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Prevention of acute kidney injury and protection of renal function in the intensive care unit

Expert opinion of the working group for nephrology, ESICM

  • Expert Panel
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Intensive Care Medicine Aims and scope Submit manuscript

An Erratum to this article was published on 23 February 2010

Abstract

Background

Acute renal failure on the intensive care unit is associated with significant mortality and morbidity.

Objectives

To determine recommendations for the prevention of acute kidney injury (AKI), focusing on the role of potential preventative maneuvers including volume expansion, diuretics, use of inotropes, vasopressors/vasodilators, hormonal interventions, nutrition, and extracorporeal techniques.

Method

A systematic search of the literature was performed for studies using these potential protective agents in adult patients at risk for acute renal failure/kidney injury between 1966 and 2009. The following clinical conditions were considered: major surgery, critical illness, sepsis, shock, and use of potentially nephrotoxic drugs and radiocontrast media. Where possible the following endpoints were extracted: creatinine clearance, glomerular filtration rate, increase in serum creatinine, urine output, and markers of tubular injury. Clinical endpoints included the need for renal replacement therapy, length of stay, and mortality. Studies are graded according to the international Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) group system

Conclusions and recommendations

Several measures are recommended, though none carries grade 1A. We recommend prompt resuscitation of the circulation with special attention to providing adequate hydration whilst avoiding high-molecular-weight hydroxy-ethyl starch (HES) preparations, maintaining adequate blood pressure using vasopressors in vasodilatory shock. We suggest using vasopressors in vasodilatory hypotension, specific vasodilators under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.

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References

  1. Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J (1998) Independent association between acute renal failure and mortality following cardiac surgery. Am J Med 104:343–348

    Article  CAS  PubMed  Google Scholar 

  2. Groeneveld AB, Tran DD, van der MJ, Nauta JJ, Thijs LG (1991) Acute renal failure in the medical intensive care unit: predisposing, complicating factors and outcome. Nephron 59:602–610

  3. Levy EM, Viscoli CM, Horwitz RI (1996) The effect of acute renal failure on mortality. A cohort analysis. JAMA 275:1489–1494

    Article  CAS  PubMed  Google Scholar 

  4. Metnitz PG, Krenn CG, Steltzer H, Lang T, Ploder J, Lenz K, Le G Jr, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058

    Article  PubMed  Google Scholar 

  5. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care 11:R31

    Article  PubMed  Google Scholar 

  6. Weisbord SD, Mor MK, Resnick AL, Hartwig KC, Sonel AF, Fine MJ, Palevsky PM (2008) Prevention, incidence, and outcomes of contrast-induced acute kidney injury. Arch Intern Med 168:1325–1332

    Article  PubMed  Google Scholar 

  7. Joannidis M, Metnitz PG (2005) Epidemiology and natural history of acute renal failure in the ICU. Crit Care Clin 21:239–249

    Article  PubMed  Google Scholar 

  8. Ricci Z, Cruz D, Ronco C (2008) The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 73:538–546

    Article  CAS  PubMed  Google Scholar 

  9. Morgera S, Schneider M, Neumayer HH (2008) Long-term outcomes after acute kidney injury. Crit Care Med 36:S193–S197

    Article  PubMed  Google Scholar 

  10. Cruz DN, Ronco C (2007) Acute kidney injury in the intensive care unit: current trends in incidence and outcome. Crit Care 11:149

    Article  PubMed  Google Scholar 

  11. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De BD, Kellum JA (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:R73

    Article  PubMed  Google Scholar 

  12. Joannidis M (2004) Drug-induced renal failure in the ICU. Int J Artif Organs 27:1034–1042

    CAS  PubMed  Google Scholar 

  13. Kellum JA (2008) Acute kidney injury. Crit Care Med 36:S141–S145

    Article  PubMed  Google Scholar 

  14. Lameire N, Van BW, Vanholder R (2008) Acute kidney injury. Lancet 372:1863–1865

    Article  PubMed  Google Scholar 

  15. Bagshaw SM, George C, Gibney RT, Bellomo R (2008) A multi-center evaluation of early acute kidney injury in critically ill trauma patients. Ren Fail 30:581–589

    Article  PubMed  Google Scholar 

  16. Cruz DN, Bolgan I, Perazella MA, Bonello M, de CM, Corradi V, Polanco N, Ocampo C, Nalesso F, Piccinni P, Ronco C (2007) North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI): targeting the problem with the RIFLE Criteria. Clin J Am Soc Nephrol 2:418–425

  17. Prescott GJ, Metcalfe W, Baharani J, Khan IH, Simpson K, Smith WC, MacLeod AM (2007) A prospective national study of acute renal failure treated with RRT: incidence, aetiology and outcomes. Nephrol Dial Transplant 22:2513–2519

    Article  PubMed  Google Scholar 

  18. Thakar CV, Arrigain S, Worley S, Yared JP, Paganini EP (2005) A clinical score to predict acute renal failure after cardiac surgery. J Am Soc Nephrol 16:162–168

    Article  PubMed  Google Scholar 

  19. Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G (2004) A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol 44:1393–1399

    PubMed  Google Scholar 

  20. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34:17–60

    Article  PubMed  Google Scholar 

  21. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O’Connell D, Oxman AD, Phillips B, Schunemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW Jr., Zaza S (2004) Grading quality of evidence and strength of recommendations. BMJ 19;328:1490

    Google Scholar 

  22. Guyatt G, Gutterman D, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G, Lewis SZ, Schunemann H (2006) Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American college of chest physicians task force. Chest 129:174–181

    Article  PubMed  Google Scholar 

  23. De Mendonca A, Vincent JL, Suter PM, Moreno R, Dearden NM, Antonelli M, Takala J, Sprung C, Cantraine F (2000) Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med 26:915–921

    Article  PubMed  Google Scholar 

  24. Guerin C, Girard R, Selli JM, Perdrix JP, Ayzac L (2000) Initial versus delayed acute renal failure in the intensive care unit. A multicenter prospective epidemiological study. Rhone-Alpes Area Study Group on Acute Renal Failure. Am J Respir Crit Care Med 161:872–879

    CAS  PubMed  Google Scholar 

  25. Schwilk B, Wiedeck H, Stein B, Reinelt H, Treiber H, Bothner U (1997) Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care. Intensive Care Med 23:1204–1211

    Article  CAS  PubMed  Google Scholar 

  26. Himmelfarb J, Joannidis M, Molitoris B, Schietz M, Okusa MD, Warnock D, Laghi F, Goldstein SL, Prielipp R, Parikh CR, Pannu N, Lobo SM, Shah S, D’Intini V, Kellum JA (2008) Evaluation and initial management of acute kidney injury. Clin J Am Soc Nephrol 3:962–967

    Article  PubMed  Google Scholar 

  27. Badr KF, Ichikawa I (1988) Prerenal failure: a deleterious shift from renal compensation to decompensation. N Engl J Med 319:623–629

    CAS  PubMed  Google Scholar 

  28. Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, de Boisblanc B, Connors AF Jr, Hite RD, Harabin AL (2006) Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354:2564–2575

    Article  CAS  PubMed  Google Scholar 

  29. Malbrain ML, Chiumello D, Pelosi P, Wilmer A, Brienza N, Malcangi V, Bihari D, Innes R, Cohen J, Singer P, Japiassu A, Kurtop E, De Keulenaer BL, Daelemans R, Del TM, Cosimini P, Ranieri M, Jacquet L, Laterre PF, Gattinoni L (2004) Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med 30:822–829

    Article  PubMed  Google Scholar 

  30. Wilkes NJ, Woolf R, Mutch M, Mallett SV, Peachey T, Stephens R, Mythen MG (2001) The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid–base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 93:811–816

    Article  CAS  PubMed  Google Scholar 

  31. Horgan KJ, Ottaviano YL, Watson AJ (1989) Acute renal failure due to mannitol intoxication. Am J Nephrol 9:106–109

    Article  CAS  PubMed  Google Scholar 

  32. Rozich JD, Paul RV (1989) Acute renal failure precipitated by elevated colloid osmotic pressure. Am J Med 87:359–360

    Article  CAS  PubMed  Google Scholar 

  33. Ahsan N, Palmer BF, Wheeler D, Greenlee RG Jr, Toto RD (1994) Intravenous immunoglobulin-induced osmotic nephrosis. Arch Intern Med 154:1985–1987

    Article  CAS  PubMed  Google Scholar 

  34. Coronel B, Mercatello A, Martin X, Lefrancois N (1997) Hydroxyethylstarch and renal function in kidney transplant recipients. Lancet 349:884

    Article  CAS  PubMed  Google Scholar 

  35. Legendre C, Thervet E, Page B, Percheron A, Noel LH, Kreis H (1993) Hydroxyethylstarch and osmotic-nephrosis-like lesions in kidney transplantation. Lancet 342:248–249

    Article  CAS  PubMed  Google Scholar 

  36. Horstick G, Lauterbach M, Kempf T, Bhakdi S, Heimann A, Horstick M, Meyer J, Kempski O (2002) Early albumin infusion improves global and local hemodynamics and reduces inflammatory response in hemorrhagic shock. Crit Care Med 30:851–855

    Article  CAS  PubMed  Google Scholar 

  37. Inoue M, Okajima K, Itoh K, Ando Y, Watanabe N, Yasaka T, Nagase S, Morino Y (1987) Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients. Kidney Int 32:198–203

    Article  CAS  PubMed  Google Scholar 

  38. Zhang H, Voglis S, Kim CH, Slutsky AS (2003) Effects of albumin and Ringer’s lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats. Crit Care Med 31:1515–1522

    Article  CAS  PubMed  Google Scholar 

  39. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350:2247–2256

    Article  CAS  PubMed  Google Scholar 

  40. Beyer R, Harmening U, Rittmeyer O, Zielmann S, Mielck F, Kazmaier S, Kettler D (1997) Use of modified fluid gelatin and hydroxyethyl starch for colloidal volume replacement in major orthopaedic surgery. Br J Anaesth 78:44–50

    CAS  PubMed  Google Scholar 

  41. Schortgen F, Lacherade JC, Bruneel F, Cattaneo I, Hemery F, Lemaire F, Brochard L (2001) Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study. Lancet 357:911–916

    Article  CAS  PubMed  Google Scholar 

  42. Mardel SN, Saunders FM, Allen H, Menezes G, Edwards CM, Ollerenshaw L, Baddeley D, Kennedy A, Ibbotson RM (1998) Reduced quality of clot formation with gelatin-based plasma substitutes. Br J Anaesth 80:204–207

    CAS  PubMed  Google Scholar 

  43. Tabuchi N, de HJ, Gallandat Huet RC, Boonstra PW, van OW (1995) Gelatin use impairs platelet adhesion during cardiac surgery. Thromb Haemost 74:1447–1451

  44. Kurnik BR, Singer F, Groh WC (1991) Case report: dextran-induced acute anuric renal failure. Am J Med Sci 302:28–30

    CAS  PubMed  Google Scholar 

  45. Laxenaire MC, Charpentier C, Feldman L (1994) Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicenter prospective study. Ann Fr Anesth Reanim 13:301–310

    CAS  PubMed  Google Scholar 

  46. Mailloux L, Swartz CD, Capizzi R, Kim KE, Onesti G, Ramirez O, Brest AN (1967) Acute renal failure after administration of low-molecular weight dextran. N Engl J Med 277:1113–1118

    Article  CAS  PubMed  Google Scholar 

  47. Messmer KF (1987) The use of plasma substitutes with special attention to their side effects. World J Surg 11:69–74

    Article  CAS  PubMed  Google Scholar 

  48. Bernard C, Alain M, Simone C, Xavier M, Jean-Francois M (1996) Hydroxyethylstarch and osmotic nephrosis-like lesions in kidney transplants. Lancet 348:1595

    Article  CAS  PubMed  Google Scholar 

  49. Bork K (2005) Pruritus precipitated by hydroxyethyl starch: a review. Br J Dermatol 152:3–12

    Article  CAS  PubMed  Google Scholar 

  50. Barron ME, Wilkes MM, Navickis RJ (2004) A systematic review of the comparative safety of colloids. Arch Surg 139:552–563

    Article  CAS  PubMed  Google Scholar 

  51. Wiedermann CJ (2004) Hydroxyethyl starch—can the safety problems be ignored? Wien Klin Wochenschr 116:583–594

    Article  CAS  PubMed  Google Scholar 

  52. Blasco V, Leone M, Antonini F, Geissler A, Albanese J, Martin C (2008) Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation. Br J Anaesth 100:504–508

    Article  CAS  PubMed  Google Scholar 

  53. Boldt J, Suttner S, Brosch C, Lehmann A, Rohm K, Mengistu A (2009) The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients. Intensive Care Med 35:462–470

    Article  PubMed  Google Scholar 

  54. Leuschner J, Opitz J, Winkler A, Scharpf R, Bepperling F (2003) Tissue storage of 14C-labelled hydroxyethyl starch (HES) 130/0.4 and HES 200/0.5 after repeated intravenous administration to rats. Drugs R D 4:331–338

    Article  CAS  PubMed  Google Scholar 

  55. Schortgen F, Girou E, Deye N, Brochard L (2008) The risk associated with hyperoncotic colloids in patients with shock. Intensive Care Med 34:2157–2168

    Article  PubMed  Google Scholar 

  56. Godet G, Lehot JJ, Janvier G, Steib A, De Castro, V, Coriat P (2008) Safety of HES 130/0.4 (Voluven(R)) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial. Eur J Anaesthesiol 20:1–9

    Google Scholar 

  57. Boldt J, Brosch C, Ducke M, Papsdorf M, Lehmann A (2007) Influence of volume therapy with a modern hydroxyethylstarch preparation on kidney function in cardiac surgery patients with compromised renal function: a comparison with human albumin. Crit Care Med 35:2740–2746

    Article  CAS  PubMed  Google Scholar 

  58. Sedrakyan A, Gondek K, Paltiel D, Elefteriades JA (2003) Volume expansion with albumin decreases mortality after coronary artery bypass graft surgery. Chest 123:1853–1857

    Article  PubMed  Google Scholar 

  59. Boldt J, Lehmann A, Rompert R, Haisch G, Isgro F (2000) Volume therapy with a new hydroxyethyl starch solution in cardiac surgical patients before cardiopulmonary bypass. J Cardiothorac Vasc Anesth 14:264–268

    Article  CAS  PubMed  Google Scholar 

  60. Boldt J, Brosch C, Rohm K, Lehmann A, Mengistu A, Suttner S (2008) Is albumin administration in hypoalbuminemic elderly cardiac surgery patients of benefit with regard to inflammation, endothelial activation, and long-term kidney function? Anesth Analg 107:1496–1503

    Article  CAS  PubMed  Google Scholar 

  61. Boldt J, Brosch C, Rohm K, Papsdorf M, Mengistu A (2008) Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients. Br J Anaesth 100:457–464

    Article  CAS  PubMed  Google Scholar 

  62. Dehne MG, Muhling J, Sablotzki A, Dehne K, Sucke N, Hempelmann G (2001) Hydroxyethyl starch (HES) does not directly affect renal function in patients with no prior renal impairment. J Clin Anesth 13:103–111

    Article  CAS  PubMed  Google Scholar 

  63. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377

    Article  CAS  PubMed  Google Scholar 

  64. Stockwell MA, Scott A, Day A, Riley B, Soni N (1992) Colloid solutions in the critically ill. A randomised comparison of albumin and polygeline 2. Serum albumin concentration and incidences of pulmonary oedema and acute renal failure. Anaesthesia 47:7–9

    Article  CAS  PubMed  Google Scholar 

  65. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K (2008) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358:125–139

    Article  CAS  PubMed  Google Scholar 

  66. Sakr Y, Payen D, Reinhart K, Sipmann FS, Zavala E, Bewley J, Marx G, Vincent JL (2007) Effects of hydroxyethyl starch administration on renal function in critically ill patients. Br J Anaesth 98:216–224

    Article  CAS  PubMed  Google Scholar 

  67. Solomon R, Werner C, Mann D, D’Elia J, Silva P (1994) Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents. N Engl J Med 331:1416–1420

    Article  CAS  PubMed  Google Scholar 

  68. Mueller C, Buerkle G, Buettner HJ, Petersen J, Perruchoud AP, Eriksson U, Marsch S, Roskamm H (2002) Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty. Arch Intern Med 162:329–336

    Article  CAS  PubMed  Google Scholar 

  69. Merten GJ, Burgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, Bersin RM, Van MA, Simonton CA III, Rittase RA, Norton HJ, Kennedy TP (2004) Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA 291:2328–2334

    Article  CAS  PubMed  Google Scholar 

  70. Ozcan EE, Guneri S, Akdeniz B, Akyildiz IZ, Senaslan O, Baris N, Aslan O, Badak O (2007) Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J 154:539–544

    Article  CAS  PubMed  Google Scholar 

  71. Masuda M, Yamada T, Mine T, Morita T, Tamaki S, Tsukamoto Y, Okuda K, Iwasaki Y, Hori M, Fukunami M (2007) Comparison of usefulness of sodium bicarbonate versus sodium chloride to prevent contrast-induced nephropathy in patients undergoing an emergent coronary procedure. Am J Cardiol 100:781–786

    Article  CAS  PubMed  Google Scholar 

  72. Briguori C, Airoldi F, D’Andrea D, Bonizzoni E, Morici N, Focaccio A, Michev I, Montorfano M, Carlino M, Cosgrave J, Ricciardelli B, Colombo A (2007) Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): a randomized comparison of 3 preventive strategies. Circulation 115:1211–1217

    CAS  PubMed  Google Scholar 

  73. Recio-Mayoral A, Chaparro M, Prado B, Cozar R, Mendez I, Banerjee D, Kaski JC, Cubero J, Cruz JM (2007) The reno-protective effect of hydration with sodium bicarbonate plus N-acetylcysteine in patients undergoing emergency percutaneous coronary intervention: the RENO Study. J Am Coll Cardiol 49:1283–1288

    Article  CAS  PubMed  Google Scholar 

  74. Hogan SE, L’Allier P, Chetcuti S, Grossman PM, Nallamothu BK, Duvernoy C, Bates E, Moscucci M, Gurm HS (2008) Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis. Am Heart J 156:414–421

    Article  CAS  PubMed  Google Scholar 

  75. Pakfetrat M, Nikoo MH, Malekmakan L, Tabandeh M, Roozbeh J, Nasab MH, Ostovan MA, Salari S, Kafi M, Vaziri NM, Adl F, Hosseini M, Khajehdehi P (2009) A comparison of sodium bicarbonate infusion versus normal saline infusion and its combination with oral acetazolamide for prevention of contrast-induced nephropathy: a randomized, double-blind trial. Int Urol Nephrol 41:629–634

    Article  CAS  PubMed  Google Scholar 

  76. Brar SS, Shen AY, Jorgensen MB, Kotlewski A, Aharonian VJ, Desai N, Ree M, Shah AI, Burchette RJ (2008) Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography: a randomized trial. JAMA 300:1038–1046

    Article  CAS  PubMed  Google Scholar 

  77. Maioli M, Toso A, Leoncini M, Gallopin M, Tedeschi D, Micheletti C, Bellandi F (2008) Sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. J Am Coll Cardiol 52:599–604

    Article  CAS  PubMed  Google Scholar 

  78. Adolph E, Holdt-Lehmann B, Chatterjee T, Paschka S, Prott A, Schneider H, Koerber T, Ince H, Steiner M, Schuff-Werner P, Nienaber CA (2008) Renal Insufficiency Following Radiocontrast Exposure Trial (REINFORCE): a randomized comparison of sodium bicarbonate versus sodium chloride hydration for the prevention of contrast-induced nephropathy. Coron Artery Dis 19:413–419

    PubMed  Google Scholar 

  79. Joannidis M, Schmid M, Wiedermann CJ (2008) Prevention of contrast media-induced nephropathy by isotonic sodium bicarbonate: a meta-analysis. Wien Klin Wochenschr 120:742–748

    Article  CAS  PubMed  Google Scholar 

  80. Navaneethan SD, Singh S, Appasamy S, Wing RE, Sehgal AR (2009) Sodium bicarbonate therapy for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. Am J Kidney Dis 53:617–627

    Article  CAS  PubMed  Google Scholar 

  81. Kanbay M, Covic A, Coca SG, Turgut F, Akcay A, Parikh CR (2009) Sodium bicarbonate for the prevention of contrast-induced nephropathy: a meta-analysis of 17 randomized trials. Int Urol Nephrol 41:617–627

    Article  CAS  PubMed  Google Scholar 

  82. Haase M, Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Reade MC, Bagshaw SM, Seevanayagam N, Seevanayagam S, Doolan L, Buxton B, Dragun D (2009) Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med 37:39–47

    Article  CAS  PubMed  Google Scholar 

  83. Branch RA (1988) Prevention of amphotericin B-induced renal impairment. A review on the use of sodium supplementation. Arch Intern Med 148:2389–2394

    Article  CAS  PubMed  Google Scholar 

  84. Cheung TW, Jayaweera DT, Pearce D, Benson P, Nahass R, Olson C, Wool GM (2000) Safety of oral versus intravenous hydration during induction therapy with intravenous foscarnet in AIDS patients with cytomegalovirus infections. Int J STD AIDS 11:640–647

    Article  CAS  PubMed  Google Scholar 

  85. Safrin S, Cherrington J, Jaffe HS (1999) Cidofovir. Review of current and potential clinical uses. Adv Exp Med Biol 458:111-20: 111-120

    Google Scholar 

  86. Perazella MA (1999) Crystal-induced acute renal failure. Am J Med 106:459–465

    Article  CAS  PubMed  Google Scholar 

  87. Bagshaw SM, Delaney A, Jones D, Ronco C, Bellomo R (2007) Diuretics in the management of acute kidney injury: a multinational survey. Contrib Nephrol 156:236–49: 236–249

    Google Scholar 

  88. Bayati A, Nygren K, Kallskog O, Wolgast M (1990) The effect of loop diuretics on the long-term outcome of post-ischaemic acute renal failure in the rat. Acta Physiol Scand 139:271–279

    Article  CAS  PubMed  Google Scholar 

  89. Heyman SN, Rosen S, Epstein FH, Spokes K, Brezis ML (1994) Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int 45:981–985

    Article  CAS  PubMed  Google Scholar 

  90. Kramer HJ, Schuurmann J, Wassermann C, Dusing R (1980) Prostaglandin-independent protection by furosemide from oliguric ischemic renal failure in conscious rats. Kidney Int 17:455–464

    Article  CAS  PubMed  Google Scholar 

  91. Stevens MA, McCullough PA, Tobin KJ, Speck JP, Westveer DC, Guido-Allen DA, Timmis GC, O’Neill WW (1999) A prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy: results of the P.R.I.N.C.E. Study. Prevention of Radiocontrast Induced Nephropathy Clinical Evaluation. J Am Coll Cardiol 33:403–411

    Article  CAS  PubMed  Google Scholar 

  92. Weinstein JM, Heyman S, Brezis M (1992) Potential deleterious effect of furosemide in radiocontrast nephropathy. Nephron 62:413–415

    Article  CAS  PubMed  Google Scholar 

  93. Brown CB, Ogg CS, Cameron JS (1981) High dose frusemide in acute renal failure: a controlled trial. Clin Nephrol 15:90–96

    CAS  PubMed  Google Scholar 

  94. Lassnigg A, Donner E, Grubhofer G, Presterl E, Druml W, Hiesmayr M (2000) Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. J Am Soc Nephrol 11:97–104

    CAS  PubMed  Google Scholar 

  95. Cotter G, Weissgarten J, Metzkor E, Moshkovitz Y, Litinski I, Tavori U, Perry C, Zaidenstein R, Golik A (1997) Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure. Clin Pharmacol Ther 62:187–193

    Article  CAS  PubMed  Google Scholar 

  96. Hager B, Betschart M, Krapf R (1996) Effect of postoperative intravenous loop diuretic on renal function after major surgery. Schweiz Med Wochenschr 126:666–673

    Google Scholar 

  97. van der Voort PHJ, Boerma EC, Koopmans M, Zandberg M, de RJ, Gerritsen RT, Egbers PH, Kingma WP, Kuiper MA (2009) Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial. Crit Care Med 37:533–538

    Google Scholar 

  98. Shilliday IR, Quinn KJ, Allison ME (1997) Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study. Nephrol Dial Transplant 12:2592–2596

    Article  CAS  PubMed  Google Scholar 

  99. Sirivella S, Gielchinsky I, Parsonnet V (2000) Mannitol, furosemide, and dopamine infusion in postoperative renal failure complicating cardiac surgery. Ann Thorac Surg 69:501–506

    Article  CAS  PubMed  Google Scholar 

  100. Ho KM, Sheridan DJ (2006) Meta-analysis of frusemide to prevent or treat acute renal failure. BMJ 333:420

    Article  CAS  PubMed  Google Scholar 

  101. Bagshaw SM, Delaney A, Haase M, Ghali WA, Bellomo R (2007) Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis. Crit Care Resusc 9:60–68

    PubMed  Google Scholar 

  102. Sampath S, Moran JL, Graham PL, Rockliff S, Bersten AD, Abrams KR (2007) The efficacy of loop diuretics in acute renal failure: assessment using Bayesian evidence synthesis techniques. Crit Care Med 35:2516–2524

    Article  CAS  PubMed  Google Scholar 

  103. Mehta RL, Pascual MT, Soroko S, Chertow GM (2002) Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 288:2547–2553

    Article  CAS  PubMed  Google Scholar 

  104. Uchino S, Doig GS, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Nacedo E, Gibney N, Tolwani A, Ronco C, Kellum JA (2004) Diuretics and mortality in acute renal failure. Crit Care Med 32:1669–1677

    Article  PubMed  Google Scholar 

  105. Dünser MW, Takala J, Ulmer H, Mayr VD, Luckner G, Jochberger S, Daudel F, Lepper P, Hasibeder WR, Jakob SM (2009) Arterial blood pressure during early sepsis and outcome. Intensive Care Med 35:1225–1233

    Article  PubMed  Google Scholar 

  106. Bourgoin A, Leone M, Delmas A, Garnier F, Albanese J, Martin C (2005) Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function. Crit Care Med 33:780–786

    Article  CAS  PubMed  Google Scholar 

  107. Holmes CL, Walley KR (2003) Bad medicine: low-dose dopamine in the ICU. Chest 123:1266–1275

    Article  CAS  PubMed  Google Scholar 

  108. Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J (2000) Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 356:2139–2143

    Article  CAS  PubMed  Google Scholar 

  109. Friedrich JO, Adhikari N, Herridge MS, Beyene J (2005) Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142:510–524

    CAS  PubMed  Google Scholar 

  110. Girbes AR, Patten MT, McCloskey BV, Groeneveld AB, Hoogenberg K (2000) The renal and neurohumoral effects of the addition of low-dose dopamine in septic critically ill patients. Intensive Care Med 26:1685–1689

    Article  CAS  PubMed  Google Scholar 

  111. Ichai C, Soubielle J, Carles M, Giunti C, Grimaud D (2000) Comparison of the renal effects of low to high doses of dopamine and dobutamine in critically ill patients: a single-blind randomized study. Crit Care Med 28:921–928

    Article  CAS  PubMed  Google Scholar 

  112. Karthik S, Lisbon A (2006) Low-dose dopamine in the intensive care unit. Semin Dial 19:465–471

    Article  PubMed  Google Scholar 

  113. Renton MC, Snowden CP (2005) Dopexamine and its role in the protection of hepatosplanchnic and renal perfusion in high-risk surgical and critically ill patients. Br J Anaesth 94:459–467

    Article  CAS  PubMed  Google Scholar 

  114. Albanese J, Leone M, Garnier F, Bourgoin A, Antonini F, Martin C (2004) Renal effects of norepinephrine in septic and nonseptic patients. Chest 126:534–539

    Article  CAS  PubMed  Google Scholar 

  115. Delmas A, Leone M, Rousseau S, Albanese J, Martin C (2005) Clinical review: Vasopressin and terlipressin in septic shock patients. Crit Care 9:212–222

    Article  PubMed  Google Scholar 

  116. Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D (2008) Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:877–887

    Article  CAS  PubMed  Google Scholar 

  117. Brezis M, Rosen S (1995) Hypoxia of the renal medulla—its implications for disease. N Engl J Med 332:647–655

    Article  CAS  PubMed  Google Scholar 

  118. Cohen RI, Hassell AM, Marzouk K, Marini C, Liu SF, Scharf SM (2001) Renal effects of nitric oxide in endotoxemia. Am J Respir Crit Care Med 164:1890–1895

    CAS  PubMed  Google Scholar 

  119. Lameire NH, Matthys E, Kesteloot D, Waterloos MA (1990) Effect of a serotonin blocking agent on renal hemodynamics in the normal rat. Kidney Int 38:823–829

    Article  CAS  PubMed  Google Scholar 

  120. Linas S, Whittenburg D, Repine JE (1997) Nitric oxide prevents neutrophil-mediated acute renal failure. Am J Physiol 272:F48–F54

    CAS  PubMed  Google Scholar 

  121. Zhang H, Rogiers P, Smail N, Cabral A, Preiser JC, Peny MO, Vincent JL (1997) Effects of nitric oxide on blood flow distribution and O2 extraction capabilities during endotoxic shock. J Appl Physiol 83:1164–1173

    CAS  PubMed  Google Scholar 

  122. Brienza N, Malcangi V, Dalfino L, Trerotoli P, Guagliardi C, Bortone D, Faconda G, Ribezzi M, Ancona G, Bruno F, Fiore T (2006) A comparison between fenoldopam and low-dose dopamine in early renal dysfunction of critically ill patients. Crit Care Med 34:707–714

    Article  CAS  PubMed  Google Scholar 

  123. Morelli A, Ricci Z, Bellomo R, Ronco C, Rocco M, Conti G, De GA, Picchini U, Orecchioni A, Portieri M, Coluzzi F, Porzi P, Serio P, Bruno A, Pietropaoli P (2005) Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trial. Crit Care Med 33:2451–2456

    Article  CAS  PubMed  Google Scholar 

  124. Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw AD (2005) Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 46:26–34

    Article  CAS  PubMed  Google Scholar 

  125. Landoni G, Biondi-Zoccai GG, Marino G, Bove T, Fochi O, Maj G, Calabro MG, Sheiban I, Tumlin JA, Ranucci M, Zangrillo A (2008) Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis. J Cardiothorac Vasc Anesth 22:27–33

    Article  CAS  PubMed  Google Scholar 

  126. Landoni G, Biondi-Zoccai GG, Tumlin JA, Bove T, De LM, Calabro MG, Ranucci M, Zangrillo A (2007) Beneficial impact of fenoldopam in critically ill patients with or at risk for acute renal failure: a meta-analysis of randomized clinical trials. Am J Kidney Dis 49:56–68

    Article  CAS  PubMed  Google Scholar 

  127. Allaqaband S, Tumuluri R, Malik AM, Gupta A, Volkert P, Shalev Y, Bajwa TK (2002) Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy. Catheter Cardiovasc Interv 57:279–283

    Article  PubMed  Google Scholar 

  128. Stone GW, McCullough PA, Tumlin JA, Lepor NE, Madyoon H, Murray P, Wang A, Chu AA, Schaer GL, Stevens M, Wilensky RL, O’Neill WW (2003) Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial. JAMA 290:2284–2291

    Article  CAS  PubMed  Google Scholar 

  129. Kulka PJ, Tryba M, Zenz M (1996) Preoperative alpha2-adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: results of a randomized, controlled trial. Crit Care Med 24:947–952

    Article  CAS  PubMed  Google Scholar 

  130. Myles PS, Hunt JO, Holdgaard HO, McRae R, Buckland MR, Moloney J, Hall J, Bujor MA, Esmore DS, Davis BB, Morgan DJ (1999) Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery. Anaesth Intensive Care 27:137–147

    CAS  PubMed  Google Scholar 

  131. Sward K, Valsson F, Sellgren J, Ricksten SE (2005) Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humans. Intensive Care Med 31:79–85

    Article  PubMed  Google Scholar 

  132. Allgren RL, Marbury TC, Rahman SN, Weisberg LS, Fenves AZ, Lafayette RA, Sweet RM, Genter FC, Kurnik BR, Conger JD, Sayegh MH (1997) Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group. N Engl J Med 336:828–834

    Article  CAS  PubMed  Google Scholar 

  133. Lewis J, Salem MM, Chertow GM, Weisberg LS, McGrew F, Marbury TC, Allgren RL (2000) Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. Am J Kidney Dis 36:767–774

    Article  CAS  PubMed  Google Scholar 

  134. Rahman SN, Kim GE, Mathew AS, Goldberg CA, Allgren R, Schrier RW, Conger JD (1994) Effects of atrial natriuretic peptide in clinical acute renal failure. Kidney Int 45:1731–1738

    Article  CAS  PubMed  Google Scholar 

  135. Meyer M, Pfarr E, Schirmer G, Uberbacher HJ, Schope K, Bohm E, Fluge T, Mentz P, Scigalla P, Forssmann WG (1999) Therapeutic use of the natriuretic peptide ularitide in acute renal failure. Ren Fail 21:85–100

    Article  CAS  PubMed  Google Scholar 

  136. Sward K, Valsson F, Odencrants P, Samuelsson O, Ricksten SE (2004) Recombinant human atrial natriuretic peptide in ischemic acute renal failure: a randomized placebo-controlled trial. Crit Care Med 32:1310–1315

    Article  PubMed  CAS  Google Scholar 

  137. Mentzer RM Jr, Oz MC, Sladen RN, Graeve AH, Hebeler RF Jr, Luber JM Jr, Smedira NG (2007) Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery: the NAPA trial. J Am Coll Cardiol 49:716–726

    Article  CAS  PubMed  Google Scholar 

  138. Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T (2008) Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 36:745–751

    Article  CAS  PubMed  Google Scholar 

  139. Chen HH, Sundt TM, Cook DJ, Heublein DM, Burnett JC Jr (2007) Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery: a double-blind placebo-controlled pilot study. Circulation 116:I134–I138

    Article  CAS  PubMed  Google Scholar 

  140. Sackner-Bernstein JD, Kowalski M, Fox M, Aaronson K (2005) Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials. JAMA 293:1900–1905

    Article  CAS  PubMed  Google Scholar 

  141. Abizaid AS, Clark CE, Mintz GS, Dosa S, Popma JJ, Pichard AD, Satler LF, Harvey M, Kent KM, Leon MB (1999) Effects of dopamine and aminophylline on contrast-induced acute renal failure after coronary angioplasty in patients with preexisting renal insufficiency. Am J Cardiol 83:260–263 A5

    Article  CAS  PubMed  Google Scholar 

  142. Bagshaw SM, Ghali WA (2005) Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. Arch Intern Med 165:1087–1093

    Article  PubMed  Google Scholar 

  143. Erley CM, Duda SH, Schlepckow S, Koehler J, Huppert PE, Strohmaier WL, Bohle A, Risler T, Osswald H (1994) Adenosine antagonist theophylline prevents the reduction of glomerular filtration rate after contrast media application. Kidney Int 45:1425–1431

    Article  CAS  PubMed  Google Scholar 

  144. Erley CM, Duda SH, Rehfuss D, Scholtes B, Bock J, Muller C, Osswald H, Risler T (1999) Prevention of radiocontrast-media-induced nephropathy in patients with pre-existing renal insufficiency by hydration in combination with the adenosine antagonist theophylline. Nephrol Dial Transplant 14:1146–1149

    Article  CAS  PubMed  Google Scholar 

  145. Huber W, Ilgmann K, Page M, Hennig M, Schweigart U, Jeschke B, Lutilsky L, Weiss W, Salmhofer H, Classen M (2002) Effect of theophylline on contrast material-nephropathy in patients with chronic renal insufficiency: controlled, randomized, double-blinded study. Radiology 223:772–779

    Article  CAS  PubMed  Google Scholar 

  146. Huber W, Schipek C, Ilgmann K, Page M, Hennig M, Wacker A, Schweigart U, Lutilsky L, Valina C, Seyfarth M, Schomig A, Classen M (2003) Effectiveness of theophylline prophylaxis of renal impairment after coronary angiography in patients with chronic renal insufficiency. Am J Cardiol 91:1157–1162

    Article  CAS  PubMed  Google Scholar 

  147. Ix JH, McCulloch CE, Chertow GM (2004) Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis. Nephrol Dial Transplant 19:2747–2753

    Article  CAS  PubMed  Google Scholar 

  148. Kapoor A, Kumar S, Gulati S, Gambhir S, Sethi RS, Sinha N (2002) The role of theophylline in contrast-induced nephropathy: a case–control study. Nephrol Dial Transplant 17:1936–1941

    Article  CAS  PubMed  Google Scholar 

  149. Katholi RE, Taylor GJ, McCann WP, Woods WT Jr, Womack KA, McCoy CD, Katholi CR, Moses HW, Mishkel GJ, Lucore CL (1995) Nephrotoxicity from contrast media: attenuation with theophylline. Radiology 195:17–22

    CAS  PubMed  Google Scholar 

  150. Kolonko A, Wiecek A, Kokot F (1998) The nonselective adenosine antagonist theophylline does prevent renal dysfunction induced by radiographic contrast agents. J Nephrol 11:151–156

    CAS  PubMed  Google Scholar 

  151. Huber W, Eckel F, Hennig M, Rosenbrock H, Wacker A, Saur D, Sennefelder A, Hennico R, Schenk C, Meining A, Schmelz R, Fritsch R, Weiss W, Hamar P, Heemann U, Schmid RM (2006) Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study. Radiology 239:793–804

    Article  PubMed  Google Scholar 

  152. Kelly AM, Dwamena B, Cronin P, Bernstein SJ, Carlos RC (2008) Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Ann Intern Med 148:284–294

    PubMed  Google Scholar 

  153. Kleinschmidt S, Bauer M, Grundmann U, Schneider A, Wagner B, Graeter T (1997) Effect of gamma-hydroxybutyric acid and pentoxifylline on kidney function parameters in coronary surgery interventions. Anaesthesiol Reanim 22:102–107

    CAS  PubMed  Google Scholar 

  154. Boldt J, Brosch C, Piper SN, Suttner S, Lehmann A, Werling C (2001) Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients. Crit Care Med 29:952–958

    Article  CAS  PubMed  Google Scholar 

  155. Hoffmann H, Markewitz A, Kreuzer E, Reichert K, Jochum M, Faist E (1998) Pentoxifylline decreases the incidence of multiple organ failure in patients after major cardio-thoracic surgery. Shock 9:235–240

    Article  CAS  PubMed  Google Scholar 

  156. Boldt J, Brosch C, Suttner S, Piper SN, Lehmann A, Werling C (2002) Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. Intensive Care Med 28:1462–1469

    Article  PubMed  Google Scholar 

  157. Boldt J, Brosch C, Lehmann A, Suttner S, Isgro F (2004) The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients. Anesth Analg 99:1009–1017 (table)

    Article  CAS  PubMed  Google Scholar 

  158. Yilmaz MB, Yalta K, Yontar C, Karadas F, Erdem A, Turgut OO, Yilmaz A, Tandogan I (2007) Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine. Cardiovasc Drugs Ther 21:431–435

    Article  CAS  PubMed  Google Scholar 

  159. Sketch MH Jr, Whelton A, Schollmayer E, Koch JA, Bernink PJ, Woltering F, Brinker J (2001) Prevention of contrast media-induced renal dysfunction with prostaglandin E1: a randomized, double-blind, placebo-controlled study. Am J Ther 8:155–162

    Article  PubMed  Google Scholar 

  160. Koch JA, Plum J, Grabensee B, Modder U (2000) Prostaglandin E1: a new agent for the prevention of renal dysfunction in high risk patients caused by radiocontrast media? PGE1 Study Group. Nephrol Dial Transplant 15:43–49

    Article  CAS  PubMed  Google Scholar 

  161. Spargias K, Adreanides E, Giamouzis G, Karagiannis S, Gouziouta A, Manginas A, Voudris V, Pavlides G, Cokkinos DV (2006) Iloprost for prevention of contrast-mediated nephropathy in high-risk patients undergoing a coronary procedure. Results of a randomized pilot study. Eur J Clin Pharmacol 62:589–595

    Article  CAS  PubMed  Google Scholar 

  162. Norman JT, Stidwill R, Singer M, Fine LG (2003) Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action. Nephron Physiol 94:39–46

    Article  Google Scholar 

  163. Tiefenbacher CP, Friedrich S, Bleeke T, Vahl C, Chen X, Niroomand F (2004) ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles. Am J Physiol Heart Circ Physiol 286:H1425–H1432

    Article  CAS  PubMed  Google Scholar 

  164. Ryckwaert F, Colson P, Ribstein J, Boccara G, Guillon G (2001) Haemodynamic and renal effects of intravenous enalaprilat during coronary artery bypass graft surgery in patients with ischaemic heart dysfunction. Br J Anaesth 86:169–175

    Article  CAS  PubMed  Google Scholar 

  165. Wagner F, Yeter R, Bisson S, Siniawski H, Hetzer R (2003) Beneficial hemodynamic and renal effects of intravenous enalaprilat following coronary artery bypass surgery complicated by left ventricular dysfunction. Crit Care Med 31:1421–1428

    Article  CAS  PubMed  Google Scholar 

  166. Fioretto P, Bruseghin M, Berto I, Gallina P, Manzato E, Mussap M (2006) Renal protection in diabetes: role of glycemic control. J Am Soc Nephrol 17:S86–S89

    Article  PubMed  Google Scholar 

  167. Ding H, Kopple JD, Cohen A, Hirschberg R (1993) Recombinant human insulin-like growth factor-I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure. J Clin Invest 91:2281–2287

    Article  CAS  PubMed  Google Scholar 

  168. Miller SB, Martin DR, Kissane J, Hammerman MR (1992) Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat. Proc Natl Acad Sci USA 89:11876–11880

    Article  CAS  PubMed  Google Scholar 

  169. Yasuda H, Kato A, Miyaji T, Zhou H, Togawa A, Hishida A (2004) Insulin-like growth factor-I increases p21 expression and attenuates cisplatin-induced acute renal injury in rats. Clin Exp Nephrol 8:27–35

    Article  CAS  PubMed  Google Scholar 

  170. Michael UF, Logan JL, Meeks LA (1991) The beneficial effects of thyroxine on nephrotoxic acute renal failure in the rat. J Am Soc Nephrol 1:1236–1240

    CAS  PubMed  Google Scholar 

  171. Sutter PM, Thulin G, Stromski M, Ardito T, Gaudio KM, Kashgarian M, Siegel NJ (1988) Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediatr Nephrol 2:1–7

    Article  CAS  PubMed  Google Scholar 

  172. Chatterjee PK (2005) Pleiotropic renal actions of erythropoietin. Lancet 365:1890–1892

    Article  CAS  PubMed  Google Scholar 

  173. Coleman T, Brines M (2004) Science review: recombinant human erythropoietin in critical illness: a role beyond anemia? Crit Care 8:337–341

    Article  PubMed  Google Scholar 

  174. Bernhardt WM, Eckardt KU (2008) Physiological basis for the use of erythropoietin in critically ill patients at risk for acute kidney injury. Curr Opin Crit Care 14:621–626

    Article  PubMed  Google Scholar 

  175. Bahlmann FH, Fliser D (2009) Erythropoietin and renoprotection. Curr Opin Nephrol Hypertens 18:15–20

    Article  CAS  PubMed  Google Scholar 

  176. Jungers P, Choukroun G, Oualim Z, Robino C, Nguyen AT, Man NK (2001) Beneficial influence of recombinant human erythropoietin therapy on the rate of progression of chronic renal failure in predialysis patients. Nephrol Dial Transplant 16:307–312

    Article  CAS  PubMed  Google Scholar 

  177. Maiese K, Chong ZZ, Shang YC (2008) Raves and risks for erythropoietin. Cytokine Growth Factor Rev 19:145–155

    Article  CAS  PubMed  Google Scholar 

  178. Yokomaku Y, Sugimoto T, Kume S, Araki S, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Nitta N, Haneda M, Koya D, Uzu T, Kashiwagi A (2008) Asialoerythropoietin prevents contrast-induced nephropathy. J Am Soc Nephrol 19:321–328

    Article  CAS  PubMed  Google Scholar 

  179. Mizutani A, Okajima K, Uchiba M, Noguchi T (2000) Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95:3781–3787

    CAS  PubMed  Google Scholar 

  180. Gupta A, Berg DT, Gerlitz B, Sharma GR, Syed S, Richardson MA, Sandusky G, Heuer JG, Galbreath EJ, Grinnell BW (2007) Role of protein C in renal dysfunction after polymicrobial sepsis. J Am Soc Nephrol 18:860–867

    Article  CAS  PubMed  Google Scholar 

  181. Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW (2007) Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2. Am J Physiol Renal Physiol 293:F245–F254

    Article  CAS  PubMed  Google Scholar 

  182. Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW (2009) Distinct functions of activated protein C differentially attenuate acute kidney injury. J Am Soc Nephrol 20:267–277

    Article  CAS  PubMed  Google Scholar 

  183. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in the critically ill patients. N Engl J Med 345:1359–1367

    Article  PubMed  Google Scholar 

  184. van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van WE, Bobbaers H, Bouillon R (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354:449–461

    Article  PubMed  Google Scholar 

  185. Schetz M, Vanhorebeek I, Wouters PJ, Wilmer A, van den BG (2008) Tight blood glucose control is renoprotective in critically ill patients. J Am Soc Nephrol 19:571–578

  186. Krinsley JS (2004) Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 79:992–1000

    Article  PubMed  Google Scholar 

  187. Lecomte P, Van VB, Coddens J, Cammu G, Nollet G, Nobels F, Vanermen H, Foubert L (2008) Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients. Crit Care 12:R154

    Article  PubMed  Google Scholar 

  188. Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D (2009) Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 180:821–827

    PubMed  Google Scholar 

  189. Arabi YM, Dabbagh OC, Tamim HM, Al-Shimemeri AA, Memish ZA, Haddad SH, Syed SJ, Giridhar HR, Rishu AH, Al-Daker MO, Kahoul SH, Britts RJ, Sakkijha MH (2008) Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit Care Med 36:3190–3197

    Article  CAS  PubMed  Google Scholar 

  190. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hebert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ (2009) Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360:1283–1297

    Article  PubMed  Google Scholar 

  191. Wiener RS, Wiener DC, Larson RJ (2008) Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 300:933–944

    Article  CAS  PubMed  Google Scholar 

  192. van den Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D (2009) Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target? J Clin Endocrinol Metab 94:3163–3170

    Article  PubMed  CAS  Google Scholar 

  193. Hirschberg R, Kopple J, Lipsett P, Benjamin E, Minei J, Albertson T, Munger M, Metzler M, Zaloga G, Murray M, Lowry S, Conger J, McKeown W, O’shea M, Baughman R, Wood K, Haupt M, Kaiser R, Simms H, Warnock D, Summer W, Hintz R, Myers B, Haenftling K, Capra W (1999) Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int 55:2423–2432

    Article  CAS  PubMed  Google Scholar 

  194. Franklin SC, Moulton M, Sicard GA, Hammerman MR, Miller SB (1997) Insulin-like growth factor I preserves renal function postoperatively. Am J Physiol 272:F257–F259

    CAS  PubMed  Google Scholar 

  195. Acker CG, Singh AR, Flick RP, Bernardini J, Greenberg A, Johnson JP (2000) A trial of thyroxine in acute renal failure. Kidney Int 57:293–298

    Article  CAS  PubMed  Google Scholar 

  196. Loef BG, Henning RH, Epema AH, Rietman GW, van OW, Navis GJ, Ebels T (2004) Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass. Br J Anaesth 93:793–798

  197. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699–709

    Article  CAS  PubMed  Google Scholar 

  198. Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, Johnson G III, Bernard GR (2003) Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 31:834–840

    Article  CAS  PubMed  Google Scholar 

  199. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, Corwin MJ, Colton T (2002) Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA 288:2827–2835

    Article  CAS  PubMed  Google Scholar 

  200. Pons M, Plante I, LeBrun M, Gourde P, Simard M, Grenier L, Thibault L, Labrecque G, Beauchamp D (2003) Protein-rich diet attenuates cyclosporin A-induced renal tubular damage in rats. J Ren Nutr 13:84–92

    Article  PubMed  Google Scholar 

  201. Roberts PR, Black KW, Zaloga GP (1997) Enteral feeding improves outcome and protects against glycerol-induced acute renal failure in the rat. Am J Respir Crit Care Med 156:1265–1269

    CAS  PubMed  Google Scholar 

  202. Zager RA (1987) Amino acid hyperalimentation in acute renal failure: a potential therapeutic paradox. Kidney Int Suppl 22:S72–S75

    CAS  PubMed  Google Scholar 

  203. Evans RG, Fitzgerald SM (2005) Nitric oxide and superoxide in the renal medulla: a delicate balancing act. Curr Opin Nephrol Hypertens 14:9–15

    Article  CAS  PubMed  Google Scholar 

  204. Haque MZ, Majid DS (2004) Assessment of renal functional phenotype in mice lacking gp91PHOX subunit of NAD(P)H oxidase. Hypertension 43:335–340

    Article  CAS  PubMed  Google Scholar 

  205. Haugen E, Nath KA (1999) The involvement of oxidative stress in the progression of renal injury. Blood Purif 17:58–65

    Article  CAS  PubMed  Google Scholar 

  206. Vaziri ND (2004) Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension. Curr Opin Nephrol Hypertens 13:93–99

    Article  CAS  PubMed  Google Scholar 

  207. Abel RM, Beck CH Jr, Abbott WM, Ryan JA Jr, Barnett GO, Fischer JE (1973) Improved survival from acute renal failure after treatment with intravenous essential L-amino acids and glucose. Results of a prospective, double-blind study. N Engl J Med 288:695–699

    Article  CAS  PubMed  Google Scholar 

  208. Badalamenti S, Gines P, Arroyo V, Llach J, Piera C, Rimola A, Jimenez W, Gaya J, Casamitjana R, Rivera F (1990) Effects of intravenous amino acid infusion and dietary proteins on kidney function in cirrhosis. Hepatology 11:379–386

    Article  CAS  PubMed  Google Scholar 

  209. Mouser JF, Hak EB, Kuhl DA, Dickerson RN, Gaber LW, Hak LJ (1997) Recovery from ischemic acute renal failure is improved with enteral compared with parenteral nutrition. Crit Care Med 25:1748–1754

    Article  CAS  PubMed  Google Scholar 

  210. Heyman SN, Goldfarb M, Shina A, Karmeli F, Rosen S (2003) N-Acetylcysteine ameliorates renal microcirculation: studies in rats. Kidney Int 63:634–641

    Article  CAS  PubMed  Google Scholar 

  211. Borgstrom L, Kagedal B, Paulsen O (1986) Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 31:217–222

    Article  CAS  PubMed  Google Scholar 

  212. Olsson B, Johansson M, Gabrielsson J, Bolme P (1988) Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34:77–82

    Article  CAS  PubMed  Google Scholar 

  213. Tepel M, van der GM, Schwarzfeld C, Laufer U, Liermann D, Zidek W (2000) Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343:180–184

  214. Baker CS, Wragg A, Kumar S, De PR, Baker LR, Knight CJ (2003) A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. J Am Coll Cardiol 41:2114–2118

    Article  PubMed  Google Scholar 

  215. Briguori C, Manganelli F, Scarpato P, Elia PP, Golia B, Riviezzo G, Lepore S, Librera M, Villari B, Colombo A, Ricciardelli B (2002) Acetylcysteine and contrast agent-associated nephrotoxicity. J Am Coll Cardiol 40:298–303

    Article  CAS  PubMed  Google Scholar 

  216. Durham JD, Caputo C, Dokko J, Zaharakis T, Pahlavan M, Keltz J, Dutka P, Marzo K, Maesaka JK, Fishbane S (2002) A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int 62:2202–2207

    Article  CAS  PubMed  Google Scholar 

  217. Kay J, Chow WH, Chan TM, Lo SK, Kwok OH, Yip A, Fan K, Lee CH, Lam WF (2003) Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. JAMA 289:553–558

    Article  CAS  PubMed  Google Scholar 

  218. MacNeill BD, Harding SA, Bazari H, Patton KK, Colon-Hernadez P, DeJoseph D, Jang IK (2003) Prophylaxis of contrast-induced nephropathy in patients undergoing coronary angiography. Catheter Cardiovasc Interv 60:458–461

    Article  PubMed  Google Scholar 

  219. Miner SE, Dzavik V, Nguyen-Ho P, Richardson R, Mitchell J, Atchison D, Seidelin P, Daly P, Ross J, McLaughlin PR, Ing D, Lewycky P, Barolet A, Schwartz L (2004) N-acetylcysteine reduces contrast-associated nephropathy but not clinical events during long-term follow-up. Am Heart J 148:690–695

    Article  CAS  PubMed  Google Scholar 

  220. Oldemeyer JB, Biddle WP, Wurdeman RL, Mooss AN, Cichowski E, Hilleman DE (2003) Acetylcysteine in the prevention of contrast-induced nephropathy after coronary angiography. Am Heart J 146:E23

    Article  PubMed  CAS  Google Scholar 

  221. Shyu KG, Cheng JJ, Kuan P (2002) Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol 40:1383–1388

    Article  CAS  PubMed  Google Scholar 

  222. Vallero A, Cesano G, Pozzato M, Garbo R, Minelli M, Quarello F, Formica M (2002) Contrast nephropathy in cardiac procedures: no advantages with prophylactic use of N-acetylcysteine (NAC). G Ital Nefrol 19:529–533

    CAS  PubMed  Google Scholar 

  223. Gonzales DA, Norsworthy KJ, Kern SJ, Banks S, Sieving PC, Star RA, Natanson C, Danner RL (2007) A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med 5:32

    Article  PubMed  CAS  Google Scholar 

  224. Gawenda M, Moller A, Wassmer G, Brunkwall J (2007) Prophylaxis of contrast-induced nephropathy with N-acetylcysteine. Zentralbl Chir 132:227–231

    Article  CAS  PubMed  Google Scholar 

  225. Zagler A, Azadpour M, Mercado C, Hennekens CH (2006) N-acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials. Am Heart J 151:140–145

    Article  CAS  PubMed  Google Scholar 

  226. Duong MH, MacKenzie TA, Malenka DJ (2005) N-acetylcysteine prophylaxis significantly reduces the risk of radiocontrast-induced nephropathy: comprehensive meta-analysis. Catheter Cardiovasc Interv 64:471–479

    Article  PubMed  Google Scholar 

  227. Pannu N, Manns B, Lee H, Tonelli M (2004) Systematic review of the impact of N-acetylcysteine on contrast nephropathy. Kidney Int 65:1366–1374

    Article  CAS  PubMed  Google Scholar 

  228. Alonso A, Lau J, Jaber BL, Weintraub A, Sarnak MJ (2004) Prevention of radiocontrast nephropathy with N-acetylcysteine in patients with chronic kidney disease: a meta-analysis of randomized, controlled trials. Am J Kidney Dis 43:1–9

    Article  CAS  PubMed  Google Scholar 

  229. Hoffmann U, Fischereder M, Kruger B, Drobnik W, Kramer BK (2004) The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. J Am Soc Nephrol 15:407–410

    Article  CAS  PubMed  Google Scholar 

  230. Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C (2000) N-Acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 28:3799–3807

    Article  CAS  PubMed  Google Scholar 

  231. Poletti PA, Saudan P, Platon A, Mermillod B, Sautter AM, Vermeulen B, Sarasin FP, Becker CD, Martin PY (2007) I.v. N-acetylcysteine and emergency CT: use of serum creatinine and cystatin C as markers of radiocontrast nephrotoxicity. AJR Am J Roentgenol 189:687–692

    Article  PubMed  Google Scholar 

  232. Chen SL, Zhang J, Yei F, Zhu Z, Liu Z, Lin S, Chu J, Yan J, Zhang R, Kwan TW (2008) Clinical outcomes of contrast-induced nephropathy in patients undergoing percutaneous coronary intervention: a prospective, multicenter, randomized study to analyze the effect of hydration and acetylcysteine. Int J Cardiol 126:407–413

    Article  PubMed  Google Scholar 

  233. Rashid ST, Salman M, Myint F, Baker DM, Agarwal S, Sweny P, Hamilton G (2004) Prevention of contrast-induced nephropathy in vascular patients undergoing angiography: a randomized controlled trial of intravenous N-acetylcysteine. J Vasc Surg 40:1136–1141

    Article  PubMed  Google Scholar 

  234. Lawlor DK, Moist L, DeRose G, Harris KA, Lovell MB, Kribs SW, Elliot J, Forbes TL (2007) Prevention of contrast-induced nephropathy in vascular surgery patients. Ann Vasc Surg 21:593–597

    Article  PubMed  Google Scholar 

  235. Coyle LC, Rodriguez A, Jeschke RE, Simon-Lee A, Abbott KC, Taylor AJ (2006) Acetylcysteine In Diabetes (AID): a randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics. Am Heart J 151:12–1032

    Article  CAS  Google Scholar 

  236. Heng AE, Cellarier E, Aublet-Cuvelier B, Decalf V, Motreff P, Marcaggi X, Deteix P, Souweine B (2008) Is treatment with N-acetylcysteine to prevent contrast-induced nephropathy when using bicarbonate hydration out of date? Clin Nephrol 70:475–484

    CAS  PubMed  Google Scholar 

  237. Staniloae CS, Doucet S, Sharma SK, Katholi RE, Mody KR, Coppola JT, Solomon R (2009) N-Acetylcysteine added to volume expansion with sodium bicarbonate does not further prevent contrast-induced nephropathy: results from the cardiac angiography in renally impaired patients study. J Interv Cardiol 22:261–265

    Article  PubMed  Google Scholar 

  238. Fung JW, Szeto CC, Chan WW, Kum LC, Chan AK, Wong JT, Wu EB, Yip GW, Chan JY, Yu CM, Woo KS, Sanderson JE (2004) Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: a randomized trial. Am J Kidney Dis 43:801–808

    Article  CAS  PubMed  Google Scholar 

  239. Gomes VO, Poli de Figueredo CE, Caramori P, Lasevitch R, Bodanese LC, Araujo A, Roedel AP, Caramori AP, Brito FS Jr, Bezerra HG, Nery P, Brizolara A (2005) N-Acetylcysteine does not prevent contrast induced nephropathy after cardiac catheterisation with an ionic low osmolality contrast medium: a multicentre clinical trial. Heart 91:774–778

    Article  CAS  PubMed  Google Scholar 

  240. Ristikankare A, Kuitunen T, Kuitunen A, Uotila L, Vento A, Suojaranta-Ylinen R, Salmenpera M, Poyhia R (2006) Lack of renoprotective effect of i.v. N-acetylcysteine in patients with chronic renal failure undergoing cardiac surgery. Br J Anaesth 97:611–616

    Article  CAS  PubMed  Google Scholar 

  241. Burns KE, Chu MW, Novick RJ, Fox SA, Gallo K, Martin CM, Stitt LW, Heidenheim AP, Myers ML, Moist L (2005) Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk patients undergoing CABG surgery: a randomized controlled trial. JAMA 294:342–350

    Article  CAS  PubMed  Google Scholar 

  242. Macedo E, Abdulkader R, Castro I, Sobrinho AC, Yu L, Vieira JM Jr (2006) Lack of protection of N-acetylcysteine (NAC) in acute renal failure related to elective aortic aneurysm repair-a randomized controlled trial. Nephrol Dial Transplant 21:1863–1869

    Article  CAS  PubMed  Google Scholar 

  243. Komisarof JA, Gilkey GM, Peters DM, Koudelka CW, Meyer MM, Smith SM (2007) N-Acetylcysteine for patients with prolonged hypotension as prophylaxis for acute renal failure (NEPHRON). Crit Care Med 35:435–441

    Article  CAS  PubMed  Google Scholar 

  244. Sisillo E, Ceriani R, Bortone F, Juliano G, Salvi L, Veglia F, Fiorentini C, Marenzi G (2008) N-Acetylcysteine for prevention of acute renal failure in patients with chronic renal insufficiency undergoing cardiac surgery: a prospective, randomized, clinical trial. Crit Care Med 36:81–86

    Article  CAS  PubMed  Google Scholar 

  245. Adabag AS, Ishani A, Koneswaran S, Johnson DJ, Kelly RF, Ward HB, McFalls EO, Bloomfield HE, Chandrashekhar Y (2008) Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trial. Am Heart J 155:1143–1149

    Article  CAS  PubMed  Google Scholar 

  246. Wijeysundera DN, Beattie WS, Rao V, Granton JT, Chan CT (2007) N-Acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency. Can J Anaesth 54:872–881

    Article  PubMed  Google Scholar 

  247. Sandilands EA, Bateman DN (2009) Adverse reactions associated with acetylcysteine. Clin Toxicol (Phila) 47:81–88

    CAS  Google Scholar 

  248. Molnar Z, Shearer E, Lowe D (1999) N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study. Crit Care Med 27:1100–1104

    Article  CAS  PubMed  Google Scholar 

  249. Peake SL, Moran JL, Leppard PI (1996) N-Acetyl-l-cysteine depresses cardiac performance in patients with septic shock. Crit Care Med 24:1302–1310

    Article  CAS  PubMed  Google Scholar 

  250. Spargias K, Alexopoulos E, Kyrzopoulos S, Iokovis P, Greenwood DC, Manginas A, Voudris V, Pavlides G, Buller CE, Kremastinos D, Cokkinos DV (2004) Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. Circulation 110:2837–2842

    Article  CAS  PubMed  Google Scholar 

  251. Boscheri A, Weinbrenner C, Botzek B, Reynen K, Kuhlisch E, Strasser RH (2007) Failure of ascorbic acid to prevent contrast-media induced nephropathy in patients with renal dysfunction. Clin Nephrol 68:279–286

    CAS  PubMed  Google Scholar 

  252. Wijnen MH, Vader HL, Van Den Wall Bake AW, Roumen RM (2002) Can renal dysfunction after infra-renal aortic aneurysm repair be modified by multi-antioxidant supplementation? J Cardiovasc Surg (Torino) 43:483–488

    CAS  Google Scholar 

  253. Angstwurm MW, Schottdorf J, Schopohl J, Gaertner R (1999) Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Crit Care Med 27:1807–1813

    Article  CAS  PubMed  Google Scholar 

  254. Angstwurm MW, Engelmann L, Zimmermann T, Lehmann C, Spes CH, Abel P, Strauss R, Meier-Hellmann A, Insel R, Radke J, Schuttler J, Gartner R (2007) Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 35:118–126

    Article  CAS  PubMed  Google Scholar 

  255. Reade MC, Fink MP (2005) Bench-to-bedside review: amelioration of acute renal impairment using ethyl pyruvate. Crit Care 9:556–560

    Article  PubMed  Google Scholar 

  256. Mishra V, Baines M, Perry SE, McLaughlin PJ, Carson J, Wenstone R, Shenkin A (2007) Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clin Nutr 26:41–50

    Article  CAS  PubMed  Google Scholar 

  257. Schindler R, Stahl C, Venz S, Ludat K, Krause W, Frei U (2001) Removal of contrast media by different extracorporeal treatments. Nephrol Dial Transplant 16:1471–1474

    Article  CAS  PubMed  Google Scholar 

  258. Lee PT, Chou KJ, Liu CP, Mar GY, Chen CL, Hsu CY, Fang HC, Chung HM (2007) Renal protection for coronary angiography in advanced renal failure patients by prophylactic hemodialysis. A randomized controlled trial. J Am Coll Cardiol 50:1015–1020

    Article  PubMed  Google Scholar 

  259. Frank H, Werner D, Lorusso V, Klinghammer L, Daniel WG, Kunzendorf U, Ludwig J (2003) Simultaneous hemodialysis during coronary angiography fails to prevent radiocontrast-induced nephropathy in chronic renal failure. Clin Nephrol 60:176–182

    CAS  PubMed  Google Scholar 

  260. Gabutti L, Marone C, Monti M, Malfanti M, Zwahlen U, Pasotti E, Colucci G, Schonholzer C (2003) Does continuous venovenous hemodiafiltration concomitant with radiological procedures provide a significant and safe removal of the iodinated contrast ioversol? Blood Purif 21:152–157

    Article  CAS  PubMed  Google Scholar 

  261. Huber W, Jeschke B, Kreymann B, Hennig M, Page M, Salmhofer H, Eckel F, Schmidt U, Umgelter A, Schweigart U, Classen M (2002) Haemodialysis for the prevention of contrast-induced nephropathy: outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review. Invest Radiol 37:471–481

    Article  CAS  PubMed  Google Scholar 

  262. Marenzi G, Marana I, Lauri G, Assanelli E, Grazi M, Campodonico J, Trabattoni D, Fabbiocchi F, Montorsi P, Bartorelli AL (2003) The prevention of radiocontrast-agent-induced nephropathy by hemofiltration. N Engl J Med 349:1333–1340

    Article  CAS  PubMed  Google Scholar 

  263. Marenzi G, Lauri G, Campodonico J, Marana I, Assanelli E, De MM, Grazi M, Veglia F, Fabbiocchi F, Montorsi P, Bartorelli AL (2006) Comparison of two hemofiltration protocols for prevention of contrast-induced nephropathy in high-risk patients. Am J Med 119:155–162

    Article  PubMed  Google Scholar 

  264. Reinecke H, Fobker M, Wellmann J, Becke B, Fleiter J, Heitmeyer C, Breithardt G, Hense HW, Schaefer RM (2007) A randomized controlled trial comparing hydration therapy to additional hemodialysis or N-acetylcysteine for the prevention of contrast medium-induced nephropathy: the Dialysis-versus-Diuresis (DVD) Trial. Clin Res Cardiol 96:130–139

    Article  CAS  PubMed  Google Scholar 

  265. Cruz DN, Perazella MA, Bellomo R, Corradi V, de CM, Kuang D, Ocampo C, Nalesso F, Ronco C (2006) Extracorporeal blood purification therapies for prevention of radiocontrast-induced nephropathy: a systematic review. Am J Kidney Dis 48:361–371

    Google Scholar 

  266. Naka T, Jones D, Baldwin I, Fealy N, Bates S, Goehl H, Morgera S, Neumayer HH, Bellomo R (2005) Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report. Crit Care 9:R90–R95

    Article  PubMed  Google Scholar 

  267. Amyot SL, Leblanc M, Thibeault Y, Geadah D, Cardinal J (1999) Myoglobin clearance and removal during continuous venovenous hemofiltration. Intensive Care Med 25:1169–1172

    Article  CAS  PubMed  Google Scholar 

  268. Schenk MR, Beck DH, Nolte M, Kox WJ (2001) Continuous veno-venous hemofiltration for the immediate management of massive rhabdomyolysis after fulminant malignant hyperthermia in a bodybuilder. Anesthesiology 94:1139–1141

    Article  CAS  PubMed  Google Scholar 

  269. Shigemoto T, Rinka H, Matsuo Y, Kaji A, Tsukioka K, Ukai T, Shimaoka H (1997) Blood purification for crush syndrome. Ren Fail 19:711–719

    Article  CAS  PubMed  Google Scholar 

  270. Heney D, Essex-Cater A, Brocklebank JT, Bailey CC, Lewis IJ (1990) Continuous arteriovenous haemofiltration in the treatment of tumour lysis syndrome. Pediatr Nephrol 4:245–247

    Article  CAS  PubMed  Google Scholar 

  271. Meier M, Nitschke M, Perras B, Steinhoff J (2005) Ethylene glycol intoxication and xylitol infusion—metabolic steps of oxalate-induced acute renal failure. Clin Nephrol 63:225–228

    CAS  PubMed  Google Scholar 

  272. Moreau CL, Kerns W, Tomaszewski CA, McMartin KE, Rose SR, Ford MD, Brent J (1998) Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group. J Toxicol Clin Toxicol 36:659–666

    Article  CAS  PubMed  Google Scholar 

  273. Saccente SL, Kohaut EC, Berkow RL (1995) Prevention of tumor lysis syndrome using continuous veno-venous hemofiltration. Pediatr Nephrol 9:569–573

    Article  CAS  PubMed  Google Scholar 

  274. Bolcal C, Akay HT, Bingol H, Doganci S, Yildirim V, Yenicesu M, Demirkilic U, Tatar H (2007) Leukodepletion improves renal function in patients with renal dysfunction undergoing on-pump coronary bypass surgery: a prospective randomized study. Thorac Cardiovasc Surg 55:89–93

    Article  CAS  PubMed  Google Scholar 

  275. Tang AT, Alexiou C, Hsu J, Sheppard SV, Haw MP, Ohri SK (2002) Leukodepletion reduces renal injury in coronary revascularization: a prospective randomized study. Ann Thorac Surg 74:372–377

    Article  PubMed  Google Scholar 

  276. Treacher DF, Sabbato M, Brown KA, Gant V (2001) The effects of leucodepletion in patients who develop the systemic inflammatory response syndrome following cardiopulmonary bypass. Perfusion 16(Suppl):67–73

    Article  PubMed  Google Scholar 

  277. Salamonsen RF, Anderson J, Anderson M, Bailey M, Magrin G, Rosenfeldt F (2005) Total leukocyte control for elective coronary bypass surgery does not improve short-term outcome. Ann Thorac Surg 79:2032–2038

    Article  PubMed  Google Scholar 

  278. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medical Intensive Care Unit, Department of Internal Medicine I, Medical University Innsbruck, Anichstasse, 31, 6020, Innsbruck, Austria

    Michael Joannidis

  2. Department of Internal Medicine III, University Hospital Vienna, Vienna, Austria

    Wilfred Druml

  3. Western Sussex Hospitals Trust, Brighton and Sussex Medical School, University of Sussex , Brighton, UK

    Lui G. Forni

  4. Department of Intensive Care, VU Medical Center, Amsterdam, The Netherlands

    A. B. Johan Groeneveld

  5. Department of Intensive Care, Burn Center, Queen Astrid Military Hospital, Neder-Over-Heembeek (Brussels), Belgium

    Patrick Honore

  6. Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

    Heleen M. Oudemans-van Straaten

  7. Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi 37, Vicenza, Italy

    Claudio Ronco

  8. Department of Intensive Care Medicine, University Hospital, Catholic University Leuven, Leuven, Belgium

    Marie R. C. Schetz

  9. Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Arend Jan Woittiez

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This article is discussed in the editorial available at: doi:10.1007/s00134-009-1683-1.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00134-010-1780-1

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Joannidis, M., Druml, W., Forni, L.G. et al. Prevention of acute kidney injury and protection of renal function in the intensive care unit. Intensive Care Med 36, 392–411 (2010). https://doi.org/10.1007/s00134-009-1678-y

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