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Schwangerschaft nach onkologischen Erkrankungen

Pregnancy after oncological diseases

  • Leitthema
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Der Gynäkologe Aims and scope

Zusammenfassung

Aufgrund der soziokulturellen Veränderungen mit später Familienplanung und verbesserten onkologischen Therapien werden Onkologen, Gynäkologen und Geburtshelfer zunehmend mit der Thematik Kinderwunsch nach onkologischer Therapie konfrontiert. Retrospektive Studien konnten zeigen, dass eine Schwangerschaft generell keinen ungünstigen Einfluss auf die Prognose und das Rezidivrisiko einer Krebserkrankung nach abgeschlossener onkologischer Therapie hat. Auch das Risiko fetaler Malformationen und teratogener Einflüsse nach abgeschlossener Chemotherapie, Strahlentherapie oder endokriner Therapie ist gegenüber dem Normalkollektiv nicht erhöht. Das Thema Kinderwunsch muss individuell mit der Patientin diskutiert werden und entsprechend Tumorentität, Tumorstadium und Tumorcharakteristiken beleuchtet werden.

Abstract

With regard to sociocultural changes and the tendency for women to postpone childbirth as well as improved oncological therapy, oncologists, gynecologists and obstetricians are more often faced with oncology patients wishing to become pregnant after oncological therapy. Some retrospective studies have demonstrated that pregnancy does not have an unfavorable effect on the prognosis and does not increase the risk of cancer recurrence after completed oncological therapy. The risk of fetal malformation or teratogenic effects is also not elevated after completed chemotherapy, radiation or endocrine therapy in comparison to a healthy control group. Patients wishing to become pregnant after completed oncological therapy must be counseled individually with regard to the tumor entity, tumor stage and tumor characteristics.

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Literatur

  1. Pentheroudakis G, Orecchia R, Hoekstra HJ et al (2010) Cancer, fertility and pregnancy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(Suppl 5):v266–273

    Article  PubMed  Google Scholar 

  2. Valachis A, Tsali L, Pesce LL et al (2010) Safety of pregnancy after primary breast carcinoma in young women: a meta-analysis to overcome bias of healthy mother effect studies. Obstet Gynecol Surv 65(12):786–793

    Article  PubMed  Google Scholar 

  3. Pagani O, Partridge A, Korde L et al (2011) Pregnancy after breast cancer: if you wish, ma’am. Breast Cancer Res Treat 129(2):309–317

    Article  PubMed  Google Scholar 

  4. Ives A, Saunders C, Bulsara M et al (2007) Pregnancy after breast cancer: population based study. BMJ 334(7586):194

    Article  PubMed  Google Scholar 

  5. Lawrenz B, Banys M, Henes M et al (2011) Pregnancy after breast cancer: case report and review of the literature. Arch Gynecol Obstet 283(4):837–843

    Article  PubMed  Google Scholar 

  6. Largillier R, Savignoni A, Gligorov J et al (2009) Prognostic role of pregnancy occurring before or after treatment of early breast cancer patients aged <35 years: a GET(N)A Working Group analysis. Cancer 115(22):5155–5165

    Article  PubMed  Google Scholar 

  7. Koca T, Akgun Z, Yucel SB et al (2011) Pregnancy a short time after multimodal therapy for bilateral breast cancer: a case report and review of literature. J Oncol Pharm Pract 17(4):440–443

    Article  PubMed  CAS  Google Scholar 

  8. Braems G, Denys H, De Wever O et al (2011) Use of tamoxifen before and during pregnancy. Oncologist 16(11):1547–1551

    Article  PubMed  CAS  Google Scholar 

  9. Diedrich K, Fauser BC, Devroey P (2011) Cancer and fertility: strategies to preserve fertility. Reprod Biomed Online 22(3):232–248

    Article  PubMed  CAS  Google Scholar 

  10. Vernaeve V, Bodri D, Colodron M et al (2007) Endometrial receptivity after oocyte donation in recipients with a history of chemotherapy and/or radiotherapy. Hum Reprod 22(11):2863–2867

    Article  PubMed  Google Scholar 

  11. Lawrenz B, Henes M, Neunhoeffer E et al (2012) Pregnancy after successful cancer treatment: what needs to be considered? Onkologie 35(3):128–132

    Article  PubMed  Google Scholar 

  12. Dalberg K, Eriksson J, Holmberg L (2006) Birth outcome in women with previously treated breast cancer − a population-based cohort study from Sweden. PLoS Med 3(9):e336

    Article  PubMed  Google Scholar 

  13. Massey Skatulla L, Loibl S et al (2012) Pre-eclampsia following chemotherapy for breast cancer during pregnancy: case report and review of the literature. Arch Gynecol Obstet 286(1):89–92

    Article  Google Scholar 

  14. Azim HA Jr, Metzger-Filho O, Azambuja E de et al (2012) Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01–01). Breast Cancer Res Treat 133(1):387–391

    Article  PubMed  CAS  Google Scholar 

  15. Shah AJ (2011) Successful pregnancy after busulfan/cytoxan conditioning regimen for AML. J Pediatr Hematol Oncol 33(5):e180–181

    Article  PubMed  Google Scholar 

  16. Loren AW, Chow E, Jacobsohn DA et al (2011) Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR). Biol Blood Marrow Transplant 17(2):157–166

    Article  PubMed  Google Scholar 

  17. Kontzoglou K, Stamatakos M, Tsaknaki S et al (2009) Successful pregnancy after breast cancer therapy: dream or reality? Int Semin Surg Oncol 6:7

    Article  PubMed  Google Scholar 

  18. De Sanctis V, Filippone FR, Alfo M et al (2012) Impact of different treatment approaches on pregnancy outcomes in 99 women treated for hodgkin lymphoma. Int J Radiat Oncol Biol Phys (epub before print)

  19. Mangler M, Speiser D, Nguyen BD et al (2012) Neonatal outcome in infants of patients with radical vaginal trachelectomy. J Perinat Med 0(0):1–7

    PubMed  Google Scholar 

  20. Speiser D, Mangler M, Kohler C et al (2011) Fertility outcome after radical vaginal trachelectomy: a prospective study of 212 patients. Int J Gynecol Cancer 21(9):1635–1639

    Article  PubMed  Google Scholar 

  21. Kim CH, Abu-Rustum NR, Chi DS et al (2012) Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer. Gynecol Oncol 125(3):585–588

    Article  PubMed  CAS  Google Scholar 

  22. Li J, Li Z, Wang H et al (2011) Radical abdominal trachelectomy for cervical malignancies: surgical, oncological and fertility outcomes in 62 patients. Gynecol Oncol 121(3):565–570

    Article  PubMed  Google Scholar 

  23. Jolley JA, Battista L, Wing DA (2007) Management of pregnancy after radical trachelectomy: case reports and systematic review of the literature. Am J Perinatol 24(9):531–539

    Article  PubMed  Google Scholar 

  24. Lee KY, Jun HA, Roh JW et al (2007) Successful twin pregnancy after vaginal radical hysterectomy using transabdominal cervicoisthmic cerclage. Am J Obstet Gynecol 197(3):e5–6

    Article  PubMed  Google Scholar 

  25. Palmer JE, Tidy JA (2009) Pregnancy following vulvar squamous cell carcinoma: a report of two cases. J Gynecol Oncol 20(4):254–256

    Article  PubMed  Google Scholar 

  26. http://www.ago-online.de/de/fuer-mediziner/leitlinien/ovar/

  27. Colombo N, Parma G, Lapresa MT et al (2005) Role of conservative surgery of ovarian cancer: the European experience. Int J Gynecol Cancer 15(Suppl 3):206–211

    Article  PubMed  Google Scholar 

  28. Zanetta G, Chiara S, Rota S et al (1997) Conservative surgery for stage I ovarian carcinomas in women of childbearing age. Br J Obstet Gynaecol 104:1030−1035

    Article  PubMed  CAS  Google Scholar 

  29. Raspagliesi F, Fontanelli R, Paladini D, de Re EM (1997) Conservative surgery in high risk epithelial ovarian carcinoma. Am J Coll Surg 185:457−460

    CAS  Google Scholar 

  30. Morice P, Leblanc E, Rey A et al (2005) Conservative treatment in epithelial ovarian cancer − results of a multicentre study GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Française d’Oncologie Gynécologique). Hum Reprod 20: 1379−1385

    Article  PubMed  CAS  Google Scholar 

  31. Schilder JM, Thompson AM, DePriest PD et al (2002) Outcome of reproductive age woman with stage IA or IC invasive epithelian ovarian cancer treated with fertility-sparing therapy. Gynecol Oncol 87:1–7

    Article  PubMed  Google Scholar 

  32. Cheng X, Cheng B, Wan X et al (2012) Outcomes of conservative surgery in early epithelial ovarian carcinoma. Eur J Gynaecol Oncol 33(1):93–95

    Article  PubMed  CAS  Google Scholar 

  33. Bree E de, Makrigiannakis A, Askoxylakis J et al (2010) Pregnancy after breast cancer. A comprehensive review. J Surg Oncol 101(6):534–542

    Article  PubMed  Google Scholar 

  34. Surbone A, Peccatori F, Pavlidis N (2008) Why is the topic of cancer and pregnancy so important? Why and how to read this book. Recent Results Cancer Res 178:1–2

    Article  PubMed  CAS  Google Scholar 

  35. Hahn KM, Johnson PH, Gordon N et al (2006) Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer 107(6):1219–1226

    Article  PubMed  Google Scholar 

  36. Kranick JA, Schaefer C, Rowell S et al (2010) Is pregnancy after breast cancer safe? Breast J 16(4):404–411

    PubMed  Google Scholar 

  37. Stensheim H (2009) Malignant melanoma and pregnancy. Onkologie 32(12):715–716

    Article  PubMed  Google Scholar 

  38. Cleator SJ, Ahamed E, Coombes RC et al (2009) A 2009 update on the treatment of patients with hormone receptor-positive breast cancer. Clin Breast Cancer 9(Suppl 1):6–17

    Article  Google Scholar 

  39. Vannucchi G, Perrino M, Rossi S et al (2010) Clinical and molecular features of differentiated thyroid cancer diagnosed during pregnancy. Eur J Endocrinol 162(1):145–151

    Article  PubMed  CAS  Google Scholar 

  40. Khochikar MV (2010) Management of urological cancers during pregnancy. Nat Rev Urol 7(4):195–205

    Article  PubMed  Google Scholar 

  41. Kroman N, Jensen MB, Wohlfahrt J et al (2008) Pregnancy after treatment of breast cancer–a population-based study on behalf of Danish Breast Cancer Cooperative Group. Acta Oncol 7(4):545–549

    Article  Google Scholar 

  42. Verkooijen HM, Lim GH, Czene K et al (2010) Effect of childbirth after treatment on long-term survival from breast cancer. Br J Surg 97(8):1253–1259

    Article  PubMed  CAS  Google Scholar 

  43. Rippy EE, Karat IF, Kissin MW (2009) Pregnancy after breast cancer: the importance of active counselling and planning. Breast 18(6):345–350

    Article  PubMed  CAS  Google Scholar 

  44. Schnabel F, Billig J, Cimeno A et al (2012) Pregnancy-associated breast cancer and increased risk of pregnancy-associated recurrence: a case report. J Med Case Rep 6(1):144

    Article  PubMed  Google Scholar 

  45. Cordoba O, Bellet M, Vidal X et al (2012) Pregnancy after treatment of breast cancer in young women does not adversely affect the prognosis. Breast 21(3):272–275

    Article  PubMed  Google Scholar 

  46. Hoellen F, Reibke R, Hornemann K et al (2012) Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies. Arch Gynecol Obstet 285(1):195–205

    Article  PubMed  CAS  Google Scholar 

  47. Braun M, Hasson-Ohayon I, Perry S et al (2005) Motivation for giving birth after breast cancer. Psychooncology 14(4):282–296

    Article  PubMed  Google Scholar 

  48. Gorman JR, Roesch SC, Parker BA et al (2010) Physical and mental health correlates of pregnancy following breast cancer. Psychooncology 19(5):517–524

    Article  PubMed  Google Scholar 

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Thill, M., Baumann, K., Diedrich, K. et al. Schwangerschaft nach onkologischen Erkrankungen. Gynäkologe 45, 945–950 (2012). https://doi.org/10.1007/s00129-012-3027-4

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  • DOI: https://doi.org/10.1007/s00129-012-3027-4

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