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Methyl Paraben and Carbamazepine in Water and Striped Catfish (Pseudoplatystoma magdaleniatum) in the Cauca and Magdalena Rivers

Abstract

Between 2017 and 2019, samplings were carried out in the San Jorge, Cauca and Magdalena River basins in Colombia, to determine the presence of methyl paraben and carbamazepine in water and Pseudoplatystoma magdaleniatum. For the analysis of the samples, a validation of the analytical method was performed, following the EPA method 1694 (Pharmaceutical and personal care products in water), with slight modifications. This was done by liquid-chromatography tandem mass spectrometry, for quantification of methyl paraben and carbamazepine, including parameters of linearity, accuracy precision and veracity. Carbamazepine was found in the Magdalena River at 8.03 ± 0.01 µg/L in transition season. In fish samples, methyl paraben and carbamazepine were detected in a range between 32 and 90.80 µg/kg in transition and dry seasons.

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References

  • Aceña J, Pérez S, Eichhorn P, Solé M, Barceló D (2017) Metabolite profiling of carbamazepine and ibuprofen in solea senegalensis bile using high-resolution mass spectrometry. Anal Bioanal Chem 409(23):5441–5450

    Google Scholar 

  • Alslev B, Korsgaard B, Bjerregaard P (2005) Estrogenicity of butylparaben in rainbow trout oncorhynchus mykiss exposed via food and water. Aquatic Toxicol 72(4):295–304

    CAS  Google Scholar 

  • Alvarez S, Jessick AM, Palacio JA, Kolok AS (2012) Methylmercury concentrations in six fish species from two colombian rivers. Bull Environ Contam Toxicol 88(1):65–68

    CAS  Google Scholar 

  • Artacho-Cordón F, Arrebola JP, Nielsen O, Hernández P, Skakkebaek NE, Fernández MF, Frederiksen H (2017) Assumed non-persistent environmental chemicals in human adipose tissue; matrix stability and correlation with levels measured in urine and serum. Environ Res 156:120–127

    Google Scholar 

  • Arukwe A, Goksøyr A (2003) Eggshell and egg yolk proteins in fish: oepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption. Comp Hepatol 2:4

    Google Scholar 

  • Atencio-García VJ (2000) Impactos de la hidroeléctrica Urrá en los peces migratorios del río Sinú. Revista Temas Agrarios 5(9):29–40

    Google Scholar 

  • Bahlmann A, Carvalho JJ, Weller MG, Panne U, Schneider RJ (2012) Immunoassays as high-throughput tools: monitoring spatial and temporal variations of carbamazepine, caffeine and cetirizine in surface and wastewaters. Chemosphere 89(11):1278–1286

    CAS  Google Scholar 

  • Boberg J, Taxvig C, Christiansen S, Hass U (2010) Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol 30(2):301–312

    CAS  Google Scholar 

  • Calafat AM, Ye X, Wong L-Y, Bishop AM, Needham LL (2010) Urinary concentrations of four parabens in the U.S. population: 2005-2006. Environ Health Perspect 118:679–685

  • Chiesa LM, Pavlovic R, Panseri S, Arioli F (2018) Evaluation of parabens and their metabolites in fish and fish products: a comprehensive analytical approach using LC-HRMS. Food Addit Contam Part A 35(12):2400–2413

    CAS  Google Scholar 

  • Commission Regulation (EU) No 358/2014 of 9 April 2014 amending Annexes II and V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products

  • Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, Pope GS (2004) Concentrations of parabens in human breast tumours. J Appl Toxicol 24(1):5–13

    CAS  Google Scholar 

  • Dietrich S, Ploessl F, Bracher F, Laforsch C (2010) Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in daphnia magna—a multigenerational study. Chemosphere 79(1):60–66

    CAS  Google Scholar 

  • dos Santos MM, Brehm FA, Filippe TC, Knapik HG, de Azevedo JCR (2016) Occurrence and risk assessment of parabens and triclosan in surface waters of southern brazil: a problem of emerging compounds in an emerging country. Rev Bras Recur Hidr 21(3):603–617

    Google Scholar 

  • EPA US (2007) EPA Method: 1694, Pharmaceuticals and personal care products in water, soil, sediment and biosolids by HPLC/ M/M. EPA-821-R-08-002

  • Flores-Navas A, Brown A (2010) Peces Nativos de Agua Dulce de América del Sur de interés para la Acuicultura: Una Síntesis del Estado de Desarrollo Tecnológico de su Cultivo. Serie Acuicultura en Latinoamérica. FAO. Número 1, p 189

  • Gallo H, Díaz J (2003) Variabilidad Genética del Bagre Rayado Pseudoplatystoma fasciatum (Pisces: Pimelodidae) en el Río Magdalena (Colombia). Revista de la academia Colombiana 27(105):599–605

    Google Scholar 

  • Galvis G, Mojica JI (2007) The magdalena river fresh water fishes and fisheries. Aquatic Ecosyst Health Manag 10(2):127–139

    Google Scholar 

  • Golden R, Gandy J, Vollmer G (2005) A review of the endocrine activity of parabens and implications for potential risks to human health. Crit Rev Toxicol 35(5):435–458

    CAS  Google Scholar 

  • González SÁR, Mendoza J, Arocha F, Márquez A (2010) Age and growth of the striped catfish Pseudoplatystoma orinocoense of the average orinoco in venezuela. Zootec Trop 28(2):283–293

    Google Scholar 

  • González MJ, Landines MA, Borbón J, Correal ML, Sánchez C, Rodríguez L (2014) Evaluación de algunos marcadores de exposición a contaminantes en tres especies de bagres colombianos (Pisces: Siluriformes). Biota Colombiana 15(2):40–51

    Google Scholar 

  • Guarnizo M (2007) Caracterización seminal y ensayos preliminares de crioconservación de semen de bagre rayado (Pseudoplatystoma fasciatum-Linnaeus 1766). Disertación tesis de pregrado, Universidad Nacional de Colombia, Facultad de ciencias agropecuarias, Departamento de producción animal, Palmira, Colombia

  • Huerta B, Rodriguez-Mozaz S, Lazorchak J, Barcelo D, Batt A, Wathen J, Stahl L (2018) Presence of pharmaceuticals in fish collected from urban rivers in the U.S. EPA 2008–2009 national rivers and streams assessment. Sci Total Environ 634:542–549

    CAS  Google Scholar 

  • Jiménez-Segura L, Palacio J, López R (2009) Características biológicas del Blanquillo Sorubim cuspicaudus Littmann, Burr y Nass, 2000 y Bagre Rayado Pseudoplatystoma magdaleniatum. Buitrago-Suárez y Burr 2007. (Siluriformes: Pimelodidae) relacionadas con su reproducción en la cuenca media del río Magdalena. Colombia Actualidades Biológicas 31(90):53–66

    Google Scholar 

  • Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008) Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. J Am Med Assoc 300(11):1303–1310

    CAS  Google Scholar 

  • Larsson K, Ljung Björklund K, Palm B, Wennberg M, Kaj L, Lindh CH, Berglund M (2014) Exposure determinants of phthalates, parabens, bisphenol A and triclosan in swedish mothers and their children. Environ Int 73:323–333

    CAS  Google Scholar 

  • Mancera-Rodríguez NJ, Álvarez-León R (2003) Estado del conocimiento de las concentraciones de metales pesados en los peces dulceacuícolas de Colombia. Simposio llevado a cabo en el VIII simposio Colombiano en Ictiología. Montería, Colombia

  • Mancera-Rodríguez NJ, Álvarez-León R (2006) Current state of knowledge of the concentration of mercury and other heavy metals in fresh water fish in Colombia. Acta Biológica Colombiana 11(1):3–23

    Google Scholar 

  • Mojica J, Castellanos C, Usma S, Álvarez R (2002) Libro rojo de peces dulceacuícolas de Colombia. Conservación Internacional. Colombia. Instituto de Ciencias Naturales de la Universidad Nacional de Colombia, Ministerio del Medio Ambiente, Bogotá, Colombia

    Google Scholar 

  • Mojica JI, Valderrama M, Barreto C (2012) Pseudoplatystoma magdaleniatum. En: Mojica JJ, Usma JS, Álvarez-León R, Lasso CA (Eds) Libro rojo de peces dulceacuícolas de Colombia 2012. Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Instituto de Ciencias Naturales de la Universidad Nacional de Colombia, WWF Colombia y Universidad de Manizales. Bogotá, Colombia, pp 230–257

  • Mojica J, Valderrama M, Jiménez-Segura L, Alonso J (2016) Pseudoplatystoma magdaleniatum The IUCN Red List of Threatened Species 2016. https://doi.org/10.2305/IUCN.UK.20161.RLTS.T58439165A61474168.en. Accessed 26 March 2020

  • Olivero-Verbel J, Caballero-Gallardo K, Turizo-Tapia A (2015) Mercury in the gold mining district of san martin de loba, south of bolivar (Colombia). Environ Sci Pollut 22(8):5895–5907

    CAS  Google Scholar 

  • Peña GA (2003) Estudio Arqueo-ictiológico del fenómeno de la subienda en la zona de raudales del río Magdalena. Maguaré 17:307–311

    Google Scholar 

  • Puckowski A, Mioduszewska K, Łukaszewicz P, Borecka M, Caban M, Maszkowska J, Stepnowski P (2016) Bioaccumulation and analytics of pharmaceutical residues in the environment: a review. J Pharm Biomed Anal 127:232–255

    CAS  Google Scholar 

  • Ramakrishnan L, Desaer C (2011) Carbamazepine inhibits distinct chemoconvulsant-induced seizure-like activity in dugesia tigrina. Pharmacol Biochem Behav 99(4):665–670

    CAS  Google Scholar 

  • Ramaswamy BR, Kim J, Isobe T, Chang K, Amano A, Miller TW, Tanabe S (2011) Determination of preservative and antimicrobial compounds in fish from manila bay, philippines using ultra high-performance liquid chromatography tandem mass spectrometry, and assessment of human dietary exposure. J Hazard Mater 192(3):1739–1745

    CAS  Google Scholar 

  • Ramesh F, Nagarajan K (2013) Evaluation of DNA damage of the fish Clarias batrachus exposed to Sago effluent using comet assay. Eur Int J Sci Technol 2(3):12–16

    Google Scholar 

  • Rogawski MA (2006) Molecular targets versus models for new antiepileptic drug discovery. Epilepsy Res 68(1):22–28

    Google Scholar 

  • Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W (2001) In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect 109(3):239–244

    CAS  Google Scholar 

  • Scheytt T, Mersmann P, Lindstädt R, Heberer T (2005) 1-Octanol/water partition coefficients of 5 pharmaceuticals from human medical care: carbamazepine, clofibric acid, diclofenac, ibuprofen, and propyphenazone. Water Air Soil Pollut 165(1–4):3–11

    CAS  Google Scholar 

  • Souza TS, Fontanetti CS (2012) DNA damage of erythrocytes of fish Oreochromis niloticus (Perciformes, Cichlidae), after acute exposure to river water receiving affluent from an oil refinery. J Braz Soc Ecotoxicol 7(2):17–22

    Google Scholar 

  • Valdés ME, Huerta B, Wunderlin DA, Bistoni MA, Barceló D, Rodriguez-Mozaz S (2016) Bioaccumulation and bioconcentration of carbamazepine and other pharmaceuticals in fish under field and controlled laboratory experiments. Evidences of carbamazepine metabolization by fish. Sci Total Environ 557–558:58–67

    Google Scholar 

  • Varga M, ELAbadsa M, Tatár E, Mihucz VG (2019) Removal of selected pharmaceuticals from aqueous matrices with activated carbon under batch conditions. Microchem J 148:661–672

    CAS  Google Scholar 

  • Veldhoen N, Skirrow RC, Brown LLY, Van Aggelen G, Helbing CC (2014) Effects of acute exposure to the non-steroidal anti-inflammatory drug ibuprofen on the developing north american bullfrog (rana catesbeiana) tadpole. Environ Sci Technol 48(17):10439–10447

    CAS  Google Scholar 

  • Wang L, Asimakopoulos AG, Kannan K (2015) Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue. Environ Int 78:45–50

    CAS  Google Scholar 

  • Wu Y, Sun Q, Wang Y, Deng C, Yu C (2017) Comparative studies of aerobic and anaerobic biodegradation of methylparaben and propylparaben in activated sludge. Ecotoxicol Environ Saf 138:25–31

    CAS  Google Scholar 

  • Xue J, Kannan K (2016) Accumulation profiles of parabens and their metabolites in fish, black bear, and birds, including bald eagles and albatrosses. Environ Int 94:546–553

    CAS  Google Scholar 

  • Xue X, Xue J, Liu W, Adams DH, Kannan K (2017) Trophic magnification of parabens and their metabolites in a subtropical marine food web. Environ Sci Technol 51(2):780–789

    CAS  Google Scholar 

  • Yazdanbakhsh A, Nemati R, Massoudinejad M, Jafari M, Dashtdar M (2019) Solar photodegradation of carbamazepine from aqueous solutions using a compound parabolic concentrator equipped with a sun tracking system. Open Chem 17(1):477–484

    CAS  Google Scholar 

  • Zúñiga-Benítez H, Muñoz-Calderón A, Peñuela GA (2018) Removal of a mix of benzophenones and parabens using solar photo-fenton and a cylinder parabolic collector in aqueous solutions. J Environ Chem Eng 6(6):7347–7357

    Google Scholar 

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Acknowledgements

We thank Colciencias for financing the project (call 659-2014) and the GDCON Group of the University of Antioquia. We also thank the University of Antioquia for the approval of the experimental phase in Act 99 of September 29, 2015 by the Ethics Committee for animal testing at the University of Antioquia.

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Correspondence to Sylvia M. Cacua-Ortiz.

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Cacua-Ortiz, S.M., Aguirre, N.J. & Peñuela, G.A. Methyl Paraben and Carbamazepine in Water and Striped Catfish (Pseudoplatystoma magdaleniatum) in the Cauca and Magdalena Rivers. Bull Environ Contam Toxicol 105, 819–826 (2020). https://doi.org/10.1007/s00128-020-03028-z

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Keywords

  • Bioaccumulation
  • Carbamazepine
  • Methyl paraben
  • Striped catfish