Skip to main content
SpringerLink
Log in

Sedation and analgesia in the PICU: many questions remain

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Playfor S, Jenkins I, Boyles C, Choonara I, Davies G, Haywood T, Hinson G, Mayer H, Morton NS, Ralph T, Wolf A (2006) Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med DOI 10.1007/s00134-0190-x

  2. Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ (2003) Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Med 29:980–984

    PubMed  Google Scholar 

  3. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology: drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167

    Article  PubMed  CAS  Google Scholar 

  4. van Dijk M, Bouwmeester J, Koot HM, Boer de JB, Passchier J, Tibboel D (2002) Efficacy of continuous versus intermittent morphine administration after major surgery in 0 to 3-year old infants: a double-blind randomised controlled trial. Pain 98:298–306

    Article  Google Scholar 

  5. Prins SA, Peeters MYM, Houmes RJ, van Dijk M, Knibbe CAJ, Danhof M, Tibboel D (2005) Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery. Br J Anaesth 94:630–635

    Article  PubMed  CAS  Google Scholar 

  6. Symington A, Pinelli J (2003) Developmental care for promoting development and preventing morbidity in preterm infants. Cochrane Database Syst Rev CD001814

  7. Arenas-Lopez S, Riphagen S, Tibby SM, Durward A, Tomlin S, Davies G, Murdoch IA (2004) Use of oral clonidine for sedation in ventilated paediatric intensive care patients. Intensive Care Med 30:1625–1629

    Article  PubMed  Google Scholar 

  8. Courtman SP, Wardurgh A, Petros AJ (2003) Comparison of the bispectral index monitor with the Comfort score in assessing level of sedation of critically ill children. Intensive Care Med 29:2239–2246

    Article  PubMed  Google Scholar 

  9. Benini F, Trapanotto M, Sartori S, Capretta A, Gobber D, Boniver C, Zacchello F (2005) Analysis of the bispectral index during natural sleep in children. Anesth Analg 101:641–644

    Article  PubMed  Google Scholar 

  10. Anand KJ, Arnold JH (1994) Opioid tolerance and dependence in infants and children. Crit Care Med 22:334–342

    Article  PubMed  CAS  Google Scholar 

  11. Ducharme C, Carnevale FA, Clermont M-S, Shea S (2005) A prospective study of adverse reactions to the weaning of opioids and benzodiazepines among critically ill children. Intensive Crit Care Nursing 21:179–186

    Google Scholar 

  12. Bray RJ (1998) Propofol infusion syndrome in children. Paediatr Anaesth 8:491–499

    Article  PubMed  CAS  Google Scholar 

  13. Olney JW, Young C, Wozniak DF, Ikonomidou C, Jevtovic-Todorovic V (2004) Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? Anesthesiology 101:273–275

    Article  PubMed  CAS  Google Scholar 

  14. Young C, Jevtovic-Todorovic V, Qin YQ, Tenkova T, Wang H, Labruyere J, Olney JW (2005) Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol 4:4

    Google Scholar 

  15. Evans WE, Relling MV (2004) Moving towards individualized medicine with pharmacogenomics. Nature 429:464–468

    Article  PubMed  CAS  Google Scholar 

  16. Wilson JT (1999) An update on the therapeutic orphan. Pediatrics 104:585–590

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, Erasmus MC – Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands

    Sandra Prins, Monique van Dijk & Dick Tibboel

Authors
  1. Sandra Prins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Monique van Dijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dick Tibboel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dick Tibboel.

Additional information

This editorial refers to the article available at: http://dx.doi.org/10.1007/s00134-006-0190-x

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prins, S., van Dijk, M. & Tibboel, D. Sedation and analgesia in the PICU: many questions remain. Intensive Care Med 32, 1103–1105 (2006). https://doi.org/10.1007/s00134-006-0191-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-006-0191-9

Search

Navigation