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Correlation between intra-abdominal and intracranial pressure in nontraumatic brain injury

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Abstract

Objective

To examine on the basis of a large number of measurements whether increased IAP is associated with increased ICP and decreased CPP in ventilated patients with nontraumatic brain injury.

Design and setting

Observational clinical study in the medical and surgical intensive care unit of a tertiary teaching hospital.

Patients

We included 11 patients with nontraumatic brain injury who had an ICP and an IAP-monitoring device because of ischemic (n=4), hemorrhagic (n=5), and metabolic (n=2) encephalopathy.

Methods

IAP was continuously measured in the stomach, and ICP was continuously measured through an intraventricular catheter; 214 consecutive measurements were compared. Because of repeated measurements in the patients we used analysis of covariance to control for the variation in ICP and CPP between patients.

Measurements and results

Patients’ mean IAP was 3.8–11.8 mmHg, ICP 6.7–15 mmHg, and CPP 70.8–123 mmHg. For ICP the regression coefficient associated with IAP was 0.64±0.05 (95% CI 0.56–0.73, partial correlation 0.70) and for CPP −1.36±0.3 (95% CI −1.94 to −0.78; partial correlation −0.30).

Conclusions

Increases in IAP are associated with increases in ICP and decreases in CPP in ventilated patients with nontraumatic brain injury, even at low levels of IAP.

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Authors and Affiliations

  1. Department of Internal Medicine, ZiekenhuisNetwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, 2060, Antwerp, Belgium

    Dries H. Deeren

  2. Intensive Care Unit, ZiekenhuisNetwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, 2060, Antwerp, Belgium

    Hilde Dits & Manu L. N. G. Malbrain

Authors
  1. Dries H. Deeren
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  2. Hilde Dits
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  3. Manu L. N. G. Malbrain
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Corresponding author

Correspondence to Manu L. N. G. Malbrain.

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This study was not supported by industry or other sources

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Deeren, D.H., Dits, H. & Malbrain, M.L.N.G. Correlation between intra-abdominal and intracranial pressure in nontraumatic brain injury. Intensive Care Med 31, 1577–1581 (2005). https://doi.org/10.1007/s00134-005-2802-2

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  • DOI: https://doi.org/10.1007/s00134-005-2802-2

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