Zusammenfassung
Die perkutane Vertebroplastie wurde 1984 von Galibert et al. zur Therapie von Hämangiomen an der Wirbelsäule entwickelt. Die Indikation erweiterte sich in der Folge auf osteoporotische Kompressionsfrakturen, sowie osteolytische Herde unterschiedlicher Entität.
Mit der steigenden Anzahl an Anwendungen insbesondere durch die Fachdisziplinen Orthopädie, Traumatologie, Neurochirurgie und Radiologie kam es auch zu einer Zunahme an Komplikationen. In den vergangenen 3 Jahren findet sich in der Literatur eine stetig steigende Anzahl an Kasuistiken über unterschiedlichste Komplikationen, deren Entstehung, sowie das nachfolgende Therapiemanagement. Die Komplikationsliste reicht von harmlosen paravertebralen Zementaustritten und temporären kardiopulmonalen Ereignissen über Lungenembolien mit letalem Ausgang bis hin zu schwerwiegenden neurologischen Ausfallerscheinungen im Sinne einer Paraplegie oder Radikulopathie.
Dieser Artikel soll einerseits die in der Literatur dargestellten Komplikationen zusammenfassen, das derzeit gültige Therapiemanagement aufzeigen und Möglichkeiten beschreiben Komplikationen zu vermeiden bzw. deren Auftreten zu minimieren. Radiologische Befunde möglicher unerwünschter Zementaustritte aus dem eigenen Patientengut werden aufgezeigt.
Abstract
Percutaneous vertebroplasty was first introduced in 1984 by Galibert et al. for the treatment of hemangiomas in the spine. The current indications for vertebroplasty also include compression fractures due to osteoporosis as well as osteolytic metastases and spinal myeloma lesions.
With the numbers of percutaneous vertebroplasty performed by orthopedic and trauma surgeons, neurosurgeons, and radiologists steadily increasing, complications have also risen. Over the last 3 years an increasing number of cases with varying complications, their genesis, and their management have been reported in the literature. Complications include asymptomatic cement leakage, cardiovascular effects, embolism with lethal outcome as well as severe neurological deficits.
This article presents a review of the complications reported in the literature, strategies for preventing possible complications as well as current concepts in therapy management. Several of our cases with cement leakages are presented.
Literatur
Aebli N, Krebs J, Davis G, Walton M, Williams MJA, Theis J-C (2002) Fat embolism and acute hypotension during vertebroplasty. An experimental study in sheep. Spine 27: 460–466
Al-Assir I, Perez-Higueras A, Florensa J, Munoz A, Cuesta E (2000) Percutaneous vertebroplasty: A special syringe for cement injection. AJNR 21: 159–161
Barr JD, Barr MS, Lemley TJ, McCann M (2000) Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine 15: 923–928
Belkoff SM, Mathis JM, Jasper LE, Deramond H (2000) The biomechanics of vertebroplasty. The effect of cement volume on mechanical behavior. Spine 26 :1537–1541
Berlemann U, Ferguson SJ, Nolte LP, Heini PF (2002) Adjacent vertebral failure after vertebroplasty. A biomechanical investigation. J Bone Joint Surg Br 84: 748–752
Chen H-L, Wong C-S, Ho S-T, Chang F-L, Hsu C-H, Wu C-T (2002) A lethal pulmonary embolism during percutaneous vertebroplasty. Anesth Analg 95: 1060–1062
Cotten A, Dewatre F, Cortet B et al. (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: Effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 200: 525–530
Deramond H, Depriester C, Galibert P, Le Gars D (1998) Percutaneous vertebroplasty with polymethylmethacrylate. Technique, indications and results. Radiol Clin North Am 36: 533–546
Deramond H, Wright NT, Belkoff SM (1999) Temperature elevation caused by bone cement polymerization during vertebroplasty. Bone 25 (Suppl 2): 17–21
Finch L, Cheng SG, Steinberg KP, Stern EJ (2002) Polymethylmethacrylate pulmonary emboli. Clin Pulmon Med 9: 133–134
Galibert P, Deramond H, Rosat P, Le Gars D (1987) Note préliminaire sur le traitement des angiomes vertébraux par vertébroplastie percutanée. Neurochirurgie 33: 166–168
Garfin SR, Yuan HA, Reiley MA (2000) Kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 26: 1511–1514
Gangi A, Dietemann JL, Schultz A, Mortazavi R, Jeung MY, Roy C (1996) Interventional radiologic procedures with CT guidance in cancer pain management. Radiographics 16: 1289–1304
Gangi A, Dietemann JL, Mortazavi R, Pfleger D, Kauff C, Roy C (1998) CT-guided interventional procedures for pain management in the lumbosacral spine. Radiographics 18: 621–633
Gangi A, Dietemann JL, Guth S, Steib JP, Roy C (1999) Computed tomography (CT) and flouroscopy-guided vertebroplasty: results and complications in 187 patients. Sem Intervent Radiol 16: 137–142
Gaughen JR, Jensen ME, Schweickert PA, Kaufmann TJ, Marx WF, Kallmes DF (2002) Relevance of antedecent venography in percutaneous vertebroplasty for the treatment of osteoporotic compression fractures. AJNR 23: 594–600
Harrington KD (2001) Major neurological complications following percutaneous vertebroplasty with polymethylmethacrylate. J Bone Joint Surg Am 83: 1070–1073
Heini PF, Wälchli B, Berlemann U (2000) Percutaneous transpedicular vertebroplasty with pmma: operative technique and early results. A prospective study for the treatment of osteoporotic compression fractures. Eur Spine J 9: 445–450
Jang JS, Lee SH, Jung SK (2002) Pulmonary embolism of polymethylmethacrylate after percutaneous vertebroplasty: A report of three cases. Spine 27: 416–418
Jensen ME, Evans AJ, Mathis JM, Kallmes DF, Cloft HJ, Dion JE (1997) Percutaenous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. AJNR 18: 1897–1904
Kaufmann TJ, Jensen ME, Ford G, Gill LL, Marx WF, Kallmes DF (2002) Cardiovascular effects of polymethylmethacrylate use in percutaneous vertebroplasty. AJNR 23: 601–604
Lee B-J, Lee S-R, Yoo T-Y (2002) Paraplegia as a complication of percutaneous vertebroplasty with polymethylmethacrylate: a case report. Spine 27: 419–422
Padovani B, Kasriel O, Brunner P, Peretti-Viton P (1999) Pulmonary embolism caused by acrylic cement: A rare complication of percutaneous vertebroplasty. AJNR 20: 375–377
Piergiogio T, Abdelmoumenen Y, Corno AF, Gersbach PA, Hoogewoud HM, von Segesser K (2002) Management of pulmonary embolism during acrylic vertebroplasty. Ann Thorac Surg 74: 1706–1708
Ratliff J, Nguyen T, Heiss J (2001) Root and spinal cord compression from methylmethacrylate vertebroplasty. Spine 26: 300–302
Scroop R, Eskridge J, Britz GW (2002) Paradoxical cerebral arterial embolization of cement during intraoperative vertebroplasty: case report. AJNR 23: 868–870
Shapiro S, Abel T, Purvines S (2003) Surgical removal of epidural and intradural polymethylmetacrylate extravasation complicating percutaneous vertebroplasty for an osteoporotic lumbar compression fracture. Case report. J Neurosurg 98 (Suppl): 90–92
Tohmeh AG, Mathis JM, Fenton DC, Levine AM, Belkoff SM (1999) Biomechanical efficacy of unipedicular versus bipedicular vertebroplasty for the management of osteoporotic compression fractures. Spine 24: 1772–1776
Tozzi P, Abdelmoumene Y, Corno AF, Gersbach PA, Hoogewoud HM, Segesser LK (2002) Management of pulmonary embolism during acrylic vertebroplasty. Ann Thorac Surg 74: 17006–17008
Vasconcelos C, Gailloud P, Βeauchamp NJ, Heck DV, Murphy KJ (2002) Is percutaneous vertebroplasty without pretreatment venography safe? Evaluation of 205 consecutives procedures. AJNR 23: 913–917
Weill A, Chiras J, Simon JM, Rose M, Sola-Martinez T, Enkaoua E (1996) Spinal metastases: Indications for and results of percutaneous injection of acrylic surgical cement. Radiology 199: 241–247
Wenger M, Markwalder T-M (1999) Surgically controlled transpedicular methyl-methacrylate vertebroplasty with fluoroscopic guidance. Acta Neurochir 141: 625–631
Wenger M, Markwalder T-M (2002) Cement leakage and the need for prophylactic fenestration of the spinal canal during vertebroplasty. Letters to the editor. J Bone Joint Surg Am 84: 689
Zenker W (1985) Die Blutgefäße des Zentralnervensystemes. In: Beninghoff (Hrsg) Makroskopische und mikroskopische Anatomie des Menschen, Bd 3: Nervensystem, Haut und Sinnesorgane. Urban & Schwarzenberg, München, S 200–201
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Rauschmann, M.A., von Stechow, D., Thomann, KD. et al. Komplikationen in der Vertebroplastie. Orthopäde 33, 40–47 (2004). https://doi.org/10.1007/s00132-003-0573-4
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DOI: https://doi.org/10.1007/s00132-003-0573-4