Skip to main content
Log in

Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome?

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Skillman JJ, Bushnell LS, Goldman H, Silen W (1969) Respiratory failure, hypotension, sepsis, and jaundice. A clinical syndrome associated with lethal hemorrhage and acute stress ulceration in the stomach. Am J Surg 117:523–530

    Google Scholar 

  2. Baue AE (1975) Multiple, progressive, or sequential systems failure. A syndrome of the 1970s. Arch Surg 110:779–781

    CAS  PubMed  Google Scholar 

  3. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RMH, Sibbald WJ (1992) ACCP/SCCM consensus conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644–1655

    CAS  PubMed  Google Scholar 

  4. Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A, for the ARDS Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308

    Article  PubMed  Google Scholar 

  5. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E, the Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group (1999) A multicentre randomized controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340:409–417

    Article  CAS  PubMed  Google Scholar 

  6. Marshall JC (2001) Inflammation, coagulopathy, and the pathogenesis of the multiple organ dysfunction syndrome. Crit Care Med 29 [Suppl]:S106

  7. Marzocco S, Di Paola R, Mazzon E, Genovese T, Britti D, Pinto A, Autore G, Cuzzocrea S (2005) The cyclopentone prostaglandin 15-deoxyΔ12:14 PGJ2 attenuates the development of zymosan-induced shock. Intensive Care Med (http://dx.doi.org/10.1007/s00134-005-2596-2)

  8. Volman TJH, Goris RJA, Hendriks T (2005) Pentoxifylline does not improve outcome in a murine model for the multiple organ dysfunction syndrome. Intensive Care Med (http://dx.doi.org/10.1007/s00134-005-2570-z)

  9. Steinberg S, Flynn W, Kelly K, Bitzer L, Sharma P, Gutierrez C, Baxter J, Lalka D, Sands A, Van Liew J, Hassett J, Price R, Beam T, Flint L (1989) Development of a bacteria independent model of the multple organ failure syndrome. Arch Surg 124:1390–1395

    Google Scholar 

  10. Schwieterman W, Roberts R (1997) FDA perspective on study design for therapies for severe sepsis. Sepsis 1:69

    Google Scholar 

  11. Piper RD, Cook DJ, Bone RC, Sibbald WJ (1996) Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 24:2059–2070

    Google Scholar 

  12. Villa P, Sartor G, Angelini M, Sironi M, Conni M, Gnocchi P, Isetta AM, Grau G, Buurman W, van Tits LJ, (1995) Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin. Clin Diagn Lab Immunol 2:549–553

    Google Scholar 

  13. Yang S, Zhou M, Koo DJ, Chaudry IH, Wang P (1999) Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsis. Am J Physiol 277:H1036–H1044

    Google Scholar 

  14. Staubach KH, Schröder J, Stüber F, Gehrke K, Traumann E, Zabel P (1998) Effect of pentoxifylline in severe sepsis. Results of a randomized, double-blind, placebo-controlled study. Arch Surg 133:94–100

    Google Scholar 

  15. Shukla VK, Ojha AK, Pandey M, Pandey BL (2001) Pentoxifylline in perforated peritonitis: results of a randomised, placebo controlled trial. Eur J Surg 167:622–624

    Google Scholar 

  16. Marshall JC (2003) Such stuff as dreams are made on: mediator-targeted therapy in sepsis. Nat Rev Drug Disc 2:391–405

    Google Scholar 

  17. Marshall JC, Creery D (1998) Pre-clinical models of sepsis. Sepsis 2:187–197

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John C. Marshall.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marshall, J.C. Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome?. Intensive Care Med 31, 605–608 (2005). https://doi.org/10.1007/s00134-005-2595-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-005-2595-3

Navigation