Zusammenfassung
Interkorporelle Metallimplantate haben im Rahmen von lumbalen Spondylodesen in den letzten 15 Jahren weltweite Verbreitung gefunden. Die sog. „Cages“ bestehen aus metallischen oder resorbierbaren Materialien und können mit Hilfe verschiedener Operationstechniken offen oder endoskopisch eingesetzt werden.
Die publizierten Ergebnisse der cagegestützten Operationsverfahren an der Lendenwirbelsäule zeigen sowohl mit als auch ohne zusätzliche Instrumentierung überwiegend hohe knöcherne Fusionsraten von >90%, wobei die zusätzliche Applikation osteoinduktiver Substanzen (v. a. BMP) noch zu einer weiteren Verbesserung zu führen scheint.
Da die dorsoventrale Spondylodese mit Fixateur interne und Knochen gleich hohe Konsolidierungsraten aufweist, sind die Vorzüge der Cages in erster Linie in der Aufrechterhaltung des Distraktionseffekts, in der Möglichkeit eines einseitigen Vorgehens ohne zusätzliche Instrumentation (auch endoskopisch) und in der geringeren „donor-side morbidity“ im Bereich der Knochenentnahmestelle zu sehen.
Abstract
Over the last 15 years, interbody metal implants have become commonly used worldwide for lumbar interbody fusion. The so called “cages” are made of metal or absorbable materials. By using different surgical techniques, they can be implanted either regularly or via endoscopy.
The published results on surgical techniques using cages for the lumbar spine show, in most cases and with or without additional instrumentation, rates of fusion of more than 90%. It seems that the use of osteoinductive substances (especially BMP) leads to even better results.
Dorsoventral fusion with internal fixation and bone show the same rate of consolidation, but the advantages of cages are primarily in the maintenance of the distraction and the possibility of a single surgical procedure without additional instrumentation (including endoscopy), and in a lower donor side morbidity.
Literatur
Agazzi S, Reverdin A, May D (1999) Posterior lumbar interbody fusion with cages: an independent review of 71 cases. J Neurosurg Spine 91 [2 Suppl]: 186–192
Bader RJ, Steinhauser E, Rechl H, Mittelmeier W, Bertagnoli R, Gradinger R (2002) Mechanical studies of lumbar interbody fusion implants. Orthopäde 31(5): 459–465
Bagby GW (1988) Arthrodesis by the distraction-compression method using a stainless steel implant. Orthopedics 11(6): 931–934
Boden SD (1998) Bone repair and enhancement clinical trial design. Spine applications. Clin Orthop Relat Res 355 [Suppl]: 336–346
Boden SD, Schimandle JH, Hutton WC et al. (1997) In vivo evaluation of a resorbable osteoinductive composite as a graft substitute for lumbar spinal fusion. J Spinal Desord 10(1): 1–11
Boden SD, Martin GJ Jr, Horton WC, Truss TL, Sandhu HS (1998) Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage. J Spinal Disord 11(2): 95–101
Boden SD, Titus L, Hair G et al. (1998) Lumbar spine fusion by local gene therapy with a cDNA endoding a novel osteoinductive protein (LMP-1). Spine 23: 2486–2492
Boden SD, Zdeblick TA, Sandhu HS, Heim SE (2000) The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine 25(3): 376–381
Brantigan JW, Neidre A, Toohey JS (2004) The Lumbar I/F Cage for posterior lumbar interbody fusion with the variable screw placement system: 10-year results of a Food and Drug Administration clinical trial. Spine J 4(6): 681–688
Brodsky AE, Kovalsky ES, Khalil MA (1991) Correlation of radiologic assessment of lumbar spine fusions with surgical exploration. Spine 16 [6 Suppl]: 261–265
Burkus JK (2002) Intervertebral fixation: clinical results with anterior cages. Orthop Clin North Am 32(2): 349–571
Burkus JK (2004) Bone morphogenetic proteins in anterior lumbar interbody fusion: old techniques and new technologies. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves. J Neurosurg Spine 1(3): 254–260
Burkus JK, Gornet MF, Dickman CA, Zdeblick TA (2002) Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15(5): 337–349
Chen L, Tang T, Yang H (2003) Complications associated with posterior lumbar interbody fusion using Bagby and Kuslich method for treatment of spondylolisthesis. Clin Med J (Engl) 116(1): 99–103
Chitnavis B, Barbagallo G, Selway R et al. (2001) Posterior lumbar interbody fusion for revision disc surgery: review of 50 cases in which carbon fiber cages were implanted. J Neurosurg Spine 95(2): 190–195
Christensen FB, Hansen ES, Eiskjaer SP et al. (2002) Circumferential lumbar spinal fusion with Brantigan cage versus posterolateral fusion with titanium Cotrel-Dubousset instrumentation: a prospective, randomized clinical study of 146 patients. Spine 27(23): 2674–2683
Commarmond J (2001) One-segment interbody lumbar arthrodesis using impacted cages: posterior unilateral approach versus posterior bilateral approach. Rev Chir Orthop Reparatrice Appar Mot 87(2): 129–134
Couture DE, Branch CL Jr (2004) Posterior lumbar interbody fusion with bioabsorbable spacers and local autograft in a series of 27 patients. Neurosurg Focus 16(3): E8
Cunningham BW, Polly DW Jr (2002) The use of interbody cage devices for spinal deformity: a biomechanical perspective. Clin Orthop Relat Res 394: 73–83
Cunningham BW, Kanayama M, Parker LM et al. (1999) Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine. A comparative endoscopic study using the Bagby and Kuslich interbody fusion device. Spine 24(6): 509–518
Diedrich O, Kraft CN, Bertram R, Wagner U, Schmitt O (2000) Dorsal lumbar interbody implantation of cages for stabilizing segmental spinal instabilities. Z Orthop Ihre Grenzgeb 138(2): 162–168
Dimar JR 2nd, Beck DJ, Glassman SD, Voor MJ, Wang M (2001) Posterior lumbar interbody cages do not augment segmental biomechanical stability. Am J Orthop 30(8): 636–639
Elias WJ, Simmons NE, Kaptain GJ, Chadduck JB, Whitehill R (2000) Complications of posterior lumbar interbody fusion when using a titanium threaded cage device. J Neurosurg Spine 93 [1 Suppl]: 45–52
Escobar E, Transfeldt E, Garvey T, Ogilvie J, Graber J, Schultz L (2003) Video-assisted versus open anterior lumbar spine fusion surgery: a comparison of four techniques and complications in 135 patients. Spine 28(7): 729–732
Eysel P, Furderer S, Rompe JD, Zollner J (2000) Initial instability of different cages for fusion of the cervical spine. Zentralbl Neurochir 61(4): 171–176
Fischgrund JS, Mackay M, Herkowitz HN, Brower R, Montgomery DM, Kurz LT (1997) 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine 22(24): 2807–2812
Früh HJ, Liebetrau A, Bertagnoli R (2002) Fusionsimplantate aus kohlenstofffaserverstärktem Kunststoff. Orthopäde 31(5): 454–458
Hecht BP, Fischgrund JS, Herkowitz HN, Penman L, Toth JM, Shirkhoda A (1999) The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model. Spine 24(7): 629–636
Hee HT, Castro FP Jr, Majd ME, Holt RT, Myers L (2001) Anterior/posterior lumbar fusion versus transforaminal lumbar interbody fusion: analysis of complications and predictive factors. J Spinal Disord 14(6): 533–540
Heim SE, Altimari A (2002) Laparoscopic approaches to fusion of the lumbosacral spine: latest techniques. Orthop Clin North Am 33(2): 413–420
Henssge EJ, Hannslik L (1979) Implantat als Ersatz für spongiös aufgebaute Knochen. DPA p 2910267
Holte DC, O’Brien JP, Renton P (1994) Anterior lumbar fuxion using a hybrid interbody graft. A preliminary radiographic report. Eur Spine J 3(1): 32–38
Janssen ME, Nguyen C, Beckham R, Larson A (2000) Biological cages. Eur Spine J 9 [Suppl 1]: 102–109
Janssen ME, Lam C, Beckham R (2001) Outcomes of allogenic cages in anterior and posterior lumbar interbody fusion. Eur Spine J 10 [Suppl 2]: 158–168
Kanayama M, Cunningham BW, Weis JC et al. (1998) The effects of rigid spinal instrumentation and solid bony fusion on spinal kinematics. A posterolateral spinal arthrodesis model. Spine 23(7): 767–773
Kanayama M, Cunningham BW, Haggerty CJ et al. (2000) In vitro biomechanical investigation of the stability and stress-shielding effect of lumbar interbody fusion devices. J Neurosurg Spine 93 [2 Suppl]: 259–265
Kandziora F, Pflugmacher R, Schafer J et al. (2001) Biomechanical comparison of cervical spine interbody fusion cages. Spine 26(17): 1850–1857
Katkhouda N, Campos GM, Mavor E et al. (1999) Is laparoscopic approach to lumbar spine fusion worthwhile? Am J Surg 178(6): 458–461
Kettler A, Dietl R, Krammer M et al. (2002) Dislokationstendenz, stabilisierende Wirkung und Einbruchtendenz unterschiedlicher LWS-Cages im in-vitro-Experiment. Orthopäde 31(5): 481–487
Khodadadyan-Klosterman C, Kandziora F, Schnake KJ, Lewandrowski KU, Wise D, Weiler A, Haas NP (2001) Mechanical comparison of biodegradable intervertebral lumbar cages. Chirug 72(12): 1431–1438
Krüger M, Henssge EJ, Sellin D (1985) Gegossene spongiös-metallische Implantate im Tierversuch. Z. Orthop Ihre Grenzgeb 123(6): 962–965
Kuslich SD, Ulstrom CL, Griffith SL et al. (1998) The Bagby and Kuslich method of lumbar interbody fusion. History, techniques, and 2-year follow-up results of a United States prospective, multicenter trial. Spine 23(11): 1267–1279
Kuslich SD, Danielson G, Dowdle JD et al. (2000) Four-year follow-up results of lumbar spine arthrodesis using the Bagby and Kuslich lumbar fusion cage. Spine 25(20): 2656–2662
Lieberman IH, Willsher PC, Litwin DE, Salo PT, Kraetschmer BG (2000) Transperitoneal laparoscopic exposure for lumbar interbody fusion. Spine 25(4): 509–514
Lowe TG, Tahernia AD, O’Brien MF, Smith DA (2002) Unilateral transforaminal posterior lumbar interbody fusion (TLIF): indications, technique, and 2-year results. J Spinal Disord Tech 15(1): 31–38
Lowe TG, Coe JD (2002) Bioresorbable polymer implants in the unilateral transforaminal lumbar interbody fusion procedure. Orthopedics 25 [10 Suppl]: 1179–1183
Maciejczak A, Radek A (1998) Lumbar interbody fusion. Biomechanical significance for the spine. Neurol Neurochir Pol 32(5): 1247–1259
Madan SS, Harley JM, Boeree NR (2003) Anterior lumbar interbody fusion: does stable anterior fixation matter? Eur Spine J 12(4): 386–392
Magin MN, Delling G (2001) Improved lumbar vertebral interbody fusion using rhOP-1 : a comparison of autogenous bone graft, bovine hydroxylapatite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 26(5): 469–478
Matge G, Leclercq TA (2000) Rationale for interbody fusion with threaded titanium cages at cervical and lumbar levels. Results on 357 cases. Acta Neurochir (Wien) 142(4): 425–433
McAfee PC (1999) Interbody fusion cages in reconstructive operations on the spine. J Bone Joint Surg Am 81(6): 859–880
McAfee PC, Lee GA, Fedder IL, Cunningham BW (2002) Anterior BAK instrumentation and fusion: complete versus partial discectomy. Clin Orthop Relat Res 394: 55–63
Meyer P (2000) Universal spine fracture classification. Chir Organi Mov 85(2): 95–100
Molinari RW, Bridwell KH, Lenke LG, Baldus C (2002) Anterior column support in surgery for high-grade, isthmic spondylolisthesis. Clin Orthop Relat Res 394: 109–120
Mulholland RC (2000) Cages: outcome and complications. Eur Spine J 9 [Suppl 1]: 110–113
Mummaneni PV, Pan J, Haid RW, Rodts GE (2004) Contribution of recombinant human bone morphogenetic protein-2 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosurg Spine 1(1): 19–23
Ohyama T, Kubo Y, Iwata H, Taki W (2004) β-tricalcium phosphate combined with recombinant human bone morphogenetic protein-2: a substitute for autograft, used for packing interbody fusion cages in the canine lumbar spine. Neurol Med Chir (Tokyo) 44(5): 234–241
Oxland TR, Lund T (2000) Biomechanics of stand-alone cages and cages in combination with posterior fixation: a literature review. Eur Spine J 9 [Suppl 1]: 95–101
Pellise F, Puig O, Rivas A, Bago J, Villanueva C (2002) Low fusion rate after L5-S1 laparoscopic anterior lumbar interbody fusion using twin stand-alone carbon fiber cages. Spine 27(15): 1665–1669
Pitzen T, Matthis D, Caspar W, Muller-Storz H, Steudel WI (2000) Initial stability of two PLIF-techniques. A biomechanical comparison using a finite element model. Orthopade 29(1): 68–72
Ray CD (1997) Threaded titanium cages for lumbar interbody fusions. Spine 22(6): 667–679
Regan JJ, Yuan H, McAfee PC (1999) Laparoscopic fusion of the lumbar spine: minimally invasive spine surgery. A prospective multicenter study evaluating open and laparoscopic lumbar fusion. Spine 24(4): 402–411
Rosenberg WS, Mummaneni PV (2001) Transforaminal lumbar interbody fusion: technique, complications, and early results. Neurosurgery 48(3): 569–575
Salehi SA, Tawk R, Ganju A, LaMarca F, Liu JC, Ondra SL (2004) Transforaminal lumbar interbody fusion: surgical technique and results in 24 patients. Neurosurgery 54(2): 368–374
Salis-Soglio G von (1982) Die ventrale interkorporelle Distraktions-Spondylodese an der Lendenwirbelsäule — eine tierexperimentelle Studie. Z Orthop (120): 509
Salis-Soglio G von (1985) Die ventrale interkorporelle Distraktions-Spondylodese an der Lendenwirbelsäule. Z Orthop 123: 852–858
Salis-Soglio G von (1992) Anterior lumbar fusion using a memory alloy implant. Orthopaedics Traumaology, pp 165–176
Sandhu HS (2000) Anterior lumbar interbody fusion with osteoinductive growth factors. Clin Orthop Relat Res 371: 56–60
Sasso RC, Kitchel SH, Dawson EG (2004) A prospective, randomized controlled clinical trial of anterior lumbar interbody fusion using a titanium cylindrical threaded fusion device. Spine 29(2): 113–122
Schiffman M, Brau SA, Henderson R, Gimmestad G (2003) Bilateral implantation of low-profile interbody fusion cages: subsidence, lordosis, and fusion analysis. Spine J 3(5): 377–387
Schneid S, Sabitzer RJ, Fuss FK, Grupp TM, Blömer W (2002) In-vitro-Stabilitätsuntersuchung eines neuartigen Implantatsystems für den minimal- invasiven transforaminalen Zugang. Orthopäde 31(5): 488–493
Shikinami Y, Okuno M (2003) Mechanical evaluation of novel spinal interbody fusion cages made of bioactive, resorbable composites. Biomaterials 24(18): 3161–3170
Stoltze D, Harms J (1999) Correction of posttraumatic deformities. Principles and methods. Orthopade 28(8): 731–745
Thalgott JS, Giuffre JM, Klezl Z, Timlin M (2002) Anterior lumbar interbody fusion with titanium mesh cages, coralline hydroxyapatite, and demineralized bone matrix as part of a circumferential fusion. Spine J 2(1): 63–69
Togawa D, Bauer TW, Brantigan JW, Lowery GL (2001) Bone graft incorporation in radiographically successful human intervertebral body fusion cages. Spine 26(24): 2744–2750
Toth JM, Seim HB 3rd, Schwardt JD et al. (2000) Direct current electrical stimulation increases the fusion rate of spinal fusion cages. Spine 25(20): 2580–2587
Tsantrizos A, Andreou A, Aebi M, Steffen T (2000) Biomechanical stability of five stand-alone anterior lumbar interbody fusion constructs. Eur Spine J 9(1): 14–22
Tsantrizos A, Baramki HG, Zeidman S, Steffen T (2000) Segmental stability and compressive strength of posterior lumbar interbody fusion implants. Spine 25(15): 1899–1907
Van Dijk M, Smit TH, Burger EH, Wuisman PI (2002) Bioabsorbable poly-L-lactic acid cages for lumbar interbody fusion: three-year follow-up radiographic, histologic, and histomorphometric analysis in goats. Spine 27(23): 2706–2714
Zdeblick TA (1993) A prospective, randomized study of lumbar fusion. Preliminary results. Spine 18(8): 983–991
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Freiherr von Salis-Soglio, G., Scholz, R. & Seller, K. Interkorporelle Metallimplantate („Cages“) bei lumbalen Spondylodesen. Orthopäde 34, 1033–1039 (2005). https://doi.org/10.1007/s00132-005-0840-7
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DOI: https://doi.org/10.1007/s00132-005-0840-7