Abstract
Objective
To describe a nosocomial outbreak of gastric mucormycosis caused by Rhizopus microsporus var. rhizopodiformis in five adult patients admitted to an intensive care unit (ICU).
Design
Epidemiological surveillance study.
Setting
A 12-bed polyvalent ICU of an acute care teaching hospital in Pamplona, Spain.
Patients
Five patients admitted to the ICU requiring artificial ventilation, diagnosis on admission severe pneumonia in four patients and one polytrauma patient, within a 14-week period, were diagnosed with gastric mucormycosis based on microbiological and/or histopathological characteristics. Upper gastrointestinal bleeding was the presenting manifestation in 80% of patients.
Interventions
Filamentous fungi isolated at the microbiology laboratory of the hospital were examined at the national Mycology Reference Laboratory in Madrid.
Measurements and results
Rhizopus microsporus var. rhizopodiformis growth was detected in gastric aspiration samples, environmental samples, wooden tongue depressors used to prepare oral medications (and given to patients through a nasogastric catheter), and in some tongue depressors stored in unopened boxes unexposed to the ICU environment. All depressors were purchased from the same supplier. R. microsporus was not isolated from batches purchased at different times from the same supplier and from another supplier. The outbreak terminated when contaminated tongue depressors were withdrawn from use.
Conclusions
Wooden tongue depressors contaminated by R. microsporus var. rhizopodiformis used to prepare oral medications caused an outbreak of fungal gastritis with an attributable mortality of 40%. Wooden material should not be used in the hospital setting.
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References
Parfrey NA (1986) Improved diagnosis and prognosis of mucormycosis: a clinicopathologic study of 33 cases. Medicine (Baltimore) 65:113–123
Khan LB (1963) Gastric mucormycosis: report of a case with a review of the literature. S Afr Med J 37:1265–1269
Corley DA, Lindeman N, Ostroff JW (1997) Survival with early diagnosis of invasive gastric mucormycosis in a heart transplant patient. Gastrointest Endosc 46:452–454
Thomson SR, Bade PG, Taams M, Chrystal V (1991) Gastrointestinal mucormycosis. Br J Surg 78:952–954
Lawson H, Schmaman A (1974) Gastric phycomycosis. Br J Surg 61:743–746
Ribes JA, Vanover-Sams CL, Baker DJ (2000) Zygomycetes in human disease. Clin Microbiol Rev 13:236–301
García de Jalón J, Maraví-Poma E, Repáraz Abaitua F, Jiménez Urra I, Espatolero Esparza MJ, Gutiérrez Oliver A, Panizo Delgado A (1996) Incidencia de infecciones nosocomiales en una unidad de cuidados intensivos polivalente. Asociación a los factores de riesgo. Med Intensiva 20:6–14
Baker RD (1957) Mucormycosis, a new disease? J Am Med Assoc 163:806–808
Burchard KW (1992) Fungal Sepsis. Infect Dis Clin North Am 7:677–692
Neame P, Rayner D (1960) Mucormycosis: a report on 22 cases. Arch Pathol 70:261–268
Verweij PE, Voss A, Donnelly JP, De Pauw B, Meis JFGM (1997) Wooden sticks as the source of a pseudoepidemic of infection with Rhizopus microsporus var. rhizopodiformis among immunocompromised patients. J Clin Microbiol 35:2422–2423
Leeming JG, Moss HA, Elliot TSJ (1996). Risk of tongue depressors to the immunocompromised. Lancet 348:889
Harper JJ, Coulter C, Lye GR, Nimmo GR (1996) Rhizopus and tongue depressors. Lancet 348:1250
Holzel H, Macqeen S, MacDonald A, Alexander S, Campbell CK, Johnson EM, Warnock DW (1998) Rhizopus microsporus in wooden tongue depressors: a major threat or minor inconvenience? J Hosp Infection 38:113–118
Mitchell SJ, Gray J, Morgan MEI, Hocking MD, Durbin GM (1996) Nosocomial infection with Rhizopus microsporus in preterm infants; association with wooden tongue depressors. Lancet 348:441–443
Acknowledgements
We thank Gilead Sciencies, S.L., for financial support in logistic aspects of the study, J. Mestre, B. Sesma, and J. Rello for critical review of the manuscript, R. Kimball for translation into English, and M. Pulido for editing the manuscript and for editorial assistance.
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This work was presented in part at the 11th Annual Congress of the European Society of Intensive Care Medicine (ESICM), Stockholm, Sweden, 1998.
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Maraví-Poma, E., Rodríguez-Tudela, J.L., de Jalón, J.G. et al. Outbreak of gastric mucormycosis associated with the use of wooden tongue depressors in critically ill patients. Intensive Care Med 30, 724–728 (2004). https://doi.org/10.1007/s00134-003-2132-1
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DOI: https://doi.org/10.1007/s00134-003-2132-1