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Strahlentherapie

Radiation therapy

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Zusammenfassung

Die am S3-Leitlinien-Update beteiligten Radioonkologen hatten fachgebietsbezogen unter Einbeziehung aktueller Daten und radioonkologischer Konzepte einen daraus abgeleiteten Änderungsbedarf für die Primärtherapie, beim lokalen/lokoregionalen Rückfall und bei Metastasierung anzugeben. Aktualisierungen zu den Indikationen für eine Strahlentherapie (RT) betreffen Zielvolumina bei lokoregionalem Befall, Teilbrustbestrahlungen einschließlich (alleiniger) intraoperativer RT, Hypofraktionierungskonzepte, Kombination mit Systemtherapien i. R. der Primärtherapie und Einsatz bei lokoregionalem Rückfall und Organmetastasierung. Gemäß den methodischen Vorgaben des Update-Verfahrens wurde die Gültigkeit bestehender RT-Indikationen weitgehend durch Adaptation vorgegebener ausgewählter Leitlinien überprüft. Im Adaptationsverfahren werden aufgrund des zeitlichen Abstandes zum zurückliegenden Publikationsdatum der Quell-Leitlinien die aktuellsten Studiendaten durch das Wissen der nominierten Experten eingebracht, um Empfehlungen eventuell modifizieren zu können. Die im multidisziplinären sektorenübergreifenden Konsensus erstellten Bewertungen und Empfehlungsgrade zu RT-Indikationen und -Modalitäten berücksichtigen mehrheitlich das von den Radioonkologen Vorgeschlagene. Auf die Änderungen wird im Einzelnen eingegangen.

Abstract

The radiation oncologists involved in the updating process of the S3 guidelines had to identify the need for some refinements regarding primary therapy, treatment of locoregional recurrences and of metastatic disease taking recent data and concepts of radiotherapy (RT) into account. Updates with respect to indications for RT affect target volumes in cases of locoregional lymph node involvement, partial breast irradiation including (sole) intraoperative RT, hypofractionated RT, combinations with systemic treatment and the management of locoregional relapses and distant metastases. In accordance with the methodological specifications of the S3 update procedure, the validity of existing indications for RT were to a large extent revised by adaption to a number of predetermined guidelines. Therefore, the new statements with respect to RT are only partially derived from up to date systematic reviews of databases and original references from the past 2 years. The appraisals and grades of recommendations related to indications and modalities of RT developed in a multidisciplinary and cross-sectional comprehensive consensus incorporate most of the proposals of the radiation oncologists. Amendments are described in detail.

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Authors and Affiliations

  1. Klinik für Radioonkologie, Universitätsklinikum Tübingen, Tübingen, Deutschland

    R. Souchon

  2. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    W. Budach

  3. Klinik für Strahlentherapie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland

    J. Dunst

Authors
  1. R. Souchon
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  2. W. Budach
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  3. J. Dunst
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Correspondence to R. Souchon.

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Souchon, R., Budach, W. & Dunst, J. Strahlentherapie . Gynäkologe 45, 448–452 (2012). https://doi.org/10.1007/s00129-011-2918-0

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  • DOI: https://doi.org/10.1007/s00129-011-2918-0

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