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An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study

Intensive Care Medicine volume 32, pages 421–427 (2006)Cite this article

Abstract

Objective

To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs

Design and setting

Cohort, multicentre, observational study of 198 ICUs in 24 European countries.

Patients and interventions

All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.

Results

During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.

Conclusions

Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.

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Acknowledgements

This research was endorsed by the European Society for Intensive Care Medicine, and supported by an unlimited grant from Abbott, Baxter, Eli Lilly, GlaxoSmithKline and NovoNordisk.

Author information

Authors and Affiliations

  1. Department of Anaesthesiology and Critical Care Medicine, Hadassah Hebrew University, Medical Center, P.O. Box 1200, 91120, Jerusalem, Israel

    Charles L. Sprung

  2. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium

    Yasser Sakr & Jean-Louis Vincent

  3. Department of Intensive Care, Saint-Louis Hospital, Paris, France

    Jean-Roger Le Gall

  4. Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Jena, Jena, Germany

    Konrad Reinhart

  5. Department of Anaesthesiology and Intensive Care, University of Turin, S. Giovanni Battista Hospital, Turin, Italy

    V. Marco Ranieri

  6. Department of Anaesthesiology and Intensive Care, Vivantes-Klinikum Neuköln, Berlin, Germany

    Herwig Gerlach

  7. Department of Intensive Care, Royal Berkshire Hospital, Reading, UK

    Jonathan Fielden

  8. Department of Anaesthesiology and Intensive Care, University Hospital Lewisham, London, UK

    C. B. Groba

  9. Department of Anaesthesiology and Intensive Care, Centre Hospitalier Universitaire Lariboisiere, Paris, France

    Didier Payen

Authors
  1. Charles L. Sprung
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  2. Yasser Sakr
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  3. Jean-Louis Vincent
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  4. Jean-Roger Le Gall
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  5. Konrad Reinhart
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  6. V. Marco Ranieri
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  7. Herwig Gerlach
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  8. Jonathan Fielden
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  9. C. B. Groba
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  10. Didier Payen
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Corresponding author

Correspondence to Charles L. Sprung.

Additional information

On behalf of the Sepsis Occurrence in Acutely Ill Patients investigators

Endorsed by the European Society for Intensive Care Medicine, and supported by an unlimited grant from Abbott, Baxter, Eli Lilly, GlaxoSmithKline and NovoNordisk

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Sprung, C.L., Sakr, Y., Vincent, JL. et al. An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study. Intensive Care Med 32, 421–427 (2006). https://doi.org/10.1007/s00134-005-0039-8

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  • DOI: https://doi.org/10.1007/s00134-005-0039-8

Keywords

  • Infections
  • Systemic inflammatory response syndrome
  • Sepsis
  • Severe sepsis
  • Septic shock
  • Prognosis