Abstract
The present study assessed the residue levels of six parent neonicotinoids (p-NEOs) and four metabolites (m-NEOs) in indoor dust collected from 12 cities of China. Acetamiprid (ACE) and imidacloprid (IMI) were the predominated p-NEOs (detection rates: 98%) with the median values at 4.54 and 7.48 ng/g dry weight (dw), respectively. N-demethyl-acetamiprid (N-dm-ACE) was the most important m-NEO with the median value at 0.69 ng/g dw, while other m-NEOs were rarely detected (detection rates: < 15%). Significant correlation between ACE and thiacloprid (THD) was observed (p < 0.01), indicating their probably concurrent applications. ACE was significantly correlated to N-dm-ACE (p < 0.01), implicating the degradation of ACE in indoor environment. The estimated daily intake (EDIing) of NEOs via dust ingestion were far lower than the acceptable daily intake for NEOs. To our knowledge, this study provided a baseline nationwide investigation on the occurrence of NEOs in indoor dust of China.
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References
Badgujar PC, Jain SK, Singh A, Punia JS, Gupta RP, Chandratre GA (2013) Immunotoxic effects of imidacloprid following 28 days of oral exposure in BALB/c mice. Environ Toxicol Pharmacol 35(3):408–418. https://doi.org/10.1016/j.etap.2013.01.012
Bennett B, Workman T, Smith MN, Griffith WC, Thompson B, Faustman EM (2019) Longitudinal, Seasonal, and Occupational Trends of Multiple Pesticides in House Dust. Environ Health Perspect 127(1):17003. https://doi.org/10.1289/EHP3644
Beranger R et al (2019) Agricultural and domestic pesticides in house dust from different agricultural areas in France. Environ Sci Pollut Res Int 26(19):19632–19645. https://doi.org/10.1007/s11356-019-05313-9
Bhardwaj S, Srivastava MK, Kapoor U, Srivastava LP (2010) A 90 days oral toxicity of imidacloprid in female rats: morphological, biochemical and histopathological evaluations. Food Chem Toxicol 48(5):1185–1190. https://doi.org/10.1016/j.fct.2010.02.009
Casida JE, Durkin KA (2013) Neuroactive insecticides: targets, selectivity, resistance, and secondary effects. Annu Rev Entomol 58:99–117. https://doi.org/10.1146/annurev-ento-120811-153645
Cavallaro MC, Morrissey CA, Headley JV, Peru KM, Liber K (2017) Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam toChironomus dilutusand estimation of toxic equivalency factors. Environ Toxicol Chem 36(2):372–382. https://doi.org/10.1002/etc.3536
Chen Y et al (2019a) Ecological risk assessment of the increasing use of the neonicotinoid insecticides along the east coast of China. Environ Int 127:550–557. https://doi.org/10.1016/j.envint.2019.04.010
Chen Y et al (2019b) Resolution of the Ongoing Challenge of Estimating Nonpoint Source Neonicotinoid Pollution in the Yangtze River Basin Using a Modified Mass Balance Approach. Environ Sci Technol 53(5):2539–2548. https://doi.org/10.1021/acs.est.8b06096
Chen D et al (2020) Dietary exposure to neonicotinoid insecticides and health risks in the Chinese general population through two consecutive total diet studies. Environ Int 135:105399. https://doi.org/10.1016/j.envint.2019.105399
Duan X, Zhao X, Wang B, Chen Y, Cao S (2015) Highlights of the Chinese Exposure Factors Handbook (Adults). Science Press, Beijing. ((In Chinese))
Duan X, Zhao X, Wang B, Chen Y, Cao S (2016) Highlights of the Chinese Exposure Factors Handbook(Children). China Environmental Science Press, Beijing. ((In Chinese))
Eng ML, Stutchbury BJM, Morrissey CA (2017) Imidacloprid and chlorpyrifos insecticides impair migratory ability in a seed-eating songbird. Sci Rep 7(1):15176–15176. https://doi.org/10.1038/s41598-017-15446-x
Fang Q et al (2017) Degradation Dynamics and Dietary Risk Assessments of Two Neonicotinoid Insecticides during Lonicera japonica Planting, Drying, and Tea Brewing Processes. J Agric Food Chem 65(8):1483–1488. https://doi.org/10.1021/acs.jafc.6b04658
FAO (2020) World Food and Agriculture - Statistical Yearbook 2020. FAO, Rome
Gupta S, Gajbhiye VT, Gupta RK (2008) Effect of light on the degradation of two neonicotinoids viz acetamiprid and thiacloprid in soil. Bull Environ Contam Toxicol 81(2):185–189. https://doi.org/10.1007/s00128-008-9405-x
Hallmann CA, Foppen RPB, van Turnhout CAM, de Kroon H, Jongejans E (2014) Declines in insectivorous birds are associated with high neonicotinoid concentrations. Nature 511(7509):341–343. https://doi.org/10.1038/nature13531
Jiang J et al (2018) Concentrations of imidacloprid and thiamethoxam in pollen, nectar and leaves from seed-dressed cotton crops and their potential risk to honeybees (Apis mellifera L.). Chemosphere 201:159–167. https://doi.org/10.1016/j.chemosphere.2018.02.168
Kurwadkar S, Evans A, DeWinne D, White P, Mitchell F (2016) Modeling photodegradation kinetics of three systemic neonicotinoids-dinotefuran, imidacloprid, and thiamethoxam-in aqueous and soil environment. Environ Toxicol Chem 35(7):1718–1726. https://doi.org/10.1002/etc.3335
Layton DW, Beamer PI (2009) Migration of Contaminated Soil and Airborne Particulates to Indoor Dust. Environ Sci Technol 43(21):8199–8205. https://doi.org/10.1021/es9003735
Li Y, Li Y, Liu Y, Ward TJ (2018a) Photodegradation of clothianidin and thiamethoxam in agricultural soils. Environ Sci Pollut Res 25(31):31318–31325. https://doi.org/10.1007/s11356-018-3121-9
Li Y, Su P, Li Y, Wen K, Bi G, Cox M (2018b) Adsorption-desorption and degradation of insecticides clothianidin and thiamethoxam in agricultural soils. Chemosphere 207:708–714. https://doi.org/10.1016/j.chemosphere.2018.05.139
Lu C, Chang CH, Palmer C, Zhao M, Zhang Q (2018) Neonicotinoid Residues in Fruits and Vegetables: An Integrated Dietary Exposure Assessment Approach. Environ Sci Technol 52(5):3175–3184. https://doi.org/10.1021/acs.est.7b05596
Mahai G, Wan Y, Xia W, Yang S, He Z, Xu S (2019) Neonicotinoid insecticides in surface water from the central Yangtze River, China. Chemosphere 229:452–460. https://doi.org/10.1016/j.chemosphere.2019.05.040
Ministry of Agriculture and Rural Affairs, PRC (2015) Pesticide acceptable daily intake. China Agricultural Press, pp 2–9. ((In Chinese))
Rundlöf M et al (2015) Seed coating with a neonicotinoid insecticide negatively affects wild bees. Nature 521(7550):77–80. https://doi.org/10.1038/nature14420
Salis S et al (2017) Occurrence of imidacloprid, carbendazim, and other biocides in Italian house dust: Potential relevance for intakes in children and pets. J Environ Sci Health B 52(9):699–709. https://doi.org/10.1080/03601234.2017.1331675
Sánchez-Bayo F, Belzunces L, Bonmatin J-M (2017) Lethal and sublethal effects, and incomplete clearance of ingested imidacloprid in honey bees (Apis mellifera). Ecotoxicology 26(9):1199–1206. https://doi.org/10.1007/s10646-017-1845-9
Senyildiz M, Kilinc A, Ozden S (2018) Investigation of the genotoxic and cytotoxic effects of widely used neonicotinoid insecticides in HepG2 and SH-SY5Y cells. Toxicol Ind Health 34(6):375–383. https://doi.org/10.1177/0748233718762609
Sheets LP, Li AA, Minnema DJ, Collier RH, Creek MR, Peffer RC (2016) A critical review of neonicotinoid insecticides for developmental neurotoxicity. Crit Rev Toxicol 46(2):153–190. https://doi.org/10.3109/10408444.2015.1090948
Shin HM, Moschet C, Young TM, Bennett DH (2020) Measured concentrations of consumer product chemicals in California house dust: Implications for sources, exposure, and toxicity potential. Indoor Air 30(1):60–75. https://doi.org/10.1111/ina.12607
Simon-Delso N et al (2015) Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites. Environ Sci Pollut Res 22(1):5–34. https://doi.org/10.1007/s11356-014-3470-y
Sparks TC et al (2020) Insecticides, biologics and nematicides: Updates to IRAC’s mode of action classification - a tool for resistance management. Pestic Biochem Physiol 167:104587. https://doi.org/10.1016/j.pestbp.2020.104587
Tang T, Cui W, Wei D, Shuqing Y, Zhengbiao L, Quan Z (2019) An integrated assessment and spatial-temporal variation analysis of neonicotinoids in pollen and honey from noncrop plants in Zhejiang, China. Environ Pollut 250:397–406. https://doi.org/10.1016/j.envpol.2019.04.004
Tomizawa M (2004) Neonicotinoids and Derivatives: Effects in Mammalian Cells and Mice. J Pestic Sci 29:177–183. https://doi.org/10.1584/jpestics.29.177
Vohra P, Khera KS, Sangha GK (2014) Physiological, biochemical and histological alterations induced by administration of imidacloprid in female albino rats. Pestic Biochem Physiol 110:50–56. https://doi.org/10.1016/j.pestbp.2014.02.007
Wang A et al (2019) Neonicotinoids and carbendazim in indoor dust from three cities in China: Spatial and temporal variations. Sci Total Environ 695:133790. https://doi.org/10.1016/j.scitotenv.2019.133790
Zhang M, Zhao P, Yan Q, Li X (2012) The Market and Environmental Impact of the Neonicotinoid Insecticides. Agrochemicals 51(12):859–862. https://doi.org/10.16820/j.cnki.1006-0413.2012.12.001((In Chinese))
Zhang P, Sun H, Ren C, Min L, Zhang H (2018) Sorption mechanisms of neonicotinoids on biochars and the impact of deashing treatments on biochar structure and neonicotinoids sorption. Environ Pollut 234:812–820. https://doi.org/10.1016/j.envpol.2017.12.013
Zhang T et al (2019) A nationwide survey of urinary concentrations of neonicotinoid insecticides in China. Environ Int 132:105114. https://doi.org/10.1016/j.envint.2019.105114
Zhang C et al (2020) Contamination of neonicotinoid insecticides in soil-water-sediment systems of the urban and rural areas in a rapidly developing region: Guangzhou, South China. Environ Int 139:105719. https://doi.org/10.1016/j.envint.2020.105719
Zhang H et al (2021a) Occurrence and distribution of neonicotinoids and characteristic metabolites in paired urine and indoor dust from young adults: Implications for human exposure. Environ Res 199:111175. https://doi.org/10.1016/j.envres.2021.111175
Zhang N et al (2021b) Occurrence of neonicotinoid insecticides and their metabolites in tooth samples collected from south China: Associations with periodontitis. Chemosphere 264(Pt 1):128498. https://doi.org/10.1016/j.chemosphere.2020.128498
Zhao Q et al (2022) Global climate change and human health: Pathways and possible solutions. Eco-Environment & Health 1:53. https://doi.org/10.1016/j.eehl.2022.04.004
Zhou Y et al (2018) Development of a fast and sensitive method for measuring multiple neonicotinoid insecticide residues in soil and the application in parks and residential areas. Anal Chim Acta 1016:19–28. https://doi.org/10.1016/j.aca.2018.02.047
Zhou Y et al (2020) Levels and inhalation health risk of neonicotinoid insecticides in fine particulate matter (PM2.5) in urban and rural areas of China. Environ Int 142:105822. https://doi.org/10.1016/j.envint.2020.105822
Acknowledgements
The authors wish to acknowledge the Natural Science Foundation of China (22022612, 41877375, and 22036004) and Natural Science Foundation of Guangdong Province, China (No. 2020A0104006, No. 2021A1515010243 and No. 2016A030306033) for their partial research support.
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Huang, Y., Zhang, B., Xue, J. et al. A Pilot Nationwide Survey on the Concentrations of Neonicotinoids and Their Metabolites in Indoor Dust from China: Application for Human Exposure. Bull Environ Contam Toxicol 109, 900–909 (2022). https://doi.org/10.1007/s00128-022-03600-9
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DOI: https://doi.org/10.1007/s00128-022-03600-9