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Wachstumsfaktoren und Signalmoleküle zur Anwendung im „Tissue Engineering“

Targeting und innovative Releasesysteme

Tissue engineering of cartilage and bone

Growth factors and signaling molecules

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Zusammenfassung

Moderne Tissue-Engineering-Strategien stützen sich auf die Kombination von Zellen, Scaffolds sowie Signalmolekülen und Wachstumsfaktoren. Für das „Tissue Engineering“ von Knorpel und Knochen stellt die Wachstumsfuge der langen Röhrenknochen eine interessante, gut organisierte Struktur mit Chondrozyten in unterschiedlichen Proliferations- und Differenzierungsstadien in einem Scaffold aus unterschiedlichen Komponenten der extrazellulären Matrix dar. Die Proliferation und Differenzierung dieser Chondrozyten wird durch eine große Zahl hormoneller und parakriner Faktoren reguliert. Der Beitrag diskutiert einige wichtige Wachstumsfaktoren der enchondralen Ossifikation und zeigt an einem Beispiel auf, wie, ausgehend vom „Targeting“ in der Wachstumsfuge, ein solches Molekül in ein Releasesystem für Tissue-Engineering-Strategien integriert werden kann.

Abstract

Modern tissue engineering concepts integrate cells, scaffolds, signaling molecules and growth factors. In tissue engineering of cartilage, the growth plate of the long bone represents an interesting, well-organized developmental structure, with a spatial distribution of chondrocytes in different proliferation and differentiation stages embedded in a scaffold of extracellular matrix components. The proliferation and differentiation of these chondrocytes is regulated by various hormonal and paracrine factors. This article discusses some important growth factors in the process of endochondral ossification and demonstrates how this information could be translated into a controlled release system for different tissue engineering strategies.

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Danksagung

Diese Arbeit wurde im Rahmen des Europäischen Exzellenznetzwerks für Tissue Engineering (EXPERTISSUES) durchgeführt und finanziell unterstützt durch die Firma NovoNordisk.

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Authors and Affiliations

  1. REPAIR-lab, Institut für Pathologie, Universitätsmedizin, Johannes Gutenberg-Universität, Langenbeckstraße 1, 55101, Mainz, Deutschland

    C. Brochhausen, M. Lehmann & C. J. Kirkpatrick

  2. Institut für Werkstoffwissenschaften und -technologien, Technische Universität, Berlin, Deutschland

    R. Zehbe

  3. Eicosanoid- & Massenspektrometrisches Labor, Zentrum für Kinder- und Jugendmedizin, Philipps-Universität, Marburg, Deutschland

    B. Watzer

  4. AO-Forschungsinstitut, Davos, Schweiz

    S. Grad

  5. Orthopädische Universitätsklinik Friedrichsheim gGmbH, Johann Wolfgang-Goethe-Universität, Frankfurt, Deutschland

    A. Meurer

Authors
  1. C. Brochhausen
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  2. M. Lehmann
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  3. R. Zehbe
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  4. B. Watzer
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  5. S. Grad
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  6. A. Meurer
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  7. C. J. Kirkpatrick
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Corresponding author

Correspondence to C. Brochhausen.

Additional information

Teile dieses Manuskriptes wurden bei den Michaelis Lectures am Trinity College in Cambridge (UK) am 26. Nov. 2008 präsentiert.

Dieser Beitrag enthält Material der medizinischen Doktorarbeit von Frau Meike Lehmann.

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Brochhausen, C., Lehmann, M., Zehbe, R. et al. Wachstumsfaktoren und Signalmoleküle zur Anwendung im „Tissue Engineering“. Orthopäde 38, 1053–1062 (2009). https://doi.org/10.1007/s00132-009-1496-5

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  • DOI: https://doi.org/10.1007/s00132-009-1496-5

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