Skip to main content
Log in

Ovarielle Stimulation bei der prä- und perimenopausalen Patientin

Ovarian stimulation in premenopausal and perimenopausal patients

  • Leitthema
  • Published:
Der Gynäkologe Aims and scope

Zusammenfassung

Kinderwunschtherapien bei Frauen ab 40 Jahren haben eine begrenzte Erfolgschance. Die ovarielle Reserve und die Eizellqualität sind vermindert, die Chancen der „assisted reproduction technology“ (ART) kontinuierlich abnehmend. Die Stimulationsprotokolle zur ovariellen Stimulation unterscheiden sich nicht von denen bei jüngeren Patientinnen. Vorteile der verschiedenen Stimulationsprotokolle speziell für diese Altersgruppe konnten nicht gezeigt werden.

Abstract

Treatment of infertility in women over the age of 40 years is of limited success. The ovarian reserve is diminished in most cases as is the quality of oocytes and the chances of success with assisted reproduction technology (ART) steadily decrease with age. Stimulation protocols for controlled ovarian hyperstimulation (COH) are no different from those for younger patients. No advantages for any of the various stimulation protocols could be shown for this particular age group.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Almog B, Shehata F, Shalom-Paz E et al (2011) Age-related nomogram for antral follicle count: McGill reference guide. Fertil Steril 95:663–666

    Article  PubMed  Google Scholar 

  2. Almog B, Shehata F, Suissa S et al (2011) Age-related nomograms of serum antimüllerian hormone levels in a population of infertile women: a multicenter study. Fertil Steril 95:2359–2363

    Article  CAS  PubMed  Google Scholar 

  3. Baart EB, Martini E, Eijkemans MJ et al (2007) Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 22:980–988

    Article  PubMed  Google Scholar 

  4. Berkkanoglu M, Ozgur K (2010) What is the optimum maximal gonadotropin dosage used in microdose flare-up cycles in poor responders? Fertil Steril 94:662–665

    Article  CAS  PubMed  Google Scholar 

  5. Broekmans FJ, Soules MR, Fauser BC (2009) Ovarian aging: mechanisms and clinical consequences. Endocr Rev 30:465–493

    Article  CAS  PubMed  Google Scholar 

  6. Broer SL, Disseldorp J van, Broeze KA et al (2013) Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach. Hum Reprod Update 19:26–36

    Article  PubMed  Google Scholar 

  7. Check JH, Choe JK, Cohen R, Wilson C (2013) A study to determine the efficacy of controlled ovarian hyperstimulation regimen using a gonadotropin releasing hormone agonist versus antagonist in women of advanced reproductive age with varying degrees of oocyte reserve on outcome following in vitro fertilization-embryo transfer. Clin Exp Obstet Gynecol 40:191–192

    CAS  PubMed  Google Scholar 

  8. DIR: http://www.deutsches-ivf-register.de

  9. Dunson DB, Colombo B, Baird DD (2002) Changes with age in the level and duration of fertility in the menstrual cycle. Hum Reprod 17:1399–1403

    Article  PubMed  Google Scholar 

  10. Fauser BC, Diedrich K, Devroey P (2008) Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation. Hum Reprod Update 14:1–14

    Article  CAS  PubMed  Google Scholar 

  11. Ferraretti AP, La Marca A, Fauser BC et al (2011) ESHRE consensus on the definition of ‚poor response‘ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 26:1616–1624

    Article  CAS  PubMed  Google Scholar 

  12. Gleicher N, Barad DH (2011) Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reprod Biol Endocrinol 9:67–79

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Gougeon A (1998) Ovarian follicular growth in humans: ovarian ageing and population of growing follicles. Maturitas 30:137–142

    Article  CAS  PubMed  Google Scholar 

  14. Hill MJ, Levy G, Levens ED (2012) Does exogenous LH in ovarian stimulation improve assisted reproduction success? An appraisal of the literature. Reprod Biomed Online 24:261–271

    Article  CAS  PubMed  Google Scholar 

  15. Hourvitz A, Machtinger R, Maman E et al (2009) Assisted reproduction in women over 40 years of age: how old is too old? Reprod Biomed Online 19:599–603

    Article  PubMed  Google Scholar 

  16. Klinkert ER, Broekmans FJ, Looman CW et al (2005) Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial. Hum Reprod 20:611–615

    Article  CAS  PubMed  Google Scholar 

  17. Kucuk T, Kozinoglu H, Kaba A (2008) Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial. J Assist Reprod Genet 25:123–127

    Article  PubMed Central  PubMed  Google Scholar 

  18. La Marca A, Sighinolfi G, Radi D et al (2010) Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update 16:113–130

    Article  Google Scholar 

  19. La Marca A, Spada E, Sighinolfi G et al (2011) Age-specific nomogram for the decline in antral follicle count throughout the reproductive period. Fertil Steril 95:684–688

    Article  Google Scholar 

  20. Leridon H (2004) Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment. Hum Reprod 19:1548–1553

    Article  PubMed  Google Scholar 

  21. Lossl K, Andersen CY, Loft A et al (2008) Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial. Hum Reprod 23:1820–1829

    Article  CAS  PubMed  Google Scholar 

  22. Nardo LG, Bosch E, Lambalk CB, Gelbaya TA (2013) Controlled ovarian hyperstimulation regimens: a review of the available evidence for clinical practice. Produced on behalf of the BFS Policy and Practice Committee. Hum Fertil (Camb) 16:144–150

    Google Scholar 

  23. Pandian Z, McTavish AR, Aucott L et al (2010) Interventions for „poor responders“ to controlled ovarian hyper stimulation (COH) in in-vitro fertilisation (IVF). Cochrane Database Syst Rev:CD004379. DOI 10.1002/14651858.CD004379.pub3

    Google Scholar 

  24. Pu D, Wu J, Liu J (2011) Comparisons of GnRH antagonist versus GnRH agonist protocol in poor ovarian responders undergoing IVF. Hum Reprod 26:2742–2749

    Article  CAS  PubMed  Google Scholar 

  25. Spandorfer SD, Bendikson K, Dragisic K et al (2007) Outcome of in vitro fertilization in women 45 years and older who use autologous oocytes. Fertil Steril 87:74–76

    Article  PubMed  Google Scholar 

  26. Tokura Y, Yoshino O, Ogura-Nose S et al (2013) The significance of serum anti-Müllerian hormone (AMH) levels in patients over age 40 in first IVF treatment. J Assist Reprod Genet 30:821–825

    Article  PubMed  Google Scholar 

  27. Disseldorp J van, Faddy MJ, Themmen AP et al (2008) Relationship of serum antimüllerian hormone concentration to age at menopause. J Clin Endocrinol Metab 93:2129–2134

    Article  PubMed  Google Scholar 

  28. Rooij IA van, Bancsi LF, Broekmans FJ et al (2003) Women older than 40 years of age and those with elevated follicle-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization. Fertil Steril 79:482–488

    Article  PubMed  Google Scholar 

  29. Wiser A, Gonen O, Ghetler Y et al (2010) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod 25:2496–2500

    Article  CAS  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Strowitzki und M. von Wolff geben an, dass kein Interessenkonflikt besteht. Der Beitrag enthält keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Strowitzki.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strowitzki, T., von Wolff, M. Ovarielle Stimulation bei der prä- und perimenopausalen Patientin. Gynäkologe 47, 258–262 (2014). https://doi.org/10.1007/s00129-013-3269-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00129-013-3269-9

Schlüsselwörter

Keywords

Navigation