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Intraoperative Strahlentherapie (IORT) beim Mammakarzinom

Helfen wir wirklich den Patientinnen?

Intraoperative radiation therapy (IORT) for breast cancer

Do we really help the patients?

  • Gynäkologie aktuell
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Literatur

  1. Fisher B, Anderson S, Bryant J et al (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation fort he treatment of invasive breast cancer. N Engl J Med 347(16):1233–1241

    Article  PubMed  Google Scholar 

  2. Veronesi U, Cascinelli N, Mariani L et al (2002) Twenty-year follow-up of a randomised study comparing breast-conserving surgery with radical mastektomy for early breast cancer. N Engl J Med 347(16):1227–1232

    Article  PubMed  Google Scholar 

  3. EBCTCG (1995) Effects of radiotherapy and surgery in early breast cancer: An overview of the randomized trials. Early Breast Cancer Trialists Collaborative Group. N Engl J Med 333:1444–1455

    Article  Google Scholar 

  4. Holland R, Veling SH, Mravunac M et al (1985) Histologic multifocality of Tis, T1–2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 56:979–990

    Article  PubMed  CAS  Google Scholar 

  5. Bartelink H, Horiot JC, Poortmans PM et al (2007) Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost vs. no boost EORTC 22881–10882 trial. J Clin Oncol 25(22):3259–3265

    Article  PubMed  Google Scholar 

  6. Dunst J (1995) Adjuvante Strahlentherapie beim operablen Mammakarzinom. Onkologe 1(7):205–213

    Google Scholar 

  7. Clarke M, Collins R, Darby S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366(9503):2087–2106

    PubMed  CAS  Google Scholar 

  8. Sedlmayer F, Fastner G, Merz F et al (2007) ISIORT Europe. IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: results of an ISIORT pooled analysis. Strahlenther Onkol (S) 183:32–34

    Article  Google Scholar 

  9. Wenz F, Welzel G, Blank E et al (2010) Intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage X-rays: the first 5 years of experience with a novel approach. Int J Radiat Oncol Biol Phys 77:1309–1314

    Article  PubMed  Google Scholar 

  10. Vaidya JS, Joseph DJ, Tobias JS et al (2010) Targeted intraoperative radiotherapy versus whole brest radiotherapy for breast cancer (TARGIT-A-trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 376:91–102

    Article  PubMed  Google Scholar 

  11. Veronesi U, Orecchia R, Luini A et al (2010) Intraoperative radiotherapy during breast conserving surgery: a study on 1822 cases treated with electrons. Breast Cancer Res Treat 124:141–151

    Article  PubMed  Google Scholar 

  12. Veronesi U, Marubini E, Mariani L et al (2001) Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol 12(7):997–1003

    Article  PubMed  CAS  Google Scholar 

  13. Wenz F, Budach W, Dunst J et al (2009) Accelerated partial breast irradiation (APBI) ready fpr prime time? Strahlenther Onkol 185:653–655

    Article  PubMed  Google Scholar 

  14. Drago S, Rossi C, Grassi GB (2005) Intraoperative radiation therapy for breast cancer. The role of the surgeon and the surgical perspective. Tumori 4(6):16–19

    Google Scholar 

  15. Vrieling C, Collette L, Fourquet A et al (2000) The influence of patient, tumor and treatment factors on the cosmetic results after breast-conserving therapy in the EORTC boost vs. no boost trial EORTC. Radiother Oncol 55:219–232

    Article  PubMed  CAS  Google Scholar 

  16. Antonini N, Jones H, Horiot JC et al (2007) Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881–10882. Radiother Oncol 82:265–271

    Article  PubMed  Google Scholar 

  17. Sautter-Bihl ML, Sedlmayer F, Budach W et al (2010) Intraoperative Radiotherapy as Accelerated Partial Breast Irradiation for Early Breast Cancer. Strahlenther Onkol 186:651–657

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinikum der Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    K. Zwiefel, S. Mohrmann, A. Schönherr &  W. Janni

Authors
  1. K. Zwiefel
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  2. S. Mohrmann
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  3. A. Schönherr
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  4. W. Janni
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Corresponding author

Correspondence to W. Janni.

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Zwiefel, K., Mohrmann, S., Schönherr, A. et al. Intraoperative Strahlentherapie (IORT) beim Mammakarzinom. Gynäkologe 44, 303–308 (2011). https://doi.org/10.1007/s00129-011-2780-0

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  • DOI: https://doi.org/10.1007/s00129-011-2780-0

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