References
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, and Fisher Jr C for the PROWESS study group (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699–709
Esmon CT (2001) Protein C anticoagulation pathway and its role in controlling microvascular thrombosis and inflammation. Crit Care Med [Suppl 29]:S48–51
Esmon CT (2000) Regulation of blood coagulation. Biochim Biophys Acta 1477:349–360
Cardigan RA, McGloin H, Mackie IJ, Machin SJ, Singer M (1999) Activation of the tissue factor pathway occurs during continuous venovenous hemofiltration. Kidney Int 55:1568–1574
Gori AM, Pepe G, Attanasio M, Falciani M, Abbate R, Prisco D, Fedi S, Giusti B, Brunelli T, Comeglio P, Gensini GF, Neri Serneri GG (1999) Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration. Thromb Haemost 81:589–593
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
de Pont, A.C.J.M., Bouman, C.S.C., de Jonge, E. et al. Treatment with recombinant human activated protein C obviates additional anticoagulation during continuous venovenous hemofiltration in patients with severe sepsis. Intensive Care Med 29, 1205 (2003). https://doi.org/10.1007/s00134-003-1781-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00134-003-1781-4