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Septic shock: a heart story since the 1960s

  • Seminal Study in Intensive Care
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References

  1. MacLean LD, Mulligan WG, McLean AP, Duff JH (1967) Patterns of septic shock in man-a detailed study of 56 patients. Ann Surg 166:543–562

    Article  PubMed  CAS  Google Scholar 

  2. Waisbren BA (1951) Bacteremia due to gram-negative bacilli other than the Salmonella; a clinical and therapeutic study. Arch Intern Med 88:467–488

    CAS  Google Scholar 

  3. Clowes GH Jr, Vucinic M, Weidner MG (1966) Circulatory and metabolic alterations associated with survival or death in peritonitis: clinical analysis of 25 cases. Ann Surg 163:866–885

    Article  PubMed  Google Scholar 

  4. Weil MH, MacLean LD, Visscher MB (1956) Studies on the circulatory changes in the dog produced by endotoxin from Gram-negative microorganisms. J Clin Invest 35:1191–1198

    Article  PubMed  CAS  Google Scholar 

  5. Postel J, Schloerb PR (1977) Cardiac depression in bacteremia. Ann Surg 186:74–82

    Article  PubMed  CAS  Google Scholar 

  6. Packman MI, Rackow EC (1983) Optimum left heart filling pressure during fluid resuscitation of patients with hypovolemic and septic shock. Crit Care Med 11:165–169

    Article  PubMed  CAS  Google Scholar 

  7. Wilson RF, Thal AP, Kindling PH, Grifka T, Ackerman E (1965) Hemodynamic measurements in septic shock. Ann Surg 91:121–129

    Google Scholar 

  8. Weisel RD, Vito L, Dennis RC, Valeri CR, Hechtman HB (1977) Myocardial depression during sepsis. Am J Surg 133:512–521

    Article  PubMed  CAS  Google Scholar 

  9. Winslow EJ, Loeb HS, Rahimtoola SH, Kamath S, Gunnar RM (1973) Hemodynamic studies and results of therapy in 50 patients with bacteremic shock. Am J Med 54:421–432

    Article  PubMed  CAS  Google Scholar 

  10. Krausz MM, Perel A, Eimerl D, Cotev S (1977) Cardiopulmonary effects of volume loading in patients in septic shock. Ann Surg 185:429–434

    Article  PubMed  CAS  Google Scholar 

  11. Parker MM, Shelhamer JH, Natanson C, Alling DW, Parrillo JE (1987) Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit Care Med 15:923–929

    Article  PubMed  CAS  Google Scholar 

  12. Ahmed AJ, Kruse JA, Haupt MT, Chandrasekar PH, Carlson RW (1991) Hemodynamic responses to gram-positive versus gram-negative sepsis in critically ill patients with and without circulatory shock. Crit Care Med 19:1520–1525

    Article  PubMed  CAS  Google Scholar 

  13. Carroll GC, Snyder JV (1982) Hyperdynamic severe intravascular sepsis depends on fluid administration in cynomolgus monkey. Am J Physiol 243:R131–R141

    PubMed  CAS  Google Scholar 

  14. Teule GJ, den Hollander W, Bronsveld W, Koopman PA, Bezemer PD, Heidendal GA, Thijs LG (1983) Effect of volume loading and dopamine on hemodynamics and red-cell redistribution in canine endotoxin shock. Circ Shock 10:41–50

    PubMed  CAS  Google Scholar 

  15. Natanson C, Fink MP, Ballantyne HK, MacVittie TJ, Conklin JJ, Parrillo JE (1986) Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 78:259–270

    Article  PubMed  CAS  Google Scholar 

  16. Natanson C, Danner RL, Fink MP, MacVittie TJ, Walker RI, Conklin JJ, Parrillo JE (1988) Cardiovascular performance with E. coli challenges in a canine model of human sepsis. Am J Physiol 254:H558–H569

    PubMed  CAS  Google Scholar 

  17. Abi-Gerges N, Tavernier B, Mebazaa A, Faivre V, Paqueron X, Payen D, Fischmeister R, Mery PF (1999) Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat. Am J Respir Crit Care Med 160:1196–1204

    PubMed  CAS  Google Scholar 

  18. Faivre V, Kaskos H, Callebert J, Losser MR, Milliez P, Bonnin P, Payen D, Mebazaa A (2005) Cardiac and renal effects of levosimendan, arginine vasopressin and norepinephrine in endotoxin-treated rabbits. Anesthesiology 103:514–521

    Article  PubMed  CAS  Google Scholar 

  19. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM, Damske BA, Parrillo JE (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483–490

    PubMed  CAS  Google Scholar 

  20. Ellrodt AG, Riedinger MS, Kimchi A, Berman DS, Maddahi J, Swan HJ, Murata GH (1985) Left ventricular performance in septic shock: reversible segmental and global abnormalities. Am Heart J 110:402–409

    Article  PubMed  CAS  Google Scholar 

  21. Natanson C, Danner RL, Elin RJ, Hosseini JM, Peart KW, Banks SM, MacVittie TJ, Walker RI, Parrillo JE (1989) Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock. J Clin Invest 83:243–251

    Article  PubMed  CAS  Google Scholar 

  22. Natanson C, Eichenholz PW, Danner RL, Eichacker PQ, Hoffman WD, Kuo GC, Banks SM, MacVittie TJ, Parrillo JE (1989) Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 169:823–832

    Article  PubMed  CAS  Google Scholar 

  23. Monsalve F, Rucabado L, Salvador A, Bonastre J, Cunat J, Ruano M (1984) Myocardial depression in septic shock caused by meningococcal infection. Crit Care Med 12:1021–1023

    Article  PubMed  CAS  Google Scholar 

  24. Jafri SM, Lavine S, Field BE, Bahorozian MT, Carlson RW (1990) Left ventricular diastolic function in sepsis. Crit Care Med 18:709–714

    Article  PubMed  CAS  Google Scholar 

  25. Poelaert J, Declerck C, Vogelaers D, Colardyn F, Visser CA (1997) Left ventricular systolic and diastolic function in septic shock. Intensive Care Med 23:553–560

    Article  PubMed  CAS  Google Scholar 

  26. Ognibene FP, Parker MM, Natanson C, Shelhamer JH, Parrillo JE (1988) Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock. Chest 93:903–910

    Article  PubMed  CAS  Google Scholar 

  27. Mebazaa A, Karpati P, Renaud E, Algotsson L (2004) Acute right ventricular failure-from pathophysiology to new treatments. Intensive Care Med 30:185–196

    Article  PubMed  Google Scholar 

  28. Parker MM, McCarthy KE, Ognibene FP, Parrillo JE (1990) Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans. Chest 97:126–131

    Article  PubMed  CAS  Google Scholar 

  29. Cunnion RE, Schaer GL, Parker MM, Natanson C, Parrillo JE (1986) The coronary circulation in human septic shock. Circulation 73:637–644

    PubMed  CAS  Google Scholar 

  30. Dhainaut JF, Huyghebaert MF, Monsallier JF, Lefevre G, Dall'Ava-Santucci J, Brunet F, Villemant D, Carli A, Raichvarg D (1987) Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 75:533–541

    PubMed  CAS  Google Scholar 

  31. Lanone S, Mebazaa A, Heymes C, Henin D, Poderoso JJ, Panis Y, Zedda C, Billiar T, Payen D, Aubier M, Boczkowski J (2000) Muscular contractile failure in septic patients: role of the inducible nitric oxide synthase pathway. Am J Respir Crit Care Med 162:2308–2315

    PubMed  CAS  Google Scholar 

  32. Wu AH (2001) Increased troponin in patients with sepsis and septic shock: myocardial necrosis or reversible myocardial depression? Intensive Care Med 27:959–961

    Article  PubMed  CAS  Google Scholar 

  33. Wangensteen SL, Geissinger WT, Lovett WL, Glenn TM, Lefer AM (1971) Relationship between splanchnic blood flow and a myocardial depressant factor in endotoxin shock. Surgery 69:410–418

    PubMed  CAS  Google Scholar 

  34. Parrillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, Schuette W (1985) A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 76:1539–1553

    Article  PubMed  CAS  Google Scholar 

  35. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL (1992) Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257:387–389

    Article  PubMed  CAS  Google Scholar 

  36. Kumar A, Thota V, Dee L, Olson J, Uretz E, Parrillo JE (1996) Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med 183:949–958

    Article  PubMed  CAS  Google Scholar 

  37. Tavernier B, Mebazaa A, Mateo P, Sys S, Ventura-Clapier R, Veksler V (2001) Phosphorylation-dependent alteration in myofilament ca2+ sensitivity but normal mitochondrial function in septic heart. Am J Respir Crit Care Med 163:362–367

    PubMed  CAS  Google Scholar 

  38. Mebazaa A, De Keulenaer GW, Paqueron X, Andries LJ, Ratajczak P, Lanone S, Frelin C, Longrois D, Payen D, Brutsaert DL, Sys SU (2001) Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: role of endothelin, prostaglandins, and nitric oxide. Circulation 104:3137–3144

    Article  PubMed  CAS  Google Scholar 

  39. Tavernier B, Li JM, El-Omar MM, Lanone S, Yang ZK, Trayer IP, Mebazaa A, Shah AM (2001) Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J 15:294–296

    PubMed  CAS  Google Scholar 

  40. Ungureanu-Longrois D, Balligand J, Okada I, Simmons W, Kobzik L, Loweinstein C, Kunkel S, Michel T, Kelly R, Smith T (1995) Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res 77:486–493

    PubMed  CAS  Google Scholar 

  41. Reithmann C, Hallstrom S, Pilz G, Kapsner T, Schlag G, Werdan K (1993) Desensitization of rat cardiomyocyte adenylyl cyclase stimulation by plasma of noradrenaline-treated patients with septic shock. Circ Shock 41:48–59

    PubMed  CAS  Google Scholar 

  42. Silverman H, Penaranda R, Orens J, Lee N (1993) Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines. Crit Care Med 21:31–39

    Article  PubMed  CAS  Google Scholar 

  43. Lew WY, Yasuda S, Yuan T, Hammond HK (1996) Endotoxin-induced cardiac depression is associated with decreased cardiac dihydropyridine receptors in rabbits. J Mol Cell Cardiol 28:1367–1371

    Article  PubMed  CAS  Google Scholar 

  44. Tavernier B, Garrigue D, Boulle C, Vallet B, Adnet P (1998) Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits. Cardiovasc Res 38:472–479

    Article  PubMed  CAS  Google Scholar 

  45. Layland J, Cave AC, Warren C, Grieve DJ, Sparks E, Kentish JC, Solaro RJ, Shah AM (2005) Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J 19:1137–1139

    PubMed  CAS  Google Scholar 

  46. Shah A (1998) Paracrine modulation of heart cell function by endothelial cells. Cardiovasc Res 31:847–867

    Article  Google Scholar 

  47. Morelli A, De Castro S, Teboul JL, Singer M, Rocco M, Conti G, De Luca L, Di Angelantonio E, Orecchioni A, Pandian NG, Pietropaoli P (2005) Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 31:638–644

    Article  PubMed  Google Scholar 

  48. Grover R, Zaccardelli D, Colice G, Guntupalli K, Watson D, Vincent JL (1999) An open-label dose escalation study of the nitric oxide synthase inhibitor, N (G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med 27:913–922

    Article  PubMed  CAS  Google Scholar 

  49. Ishida H, Ichimori K, Hirota Y, Fukahori M, Nakazawa H (1996) Peroxynitrite-induced cardiac myocyte injury. Free Radic Biol Med 20:343–350

    Article  PubMed  CAS  Google Scholar 

  50. Xie YW, Kaminski PM, Wolin MS (1998) Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation. Circ Res 82:891–897

    PubMed  CAS  Google Scholar 

  51. Lancel S, Tissier S, Mordon S, Marechal X, Depontieu F, Scherpereel A, Chopin C, Neviere R (2004) Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats. J Am Coll Cardiol 43:2348–2358

    Article  PubMed  CAS  Google Scholar 

  52. Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M (2002) Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 360:219–223

    Article  PubMed  CAS  Google Scholar 

  53. Neviere R, Fauvel H, Chopin C, Formstecher P, Marchetti P (2001) Caspase inhibition prevents cardiac dysfunction and heart apoptosis in a rat model of sepsis. Am J Respir Crit Care Med 163:218–225

    PubMed  CAS  Google Scholar 

  54. Fauvel H, Marchetti P, Chopin C, Formstecher P, Neviere R (2001) Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosis. Am J Physiol Heart Circ Physiol 280:H1608–H1614

    PubMed  CAS  Google Scholar 

  55. Lancel S, Joulin O, Favory R, Goossens JF, Kluza J, Chopin C, Formstecher P, Marchetti P, Neviere R (2005) Ventricular myocyte caspases are directly responsible for endotoxin-induced cardiac dysfunction. Circulation 111:2596–2604

    Article  PubMed  CAS  Google Scholar 

  56. Fauvel H, Marchetti P, Obert G, Joulain O, Chopin C, Formstecher P, Neviere R (2002) Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. Am J Respir Crit Care Med 165:449–455

    PubMed  Google Scholar 

  57. Lancel S, Petillot P, Favory R, Stebach N, Lahorte C, Danze PM, Vallet B, Marchetti P, Neviere R (2005) Expression of apoptosis regulatory factors during myocardial dysfunction in endotoxemic rats. Crit Care Med 33:492–496

    Article  PubMed  CAS  Google Scholar 

  58. Gattinoni L, Brazzi L, Pelosi P, Latini R, Tognoni G, Pesenti A, Fumagalli R (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 333:1025–1032

    Article  PubMed  CAS  Google Scholar 

  59. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, the Early Goal-Directed Therapy Collaborative Group (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377

    Article  PubMed  CAS  Google Scholar 

  60. Decking UK, Flesche CW, Godecke A, Schrader J (1995) Endotoxin-induced contractile dysfunction in guinea pig hearts is not mediated by nitric oxide. Am J Physiol 268:H2460–H2465

    PubMed  CAS  Google Scholar 

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Rabuel, C., Mebazaa, A. Septic shock: a heart story since the 1960s. Intensive Care Med 32, 799–807 (2006). https://doi.org/10.1007/s00134-006-0142-5

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