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Postoperative phrenic nerve palsy: early clinical implications and management

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Abstract

Objective

We examined the clinical impact of diaphragmatic palsy (DP) as a result of phrenic nerve injury following cardiothoracic surgery, specifically its effects on morbidity and mortality, early regeneration capacity of the phrenic nerve, and role of surgical diaphragmatic plication.

Methods

A retrospective case control study was performed in 74 children with DP and 74 matched controls after cardiothoracic surgery within the past 14 years.

Results

Following 5,128 surgical procedures in children (aged under 18 years) we found an incidence of DP of 1.4%. There were no differences in mortality between the groups, and the cause of death was not related to DP or plication in any of the patients. However, patients with diaphragm impairment had significantly longer duration of mechanical ventilation (median 3 days vs. 1), ICU stay (7 days vs. 3.5), duration of hospital stay (16 days vs. 12), and for antibiotic treatment (16 days vs. 7). Because of prolonged respiratory problems 40 children (54%) underwent surgical diaphragmatic plication to flatten the diaphragm in its inspiratory position. In children with DP younger age was a strong predictor for plication (median 3.8 months vs. 12.1).

Conclusions

Especially in newborns and young infants with DP the length of mechanical ventilation, ICU stay, and hospital stay are prolonged. Early spontaneous recovery of the phrenic nerve is rare. In cases of respiratory impairment early transthoracic diaphragmatic plication is an effective means of treatment.

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Acknowledgements

We thank Anne M. Gale, ELS, for editorial assistance.

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Authors and Affiliations

  1. Department of Congenital Heart Disease, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Julia Lemmer, Brigitte Stiller, Grit Heise, Valerie Amann, Stanislav Ovroutski & Felix Berger

  2. Department of Thoracic and Cardiovascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Michael Hübler, Vladimir Alexi-Meskishvili & Yuguo Weng

  3. Department of Anesthesiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Matthias Redlin

Authors
  1. Julia Lemmer
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  2. Brigitte Stiller
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  3. Grit Heise
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  4. Michael Hübler
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  5. Vladimir Alexi-Meskishvili
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  8. Valerie Amann
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  9. Stanislav Ovroutski
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  10. Felix Berger
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Corresponding author

Correspondence to Julia Lemmer.

Additional information

This article is discussed in the editorial available at: http://dx.doi.org/10.1007/s00134-006-0209-3

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Lemmer, J., Stiller, B., Heise, G. et al. Postoperative phrenic nerve palsy: early clinical implications and management. Intensive Care Med 32, 1227–1233 (2006). https://doi.org/10.1007/s00134-006-0208-4

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  • DOI: https://doi.org/10.1007/s00134-006-0208-4

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