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Intensive Care Medicine

, Volume 30, Issue 1, pp 18–32 | Cite as

Dosing of medications in morbidly obese patients in the intensive care unit setting

  • Brian L. ErstadEmail author
Review

Abstract

Objective

To derive recommendations for the dosing of commonly used medications in the morbidly obese patient in the ICU.

Data sources

Articles were obtained through computerized searches involving MEDLINE. The bibliographies of retrieved publications and textbooks were reviewed for additional references.

Study selection

All studies involving the pharmacokinetics or pharmacodynamics of medications in obese subjects or patients.

Data extraction

The emphasis was on studies involving morbidly obese patients but, in the absence of such data, investigations involving lesser forms of obesity were extracted.

Data synthesis

There is a paucity of data upon which to make recommendations for dosing commonly used medications in the morbidly obese patient in the ICU, although recommendations were provided based on the available information.

Conclusions

There is clearly a need for more investigations involving dosing regimens of medications in the morbidly obese population. Until such studies are available, the clinician must try to derive the best dosing regimens for medications based on the limited pharmacokinetic data available for some agents and clinical judgement.

Keywords

Morbid obesity Dosing Pharmacokinetics Intensive care 

Supplementary material

Table 1

Pharmacokinetic studies of medications in morbidly obese patients

table1.pdf (187 kb)
(PDF 187 KB)
Table 2

Summary of recommendations for dosing medications in morbidly obese patients in the ICU setting

table2.pdf (182 kb)
(PDF 182 KB)

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of Pharmacy Practice and ScienceCollege of PharmacyTucsonUSA

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