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H2 Antagonist-induced thrombocytopenia: is this a real phenomenon?

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Abstract.

Critically ill patients routinely receive H2 antagonists for stress ulcer prophylaxis while at risk for gastrointestinal bleeding. In these patients it is often difficult to assess accurately the cause of adverse effects such as thrombocytopenia. We evaluate the literature to better define thrombocytopenia related to H2 antagonist administration and discuss mechanism, potential as a risk factor and case reports describing the severity and duration of thrombocytopenia.

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Authors and Affiliations

  1. Department of Pharmacy, University of Pittsburgh Medical Center, 304 Scaife Hall, 200 Lothrop Street, Pittsburgh, PA 15213, USA

    Emily E. Wade

  2. Department of Surgery, Division of Trauma/Critical Care, University of Vermont College of Medicine, Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, VT 05401, USA

    Jill A. Rebuck, Mark A. Healey & Frederick B. Rogers

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  1. Emily E. Wade
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  2. Jill A. Rebuck
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  3. Mark A. Healey
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  4. Frederick B. Rogers
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Wade, E.E., Rebuck, J.A., Healey, M.A. et al. H2 Antagonist-induced thrombocytopenia: is this a real phenomenon?. Intensive Care Med 28, 459–465 (2002). https://doi.org/10.1007/s00134-002-1233-6

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  • DOI: https://doi.org/10.1007/s00134-002-1233-6

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