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Tenozyten und extrazelluläre Matrix

Eine wechselseitige Beziehung

Tenocytes and the extracellular matrix

A reciprocal relationship

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Zusammenfassung

Tenozyten sind die charakteristischen Zellen der Sehnen und Bänder, welche für den Auf- und Umbau der extrazellulären Matrix verantwortlich sind. Sie reagieren auf äußere Reize und ermöglichen die funktionelle Anpassung des Proteoglykan- und Kollagengerüsts an die mechanische Beanspruchung. Sie bilden über zahlreiche Fortsätze ein komplexes miteinander kommunizierendes Netzwerk, welches gemeinsame gerichtete Reaktionen zeigt. Sehnen unterliegen wie alle Gewebe des menschlichen Körpers einer altersbedingten Veränderung, welche die Zellen, aber auch die strukturelle Organisation und damit die Funktion der extrazellulären Matrix beeinflusst. Funktion und Organisation der Sehnen werden darüber hinaus durch mechanische Beanspruchung, das Auftreten verschiedener Zytokine im Gewebe und die Gabe antiphlogistisch wirkender Pharmaka beeinflusst.

Abstract

The characteristic cells in tendons and ligaments are called tenocytes, which are responsible for the formation and turnover of the extracellular matrix. They react to external stimuli and facilitate the functional adaptation of the proteoglycan and collagen network to mechanical requirements. Via numerous cellular processes they form a complex communicating network which demonstrates coordinated directional reactions. As is common to all tissues in the human body, tendons are subject to age changes which influence the tenocytes, but additionally the structural organization and hence the function of the extracellular matrix. The function and organization of tendons are also affected by mechanical forces, as well as by various cytokines produced in the tissue and by the application of anti-inflammatory medication.

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  1. AO Research Institute, Davos, Schweiz

    S. Milz & B. Ockert

  2. Anatomische Anstalt, Ludwig-Maximilians-Universität, Pettenkoferstraße 11, 80336, München, Deutschland

    S. Milz & R. Putz

  3. Chirurgische Klinik und Poliklinik – Campus Innenstadt, Ludwig-Maximilians-Universität, München, Deutschland

    B. Ockert

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Milz, S., Ockert, B. & Putz, R. Tenozyten und extrazelluläre Matrix. Orthopäde 38, 1071–1079 (2009). https://doi.org/10.1007/s00132-009-1490-y

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