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Toxicity and Genotoxicity of Three Antimicrobials Commonly Used in Veterinary Medicine

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Abstract

The toxicity of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) was tested on two green algal species: the international standard Pseudokirchneriella subcapitata and the native Argentine species Ankistrodesmus fusiformis. All three antibiotics inhibited the algal growth. The most sensitive species was P. subcapitata, for which the EC50 for CTC, OTC and ENF were 1.19 ± 0.53, 0.92 ± 0.30 and 5.18 ± 3.80 mg L−1, respectively. The EC50 for A. fusiformis, were 3.23 ± 0.53, 7.15 ± 2.69 and 10.6 ± 1.28 mg L−1, respectively. The genotoxicity of these veterinary antibiotics was also assessed using chromosome aberration (CA) and micronuclei (MN) induction in Allium cepa roots. Three concentrations were tested (0.1, 1 and 10 mg L−1). Only ENF at 1 and 10 mg L−1 showed any significant MN induction. These data revealed that CTC, OTC and ENF could cause toxicity on green algae, whereas ENF could cause genotoxicity on A. cepa plants.

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Acknowledgements

This study was financially supported by the Buenos Aires University, Argentina, under the Project UBACyT No. 20020150200116BA.

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  1. Salud Pública e Higiene Ambiental, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 4° Piso, C1113AAC, Ciudad Autónoma de Buenos Aires, Argentina

    Anahí Magdaleno, Sofía Carusso & Juan Moretton

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  1. Anahí Magdaleno
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  2. Sofía Carusso
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  3. Juan Moretton
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Correspondence to Anahí Magdaleno.

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Magdaleno, A., Carusso, S. & Moretton, J. Toxicity and Genotoxicity of Three Antimicrobials Commonly Used in Veterinary Medicine. Bull Environ Contam Toxicol 99, 315–320 (2017). https://doi.org/10.1007/s00128-017-2091-9

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  • DOI: https://doi.org/10.1007/s00128-017-2091-9

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