In the article by Dellinger et al., published in the January 2008 issue of Intensive Care Medicine, the addition of two tables, labeled Scheme 1 and Scheme 2, and subsequent text changes should appear as follows.

On page 19, the first sentence in the Methods section should read as follows.

Sepsis is defined as infection plus systemic manifestations of infection (Scheme 1) (12).

On page 19, the first full sentence in the second column should read as follows.

An example of typical thresholds for identification of severe sepsis is shown in Scheme 2 (12, 13).

Scheme 1 and Scheme 2, which were not included in the article, appear as follows.

Scheme 1 Diagnostic criteria for sepsis. WBC, white blood cell; SBP, systolic blood pressure; MAP, mean arterial blood pressure; INR, international normalized ration; a PTT, activated partial thromboplastin time

Scheme 2

Severe Sepsis = Sepsis-Induced Tissue Hypoperfusion or Organ Dysfunction (any of the following thought to be due to the infection)

  • Sepsis induced hypotension

  • Lactate > upper limits lab normal

  • Urine output < 0.5 ml/kg hr for > 2 hrs despite adequate fluid resuscitation

  • ALI with PaO2/FIO2 < 250 in the absence of pneumonia as infection source

  • ALI with PaO2/FIO2 < 200 in the presence of pneumonia as infection source

  • Creatinine > 2.0 mg/dl (176.8 micromol/L)

  • Bilirubin > 2 mg/dl (34.2 micromol/L)

  • Platelet count < 100,000

  • Coagulopathy (INR > 1.5)

Adapted from Levy, MM, Fink MP, Marshall JC, et al: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Medicine 2003; 29:530–538. ACCP/SCCM Consensus Conference Committee: American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864–874

On page 21, the sentence in the second full paragraph should read as follows.

The committee assessed whether the desirable effects of adherence will outweigh the undesirable effects, and the strength of a recommendation reflects the group's degree of confidence in that assessment (Table 2).

The following errors appeared in Table 5.

  1. 1.

    Under Blood product administration recommendations:

    Fresh frozen plasma recommendation circle should be open

    Antithrombin recommendation circle should be closed

    Platelet recommendation circle should be open

  2. 2.

    Under Glucose control:

    Aim to keep blood glucose recommendation < 150 mg/dL (8.3 mmol/L) should have an open circle

On page 17 the Indian Society of Critical Care Medicine and the World Federation of Critical Care Nurses should be added to the list of sponsoring organizations who did not participate formally in the revision process.

The authors regret the errors.