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Associations of Dietary Exposure to Organochlorine Pesticides from Plant-Origin Foods with Lipid Metabolism and Inflammation in Women: A Multiple Follow-up Study in North China

Abstract

This study explored effects of dietary OCP intake from plant-origin foods (cereals, fruits, and vegetables) consumption on lipid metabolism and inflammation of women using a multiple follow-up study. The results showed that dietary intake of p,p′-dichlorodiphenyltrichloroethane (DDT) [β = − 10.11, 95% confidence interval (95%CI): − 17.32, − 2.905] and o,p′-dichlorodiphenyldichloroethylene (DDE) (β = − 6.077, 95%CI: − 9.954, − 2.200) were overall negatively associated with serum high-density lipoprotein cholesterol (HDL), whereas other OCPs were not. Serum interleukin (IL)-8 was positively associated with intake of dieldrin (β = 0.390, 95%CI: 0.105, 0.674), endosulfan-β (β = 0.361, 95%CI: 0.198, 0.523), total endosulfan (β = 0.136, 95%CI: 0.037, 0.234), and total OCPs (β = 0.084, 95%CI: 0.016, 0.153), and negatively correlated with intake of p,p′-DDE (β = − 2.692, 95%CI: − 5.185, − 0.198). We concluded that dietary intake of some individual DDT-, DDE- dieldrin-, and endosulfan-class chemicals from plant-origin foods may interfere with lipid metabolism and inflammation responses.

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Acknowledgments

All authors would like to express our gratitude to the help from the working group of environmental exposure and human health of the China Cohort Consortium (See http://chinacohort.bjmu.edu.cn/). This work was supported by the National Natural Science Foundation of China (Grant Nos. 41401583, 41771527, and 41922057).

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Correspondence to Bin Wang or Yanxin Yu.

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Wang, X., Gao, M., Tan, Y. et al. Associations of Dietary Exposure to Organochlorine Pesticides from Plant-Origin Foods with Lipid Metabolism and Inflammation in Women: A Multiple Follow-up Study in North China. Bull Environ Contam Toxicol 107, 289–295 (2021). https://doi.org/10.1007/s00128-021-03224-5

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Keywords

  • OCPs
  • Dietary exposure
  • Lipid metabolism
  • Inflammation