Skip to main content
Log in

Zervixkarzinom in der Schwangerschaft

Zwischen optimaler Therapie und Schwangerschaftserhalt

Cervical cancer during pregnancy

Between optimal therapy and preservation of pregnancy

  • Leitthema
  • Published:
Der Gynäkologe Aims and scope

Zusammenfassung

Das Zervixkarzinom ist das zweithäufigste in der Schwangerschaft diagnostizierte Karzinom. Während das invasive Zervixkarzinom in graviditate selten ist, sind auffällige PAP-Abstriche und Krebsvorstufen in der Schwangerschaft in der Praxis ein häufiges Problem. Der vorliegende Beitrag erläutert die praktische Vorgehensweise bei suspekter Zervixzytologie in der Schwangerschaft. Darüber hinaus werden Stadien- und Gestationsalter-abhängige Therapieoptionen beim invasiven Zervixkarzinom in der Schwangerschaft unter Rücksichtnahme auf den Erhalt der Schwangerschaft aufgezeigt.

Abstract

Carcinoma of the cervix uteri is the second most diagnosed cancer during pregnancy. Although gestational cervical cancer is rare abnormal PAP smears and preinvasive lesions are frequently found during pregnancy. The present article depicts a practical approach to preinvasive cervical lesions during pregnancy. Furthermore, therapeutic options in cases of invasive cervical carcinoma diagnosed during pregnancy are presented according to the gestational stage and cancer stage, taking into account pregnancy preservation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Ferriaoli D, Buenerd A, Marchiole P et al (2012) Early invasive cervical cancer during pregnancy: different therapeutic options to preserve fertility. Int J Gynecol Cancer 22(5):842–849

    Article  PubMed  Google Scholar 

  2. Morice P, Uzan C, Gouy S et al (2012) Gynaecological cancers in pregnancy. Lancet 379(9815):558–569

    Article  PubMed  Google Scholar 

  3. Robert-Koch-Institut (2012) http://www.krebsdaten.de/Krebs/DE/Content/Krebsarten/Gebaermutterhalskrebs/gebaermutterhalskrebs_node.html. (Zugegriffen: 29. Oktober 2012)

  4. Merimsky O, Le Chevalier T, Missenard G et al (1999) Management of cancer in pregnancy: a case of Ewing’s sarcoma of the pelvis in the third trimester. Ann Oncol 10(3):345–350

    Article  PubMed  CAS  Google Scholar 

  5. Hoellen F, Reibke R, Hornemann K et al (2012) Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies. Arch Gynecol Obstet 285(1):195–205

    Article  PubMed  CAS  Google Scholar 

  6. Fleury AC, Birsner ML, Fader AN (2012) Management of the abnormal Papanicolaou smear and colposcopy in pregnancy: an evidenced-based review. Minerva Ginecol 64(2):137–148

    PubMed  CAS  Google Scholar 

  7. Connolly TP, Evans AC (2005) Atypical Papanicolaou smear in pregnancy. Clin Med Res 3(1):13–18 (PMCID: 1142102)

    Google Scholar 

  8. Cubo-Abert M, Centeno-Mediavilla C, Franco-Zabala P et al (2012) Risk factors for progression or persistence of squamous intraepithelial lesions diagnosed during pregnancy. J Low Genit Tract Dis 16(1):34–38

    Article  PubMed  Google Scholar 

  9. Schaefer K, Peters D, Aulmann S et al (2012) Value and feasibility of LLETZ procedures for pregnant women with suspected high-grade squamous intraepithelial lesions and microinvasive Zervical cancer. Int J Gynaecol Obstet 118(2):141–144

    Article  PubMed  Google Scholar 

  10. Goncalves CV, Duarte G, Costa JS et al (2009) Diagnosis and treatment of cervical cancer during pregnancy. Sao Paulo Med J 127(6):359–365

    Article  PubMed  Google Scholar 

  11. Pavlidis NA (2000) Cancer and pregnancy. Ann Oncol 11(Suppl 3):247–253

    PubMed  Google Scholar 

  12. Arbeitsghemeinschaft Gynäkologische Onkologie, AGO (2009) http://www.ago-online.de/fileadmin/downloads/leitlinien/uterus/s2_leitlinie_cx_ca_090204.pdf. (Zugegriffen: 29. Oktober 2012)

  13. DGGG (2008) Deutsche Gesellschaft für Gynäkologie und Geburtshilfe e. V. Leitlinien, Empfehlungen, Stellungnahmen

  14. Mangler M, Speiser D, Nguyen BD et al (2012) Neonatal outcome in infants of patients with radical vaginal trachelectomy. J Perinat Med 0(0):1–7

    PubMed  Google Scholar 

  15. Azim HA Jr, Peccatori FA, Pavlidis N (2010) Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: solid tumors. Cancer Treat Rev 36(2):101–109

    Article  PubMed  CAS  Google Scholar 

  16. Serkies K, Wegrzynowicz E, Jassem J (2011) Paclitaxel and cisplatin chemotherapy for ovarian cancer during pregnancy: case report and review of the literature. Arch Gynecol Obstet 283(Suppl 1):97–100

    Article  PubMed  Google Scholar 

  17. Mir O, Berveiller P, Ropert S et al (2008) Use of platinum derivatives during pregnancy. Cancer 113(11):3069–3074

    Article  PubMed  CAS  Google Scholar 

  18. Morice P, Narducci F, Mathevet P et al (2009) French recommendations on the management of invasive cervical cancer during pregnancy. Int J Gynecol Cancer 19(9):1638–1641

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F. Hoellen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoellen, F., Diedrich, K., Beyer, D. et al. Zervixkarzinom in der Schwangerschaft. Gynäkologe 45, 939–944 (2012). https://doi.org/10.1007/s00129-012-3028-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00129-012-3028-3

Schlüsselwörter

Keywords

Navigation