Abstract
The influence of fluctuating water temperature and dietary oxytetracycline (OTC) at 0 (0X), 80 (1X), 240 (3X), 400 (5X) and 800 mg (10X)/kg biomass/day for 30 consecutive days on the safety of monosex (all male) Nile tilapia Oreochromis niloticus fries in terms of feeding, growth, survival and histopathology of vital organs were assessed. A dose-dependent decline in feed intake and biomass was recorded. The OTC-dosed groups recorded higher mortalities than the control. The therapeutic OTC-dosing (1X) in conjunction with low temperature caused 75.56 ± 8.01% mortality and 25.75% reduced feed intake in 30 days. The mortalities increased with increasing OTC-doses from 85.19 ± 3.39% (1X) to 95.56 ± 2.22% (10X) and fluctuating temperature (12.00–21.50°C) even after the withdrawal of OTC. Relatively mild to moderate histopathological lesions were observed in the kidney, liver and intestine of OTC-dosed fries. These results suggested that dietary OTC and low water temperature may cause adverse effects on monosex O. niloticus fries.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ambili TR, Saravanan M, Ramesh M, Abhijith DB, Poopal RK (2013) Toxicological effects of the antibiotic oxytetracycline to an Indian major carp Labeo rohita. Arch Environ Contam Toxicol 64(3):494–503. https://doi.org/10.1007/s00244-012-9836-6
Bowker JD, Carty D, Bowman MP (2013) The safety of SLICE (0.2% Emamectin Benzoate) administered in feed to fingerling rainbow trout. N Am J Aquacult 75(4):455–462. https://doi.org/10.1080/15222055.2013.806383
Charo-Karisa H, Rezk MA, Bovenhuis H, Komen H (2005) Heritability of cold tolerance in Nile tilapia, Oreochromis niloticus, juveniles. Aquaculture 249:115–123. https://doi.org/10.1016/j.aquaculture.2005.04.029
El-Nahhal Y, EL-dahdouh N, Hamdona N, Alshanti A (2016) Toxicological data of some antibiotics and pesticides to fish, mosquitoes, cyanobacterial mats and to plants. Data Brief 6:871–880. https://doi.org/10.1016/j.dib.2016.01.051
El-Sayed A-FM (2006) Tilapia culture. CABI Publishing, Wallingford, p 304
FAO (2020) The state of world fisheries and aquaculture 2020. Sustainability in action, Rome. https://doi.org/10.4060/ca9229en
Gaikowski MP, Wolf JC, Schleis SM, Gingerich WH (2003) Safety of oxytetracycline (Terramycin TM-100F) administered in feed to hybrid striped bass, walleyes, and yellow perch. J Aquat Anim Health 15(4):274–286. https://doi.org/10.1577/H03-042.1
Grondel JL, Nouws JFM, van Muiswinkel WW (1987) The influence of antibiotics on the immune system: immune pharmacokinetic investigations on the primary anti-SRBC response in carp, Cyprinus carpio L. after oxytetracycline injection. J Fish Dis 10:35–43. https://doi.org/10.1111/j.1365-2761.1987.tb00716.x
Julinta RB, Abraham TJ, Roy A, Singha J, Boda S, Patil PK (2019a) Dietary influences of oxytetracycline on the growth and serum biomarkers of Oreochromis niloticus (L.). Ecotox Environ Safe 186: https://doi.org/10.1016/j.ecoenv.2019.109752
Julinta RB, Abraham TJ, Roy A et al (2019b) Effect of oxytetracycline-dosing on the growth, safety and intestinal histology of Nile tilapia, Oreochromis niloticus (L.) juveniles. Int J Curr Microbiol App Sci 8(8):2708–2724. https://doi.org/10.20546/ijcmas.2019.808.313
Lawal MO, Aderolu AZ, Ezenwanne DO (2012) The growth rate and histology of catfish (Clarias gariepinus) juveniles fed antibiotics (Oxytetracycline and Furasol) treated feed. Rep Opin 4:37–42
Limbu SM, Chen L-Q, Zhang M-L, Du Z-Y (2020) A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review. Rev Aquacult. https://doi.org/10.1111/raq.12511
Marking LL, Howe GE, Crowther JR (1988) Toxicity of erythromycin, oxytetracycline, and tetracycline administered to lake trout in water baths, by injection, or by feeding. Prog Fish-Cult 50(4):197–201
Reda RM, Ibrahim RE, Ahmed ENG, El-Bouhy ZM (2013) Effect of oxytetracycline and florfenicol as growth promoters on the health status of cultured Oreochromis niloticus. Egypt J Aquat Res 39:241–248. https://doi.org/10.1016/j.ejar.2013.12.001
Roberts RJ (2012) Fish pathology, 4th edn. Wiley-Blackwell, Oxford, p 581
Rodrigues S, Antunes SC, Nunes B, Correia AT (2019) Histopathological effects in gills and liver of Sparus aurata following acute and chronic exposures to erythromycin and oxytetracycline. Environ Sci Pollut Res Int 26(15):15481–15495. https://doi.org/10.1007/s11356-019-04954-0
Roy A, Abraham TJ, Namdeo MS, Singha J, Julinta RB, Boda S (2019) Effects of oral oxytetracycline-therapy on wound progression and healing following Aeromonas caviae infection in Nile tilapia (Oreochromis niloticus L.). Braz Arch Biol Technol 62: https://doi.org/10.1590/1678-4324-2019180766
Sanchez-Martinez JG, Pérez-Castañeda R, Rábago-Castro JL, Aguirre-Guzmána G, Vázquez-Sauceda ML (2008) A preliminary study on the effects on growth, condition, and feeding indexes in channel catfish, Ictalurus punctatus, after the prophylactic use of potassium permanganate and oxytetracycline. J World Aquacult Soc 39(5):664–670. https://doi.org/10.1111/j.1749-7345.2008.00195.x
Sharma SRK, Sumithra TG, Gangadharan S et al (2021) Evaluation of biosafety and tissue residue of oxytetracycline in juvenile snubnose pompano, Trachinotus blochii along with in vitro efficacy against fish pathogens. Aquaculture 533: https://doi.org/10.1016/j.aquaculture.2020.736184
Svobodová Z, Sudová E, Nepejchalová L et al (2006) Effects of oxytetracycline containing feed on pond ecosystem and health of carp (Cyprinus carpio L.). Acta Vet Brno 75:571–577. https://doi.org/10.2754/avb200675040571
Teichert-Coddington DR, Popm TJ, Lovshin LL (1997) Attributes of tropical pond-cultured fish. In: Egna HS, Boyd CE (eds) Dynamics of pond aquaculture. CRC Press, Boca Raton, pp 183–198
Toften H, Jobling M (1996) Development of spinal deformities in Atlantic salmon and Arctic charr fed diets supplemented with oxytetracycline. J Fish Biol 49:668–677. https://doi.org/10.1111/j.1095-8649.1996.tb00063.x
Toften H, Jobling M (1997) Feed intake and growth of Atlantic salmon, Salmo salar L. fed diets supplemented with oxytetracycline and squid extract. Aquacult Nutr 3:145–151. https://doi.org/10.1046/j.1365-2095.1997.00081.x
Trushenski JT, Aardsma MP, Barry KJ et al (2018) Oxytetracycline does not cause growth promotion in finfish. J Anim Sci J 96(5):1667–1677. https://doi.org/10.1093/jas/sky120
USFWS (2015) Approved drugs for use in aquaculture. 2nd edn. U.S. Fish and Wildlife Service’s Aquatic Animal Drug Approval Partnership Program, American Fisheries Society’s Fish Culture and Fish Health Sections, Association of Fish and Wildlife Agencies, and Fisheries and Water Resources Policy Committee’s Drug Approval Working Group. https://southcenters.osu.edu/sites/southc/files/site-library/site-documents/aquaext/approved_drugs_aquaculture.pdf
Van der Oost R, Beyer J, Vermeulen NPE (2003) Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ Toxicol Pharmacol 13(2):57–149. https://doi.org/10.1016/S1382-6689(02)00126-6
Watts JEM, Schreier HJ, Lanska L, Hale MS (2017) The rising tide of antimicrobial resistance in aquaculture: sources, sinks and solutions. Mar Drugs 15(6):158. https://doi.org/10.3390/md15060158
Acknowledgements
The work was supported by the Indian Council of Agricultural Research, Government of India, New Delhi, India under the All India Network Project on Fish Health (Grant F. No. CIBA/AINP-FH/2015-16 dated June 02, 2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that there are no conflicts of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Roy, A., Abraham, T.J., Julinta, R.B. et al. Influence of Fluctuating Water Temperature and Dietary Oxytetracycline on the Safety of Monosex Nile Tilapia Oreochromis niloticus Fries. Bull Environ Contam Toxicol 107, 361–369 (2021). https://doi.org/10.1007/s00128-021-03227-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00128-021-03227-2