Skip to main content
Log in

Mammakarzinom in der Schwangerschaft

Breast cancer during pregnancy

  • Leitthema
  • Published:
Der Gynäkologe Aims and scope

Zusammenfassung

Ein Mammakarzinom tritt bei etwa 1% in der Schwangerschaft auf. Aufgrund der Seltenheit und der besonderen Umstände stammen die meisten Daten aus Fallserien und Kohortenstudien. Die Frauen sollen und können so nah wie möglich am Standard für junge nichtschwangere Mammakarzinompatientinnen behandelt werden. Alle Patientinnen mit Mammakarzinom in der Schwangerschaft sollten der GBG(German Breast Group)-Registerstudie gemeldet werden (http://www.germanbreastgroup.de/pregnancy).

Abstract

Breast cancer is diagnosed during pregnancy in 1% of cases. Today it is recommended that these patients should be treated as closely as possible to the standard for young non-pregnant women. All patients with breast cancer during pregnancy should be included in the register of the German Breast Group http://www.germanbreastgroup.de/pregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Aebi S, Loibl S (2008) Breast cancer during pregnancy. Recent Results Cancer Res 178:45–55

    Article  PubMed  CAS  Google Scholar 

  2. Amant F, Deckers S, Van Calsteren K et al (2010) Breast cancer in pregnancy: recommendations of an international consensus meeting. Eur J Cancer 46:3158–3168

    Article  PubMed  Google Scholar 

  3. Amant F, Loibl S, Neven P, Van Calsteren K (2012) Breast cancer in pregnancy. Lancet 379(9815):570–579

    Article  PubMed  Google Scholar 

  4. Amant F, Van Calsteren K, Halaska MJ et al (2012) Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study. Lancet Oncol 13:256–64

    Article  PubMed  CAS  Google Scholar 

  5. Anders CK, Hsu DS, Broadwater G et al (2008) Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 26:3324–3330

    Article  PubMed  Google Scholar 

  6. Aviles A, Neri N (2001) Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma 2:173–177

    Article  PubMed  CAS  Google Scholar 

  7. Azim HA Jr, Metzger-Filho O, Azambuja E de et al (2012) Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01–01). Breast Cancer Res Treat 133:387–391

    Article  PubMed  CAS  Google Scholar 

  8. Berry DL, Theriault RL, Holmes FA et al (1999) Management of breast cancer during pregnancy using a standardized protocol. J Clin Oncol 17:855–861

    PubMed  CAS  Google Scholar 

  9. Cardonick E, Bhat A, Gilmandyar D, Somer R (2012) Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy: case series and review of the literature. Ann Oncol (Epub ahead of print)

  10. Crivellaro M, Senna G, Dama A et al (2003) Anaphylaxis due to patent blue dye during lymphography, with negative skin prick test. J Investig Allergol Clin Immunol 13:71–72

    PubMed  Google Scholar 

  11. Cunha GR, Taguchi O, Namikawa R et al (1987) Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract. Hum Pathol 18:1132–1143

    Article  PubMed  CAS  Google Scholar 

  12. Dominici LS, Kuerer HM, Babiera G et al (2010) Wound complications from surgery in Pregnancy-Associated Breast Cancer (PABC). Breast Dis 31:1–5

    PubMed  Google Scholar 

  13. Gentilini O, Cremonesi M, Toesca A et al (2010) Sentinel lymph node biopsy in pregnant patients with breast cancer. Eur J Nucl Med Mol Imaging 37:78–83

    Article  PubMed  Google Scholar 

  14. Gentilini O, Cremonesi M, Trifiro G (2004) Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 15:1348–1351

    Article  PubMed  CAS  Google Scholar 

  15. Halaska MJ, Pentheroudakis G, Strnad P et al (2009) Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study. Breast J 15:461–467

    Article  PubMed  Google Scholar 

  16. Hebert-Croteau N, Freeman CR, Latreille J et al (2004) A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer. Breast Cancer Res Treat 88:187–196

    Article  PubMed  Google Scholar 

  17. Kal HB, Struikmans H (2005) Radiotherapy during pregnancy: fact and fiction. Lancet Oncol 6:328–333

    Article  PubMed  Google Scholar 

  18. Kanal E, Barkovich AJ, Bell C et al (2007) ACR guidance document for safe MR practices. Am J Roentgenol 188:1447–1474

    Article  Google Scholar 

  19. DeRoo LA, Cummings P, Müller BA et al (2007) Smoking before the first pregnancy and the risk of breast cancer: a meta-analysis. Am J Epidemiol 174:390–402

    Article  Google Scholar 

  20. Loibl S (2008) New therapeutic options for breast cancer during pregnancy. Breast Care 3:171–176

    Article  PubMed  Google Scholar 

  21. Loibl S, Han SN, Amant F (2012) Being pregnant and diagnosed with breast cancer. Breast Care (Basel) 7(3):204–209

    Google Scholar 

  22. Loibl S, Han SN, Minckwitz G von et al (2012) Treatment of Breast Cancer during pregnancy. Lancet Oncol (epub ahead of print)

  23. Loibl S, Minckwitz G von, Gwyn K et al (2006) Breast carcinoma during pregnancy. Recommendations from an International Expert Meeting. Cancer 106:237–246

    Article  PubMed  Google Scholar 

  24. Massey Skatulla L, Loibl S, Schauf B, Müller T (2012) Pre-eclampsia following chemotherapy for breast cancer during pregnancy: case report and review of the literature. Arch Gynecol Obstet 286:89–92

    Article  Google Scholar 

  25. Mir O, Berveiller P, Goffinet F et al (2010) Taxanes for breast cancer during pregnancy: a systematic review. Ann Oncol21:425–426

    Google Scholar 

  26. Mondi MM, Cuenca RE, Ollila DW et al (2007) Sentinel lymph node biopsy during pregnancy: initial clinical experience. Ann Surg Oncol 14:218–221

    Article  PubMed  Google Scholar 

  27. Smit JW, Huisman MT, Tellingen O van et al (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest 104:1441–1447

    Article  PubMed  CAS  Google Scholar 

  28. Stensheim H, Moller B, Dijk T van, Fossa SD (2009) Cause specific survival for women diagnosed with cancer during pregnancy and lactation: a registry based cohort study. J Clin Oncol 27:45–51

    Article  PubMed  Google Scholar 

  29. http://www.ago-online.de/

  30. http://www.RKI.de

Download references

Interessenskonflikt

Die korrespondierende Autorin gibt für sich und ihre Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Loibl.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Loibl, S. Mammakarzinom in der Schwangerschaft. Gynäkologe 45, 927–932 (2012). https://doi.org/10.1007/s00129-012-3026-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00129-012-3026-5

Schlüsselwörter

Keywords

Navigation