Zusammenfassung
Ein Mammakarzinom tritt bei etwa 1% in der Schwangerschaft auf. Aufgrund der Seltenheit und der besonderen Umstände stammen die meisten Daten aus Fallserien und Kohortenstudien. Die Frauen sollen und können so nah wie möglich am Standard für junge nichtschwangere Mammakarzinompatientinnen behandelt werden. Alle Patientinnen mit Mammakarzinom in der Schwangerschaft sollten der GBG(German Breast Group)-Registerstudie gemeldet werden (http://www.germanbreastgroup.de/pregnancy).
Abstract
Breast cancer is diagnosed during pregnancy in 1% of cases. Today it is recommended that these patients should be treated as closely as possible to the standard for young non-pregnant women. All patients with breast cancer during pregnancy should be included in the register of the German Breast Group http://www.germanbreastgroup.de/pregnancy.
Literatur
Aebi S, Loibl S (2008) Breast cancer during pregnancy. Recent Results Cancer Res 178:45–55
Amant F, Deckers S, Van Calsteren K et al (2010) Breast cancer in pregnancy: recommendations of an international consensus meeting. Eur J Cancer 46:3158–3168
Amant F, Loibl S, Neven P, Van Calsteren K (2012) Breast cancer in pregnancy. Lancet 379(9815):570–579
Amant F, Van Calsteren K, Halaska MJ et al (2012) Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study. Lancet Oncol 13:256–64
Anders CK, Hsu DS, Broadwater G et al (2008) Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 26:3324–3330
Aviles A, Neri N (2001) Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma 2:173–177
Azim HA Jr, Metzger-Filho O, Azambuja E de et al (2012) Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01–01). Breast Cancer Res Treat 133:387–391
Berry DL, Theriault RL, Holmes FA et al (1999) Management of breast cancer during pregnancy using a standardized protocol. J Clin Oncol 17:855–861
Cardonick E, Bhat A, Gilmandyar D, Somer R (2012) Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy: case series and review of the literature. Ann Oncol (Epub ahead of print)
Crivellaro M, Senna G, Dama A et al (2003) Anaphylaxis due to patent blue dye during lymphography, with negative skin prick test. J Investig Allergol Clin Immunol 13:71–72
Cunha GR, Taguchi O, Namikawa R et al (1987) Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract. Hum Pathol 18:1132–1143
Dominici LS, Kuerer HM, Babiera G et al (2010) Wound complications from surgery in Pregnancy-Associated Breast Cancer (PABC). Breast Dis 31:1–5
Gentilini O, Cremonesi M, Toesca A et al (2010) Sentinel lymph node biopsy in pregnant patients with breast cancer. Eur J Nucl Med Mol Imaging 37:78–83
Gentilini O, Cremonesi M, Trifiro G (2004) Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 15:1348–1351
Halaska MJ, Pentheroudakis G, Strnad P et al (2009) Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study. Breast J 15:461–467
Hebert-Croteau N, Freeman CR, Latreille J et al (2004) A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer. Breast Cancer Res Treat 88:187–196
Kal HB, Struikmans H (2005) Radiotherapy during pregnancy: fact and fiction. Lancet Oncol 6:328–333
Kanal E, Barkovich AJ, Bell C et al (2007) ACR guidance document for safe MR practices. Am J Roentgenol 188:1447–1474
DeRoo LA, Cummings P, Müller BA et al (2007) Smoking before the first pregnancy and the risk of breast cancer: a meta-analysis. Am J Epidemiol 174:390–402
Loibl S (2008) New therapeutic options for breast cancer during pregnancy. Breast Care 3:171–176
Loibl S, Han SN, Amant F (2012) Being pregnant and diagnosed with breast cancer. Breast Care (Basel) 7(3):204–209
Loibl S, Han SN, Minckwitz G von et al (2012) Treatment of Breast Cancer during pregnancy. Lancet Oncol (epub ahead of print)
Loibl S, Minckwitz G von, Gwyn K et al (2006) Breast carcinoma during pregnancy. Recommendations from an International Expert Meeting. Cancer 106:237–246
Massey Skatulla L, Loibl S, Schauf B, Müller T (2012) Pre-eclampsia following chemotherapy for breast cancer during pregnancy: case report and review of the literature. Arch Gynecol Obstet 286:89–92
Mir O, Berveiller P, Goffinet F et al (2010) Taxanes for breast cancer during pregnancy: a systematic review. Ann Oncol21:425–426
Mondi MM, Cuenca RE, Ollila DW et al (2007) Sentinel lymph node biopsy during pregnancy: initial clinical experience. Ann Surg Oncol 14:218–221
Smit JW, Huisman MT, Tellingen O van et al (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest 104:1441–1447
Stensheim H, Moller B, Dijk T van, Fossa SD (2009) Cause specific survival for women diagnosed with cancer during pregnancy and lactation: a registry based cohort study. J Clin Oncol 27:45–51
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Loibl, S. Mammakarzinom in der Schwangerschaft. Gynäkologe 45, 927–932 (2012). https://doi.org/10.1007/s00129-012-3026-5
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DOI: https://doi.org/10.1007/s00129-012-3026-5