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Update Folsäurestoffwechsel

Update on folic acid metabolism

  • Gynäkologie aktuell
  • Published:
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Zusammenfassung

Die Bedeutung einer ausreichenden Versorgung von jungen Frauen im reproduktionsfähigen Alter und von Schwangere ist mittlerweile Teil des Allgemeinwissens, und die Rate an Neuralrohrdefekten konnte effizient gesenkt werden. Doch damit ist die Bedeutung dieses wichtigen Spurenelementes durchaus nicht erschöpft. Thrombophile Zustände in der Schwangerschaft führen zu Plazentationsstörungen mit gehäuften Aborten, fetaler Wachstumsverzögerung und erhöhen das Risiko für Gestosen. Dass hier ein Stoffwechseldefekt im Folsäuremetabolismus eine wichtige Rolle spielt, ist allerdings nur wenig bekannt und erforscht. Der Beitrag beleuchtet neben Grundlagen des Folsäurestoffwechsels auch dessen klinische Bedeutung über die Neuralrohrdefekte hinaus und zeigt neue Ansätze zur optimalen Risikominderung von Schwangerschaftskomplikationen bei Folsäurestoffwechseldefekten auf.

Abstract

Sufficient intake of folic acid is an essential component of the nutrition of young fertile women and during pregnancy. The incidence of neural tube defects can be reduced dramatically; however, further meaningful aspects of folic acid function should be mentioned. Thrombophilic conditions during pregnancy result in placental disorders with recurrent miscarriage, intrauterine growth retardation and preeclampsia. Defects in folic acid metabolic pathways seem to play an important role in the development of these complications. This article focuses on the basic principles of folic acid metabolic pathways and polymorphisms and the clinical importance in the context of complications during pregnancy. New insights into this topic provide optimal risk reduction and patient care in folic acid metabolic defects.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. E. Edeler und A. Heubner geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    E. Edeler, A. Heubner, R. Kimmig & A. Köninger

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  1. E. Edeler
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  2. A. Heubner
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  3. R. Kimmig
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  4. A. Köninger
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Correspondence to E. Edeler or A. Heubner.

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Elisabeth Edeler und Antonia Heubner teilen die Erstautorenschaft.

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Edeler, E., Heubner, A., Kimmig, R. et al. Update Folsäurestoffwechsel. Gynäkologe 48, 159–163 (2015). https://doi.org/10.1007/s00129-014-3516-8

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  • DOI: https://doi.org/10.1007/s00129-014-3516-8

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