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Influenzainfektion in der Gravidität

Alles nur Panik?

Influenza during pregnancy

Nothing but panic?

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Der Gynäkologe Aims and scope

Zusammenfassung

Das Erkrankungsrisiko ist bei der pandemischen und saisonalen Influenzavirusinfektion für Schwangere erhöht. Schwangere erkranken im Vergleich zu nichtschwangeren Frauen in jüngerem Alter, die Erkrankung verläuft schwerer, sie müssen häufiger hospitalisiert und intensivmedizinisch behandelt werden. Darüber hinaus sind vermehrt Todesfälle bei Schwangeren zu beklagen. Die neonatale Morbidität und Mortalität ist relevant erhöht, wenn Schwangere an einer Influenzavirusinfektion leiden. Die allgemeine Impfung von Schwangeren gegen Influenza ist eine attraktive Lösung zu Verhinderung der Krankheitslast und Mortalität bei den schwangeren Frauen und deren Kindern.

Abstract

For pregnant women influenza (seasonal and pandemic) may have a more severe clinical course, increased complication rate, and higher case fatality rate. Pregnant women are at younger age when hospitalized. There is an increased risk for adverse outcomes among infants born to mothers infected with influenza during pregnancy. Pregnant women should be considered a high priority for receipt of influenza vaccine with the aim of preventing both the illness and mortality in mother and infant.

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Literatur

  1. Jamieson DJ, Theiler RN, Rasmussen SA (2006) Emerging infections and pregnancy. Emerg Infect Dis 12:1638–1643

    PubMed  Google Scholar 

  2. Gaunt G, Ramin K (2001) Immunological tolerance of the human fetus. Am J Perinatol 18:299–312

    Article  PubMed  CAS  Google Scholar 

  3. Szekeres-Bartho J (2002) Immunological relationship between the mother and the fetus. Int Rev Immunol 21:471–495

    Article  PubMed  CAS  Google Scholar 

  4. Elenkov IJ, Wilder RL, Bakalov VK et al (2001) IL12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab 86:4933–4938

    Article  PubMed  CAS  Google Scholar 

  5. Runmarker B, Anderson O (1995) Pregnancy is associated with a lower risk of onset and a better prognosis in multiple sclerosis. Brain 118:253–261

    Article  PubMed  Google Scholar 

  6. Imrie HJ, McGonigle TP, Liu DT, Jones DR (1996) Reduction in erythrocyte complement receptor 1 (CR1, CD35) and decay accelerating factor (DAF, CD55) during normal pregnancy. J Reprod Immunol 31:221–227

    Article  PubMed  CAS  Google Scholar 

  7. Robert-Koch-Institut (2010) Epidemiologisches Bull Nr. 31

  8. Harris JW (1919) Influenza occurring in pregnant woman; a statistical study of thirteen hundred and fifty cases. JAMA 72:978–980

    Google Scholar 

  9. Freeman DW, Barno A (1959) Deaths from Asian influenza associated with pregnancy. Am J Obstet Gynecol 78:1172–1175

    PubMed  CAS  Google Scholar 

  10. Siston AM, Rasmussen SA, Honein MA et al (2010) Pandemic 2009 influenza A (H1N1) virus illness among pregnant woman in the United States. JAMA 303:1517

    Article  PubMed  CAS  Google Scholar 

  11. Mosby LG, Rasmussen SA, Jamieson DJ (2011) 2009 Pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature. Am J Obstet Gynecol in press

  12. Louie JK, Jean C, Acosta M et al (2011) A review of adult mortality due to 2009 pandemic (H1N1) influenza in California. PLoS One 6:e18221

    Article  PubMed  CAS  Google Scholar 

  13. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL et al (2009) H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet published online July 2009

  14. Neuzil KM, Reed GW, Mitchel EF et al (1998) Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women. Am J Epidemiol 148:1094–1102

    PubMed  CAS  Google Scholar 

  15. Mullooly JP, Barker WH, Nolan TF (1986) Risk of acute respiratory disease among pregnant women during influenza A epidemics. Public Health Rep 101:205–211

    PubMed  CAS  Google Scholar 

  16. Cox S, Posner SF, McPheeters M et al (2006) Hospitalizations with respiratory illness among pregnant women during influenza season. Obstet Gynecol 107:1315–1322

    Article  PubMed  Google Scholar 

  17. Creanga AA, Kamimoto L, Newsome K, D’Mello T et al (2011) Seasonal and 2009 influenza A (H1N1) virus infection during pregnancy. A population-based study of hospitalized cases. Am J Obstet Gynecol in press

  18. Skowronski DM, De Serres G (2009) Is routine influenza immunization warranted in early pregnancy. Vaccine 27(35):4754–4770

    Article  PubMed  Google Scholar 

  19. Schanzer DL, Langley JM, Tam TW (2007) Influenza-attributed hospitalization rates among pregnant women in Canada 1994–2000. J Obst Gynaecol Can 29(8):622–629

    Google Scholar 

  20. http://www.who.int. Global Alert and Response (GAR). Pandemic influenza in pregnant women, 31.07.2009

  21. Tamma PD, Ault KA et al (2009) Safety of influenza vaccination during pregnancy. Am J Obstet Gynecol 201:547–552

    Article  PubMed  CAS  Google Scholar 

  22. Munoz FM, Greisinger AJ, Wehmanen OA et al (2005) Safety of influenza vaccination during pregnancy. Am J Obstet Gynecol 192:1098–1106

    Article  PubMed  Google Scholar 

  23. Steinhoff MC, Omer SB, Roy E et al (2010) Influenza immunization in pregnancy-antibody responses in mothers and infants. N Engl J Med 362:1644–1646

    Article  PubMed  CAS  Google Scholar 

  24. Eick AA, Uyeki TM, Klimov A et al (2011) Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med 165(2):104–111

    Article  PubMed  Google Scholar 

  25. Zaman K, Roy E, Arifeen SE et al (2008) Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med 359:1555–1564

    Article  PubMed  CAS  Google Scholar 

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Interessenkonflikt

Der Autor gibt an, bei klinischen Studien zur Prüfung von Influenzaimpfstoffen im Kindes- und Jugendlichenalter für die Firmen GSK, München, und Novartis, Holzkirchen, als Leiter der klinischen Prüfung bzw. als Prüfarzt tätig zu sein. Er ist beratend für die Firma Astra Zeneca, Wedel im Bereich Influenzaimpfstoffe für Kinder und Jugendliche tätig.

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Correspondence to M. Knuf.

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Knuf, M. Influenzainfektion in der Gravidität. Gynäkologe 44, 593–600 (2011). https://doi.org/10.1007/s00129-011-2775-x

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  • DOI: https://doi.org/10.1007/s00129-011-2775-x

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