Peloquin CA, Rotella DL, Schentag JJ (1991) Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response. Antimicrob Agents Chemother 35:1953–1959

    CAS  PubMed  Google Scholar 

  5. Nix DE, Goodwin SD, Peloquin CA, Rotella DL, Schentag JJ (1991) Antibiotic tissue penetration and its relevance: models of tissue penetration and their meaning. Antimicrob Agents Chemother 35:1947–1952

    CAS  PubMed  Google Scholar 

  6. Bayat S, Louchahi K, Verdiere B, Anglade D, Rahoui A, Sorin PM, Tod M, Petitjean O, Fraisse F, Grimbert FA (2004) Comparison of 99mTc-DTPA and urea for measuring cefepime concentrations in epithelial lining fluid. Eur Respir J 24:150–156

    Article  CAS  PubMed  Google Scholar 

  7. Dudhani RV, Li J, Nation RL (2009) Plasma binding of colistin involves multiple proteins and is concentration dependant: potential clinical implications (abstract). In: 59th ICAAC, San Francisco, A1-576

  8. Imberti R, Cusato M, Villani P, Carnevale G, Lotti GA, Langer M, Regazzi M (2010) Steady-state pharmacokinetics and bronchoalveolar lavage concentration of colistin in critically ill patients after intravenous colistin methanesulphonate administration. Chest. doi:10.1378/chest.10-0463

  9. Kunin CM, Bugg A (1971) Binding of polymyxin antibiotics to tissues: the major determinant of distribution and persistence in the body. J Infect Dis 124:394–400

    CAS  PubMed  Google Scholar 

  10. Kunin CM (2009) The pharmacokinetics of polymyxin B are dependent on binding and release from deep-tissue compartments. Clin Infect Dis 48:842–843; Li J, Nation RL, Zavascki AP author reply 843–844

    Google Scholar 

  11. Tillement JP, Urien S, Chaumet-Riffaud P, Riant P, Bree F, Morin D, Albengres E, Barre J (1988) Blood binding and tissue uptake of drugs. Recent advances and perspectives. Fundam Clin Pharmacol 2:223–238

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Qin Lu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petitjean, O., Lu, Q. & Rouby, JJ. Lack of lung tissue penetration after intravenous colistimethate administration: reply to Imberti. Intensive Care Med 36, 1796–1797 (2010). https://doi.org/10.1007/s00134-010-1961-y

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-010-1961-y

Keywords

Navigation