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Medikamentöse Therapie des komplexen regionalen Schmerzsyndroms Typ I

Drug therapy in complex regional pain syndrome type I

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Zusammenfassung

Unterschiedliche medikamentöse Therapieansätze in der Behandlung des CRPS Typ I („complex regional pain syndrome type I“) werden in einer Übersicht dargestellt und hinsichtlich ihres Evidenzlevels bewertet. Als medikamentöse Behandlungsalternativen werden nichtsteroidale Antirheumatika (NSAR), Kortikosteroide, freie Radikalfänger, Antidepressiva, Antikonvulsiva, Lokalanästhetika, opiodartige Analgetika, Clonidin, Capsaicin, NMDA-Rezeptor-Antagonisten, Kalzitonin, Bisphosphonate, GABAB-Agonisten, α-Blocker, intravenöse Regionalanästhesie (IVRA; Bretylium/Ketanserin), IVRA (Clonidin), intravenöse regionale Sympathikusblockade (IVRSB), Grenzstrangblockade mit Lokalanästhetika, ganglionäre lokale Opiodanalgesie (GLOA) und das Prostazyklinanalogon Iloprost besprochen.

Abstract

Pharmacologic treatment options for complex regional pain syndrome (CRPS) type I are discussed and drug effectiveness is graded according to the level of evidence available. Various drug strategies in the treatment of CRPS type I, i.e. NSAIDs, corticosteroids, free radical scavengers, antidepressants, anticonvulsants, local anesthetics, opioid analgesics, clonidine, capsaicin, NMDA receptor antagonists, calcitonin, bisphosphonates, GABAB-agonists, α-blockers, IVRA (bretylium/ketanserin), IVRA (clonidine), IVRSB, local anesthetics sympathetic blockade, GLOA and iloprost are discussed.

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  1. Orthopädische Universitätsklinik Stiftung Friedrichsheim

    R. von Eisenhart-Rothe & M. Rittmeister

  2. Forschungsgruppe Kinematik und Biomechanik, Orthopädische Universitätsklinik Stiftung Friedrichsheim, Marienburgstraße 2, 60528, Frankfurt

    R. von Eisenhart-Rothe

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von Eisenhart-Rothe, R., Rittmeister, M. Medikamentöse Therapie des komplexen regionalen Schmerzsyndroms Typ I. Orthopäde 33, 796–803 (2004). https://doi.org/10.1007/s00132-004-0674-8

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