Abstract
Eight PBDE congeners, BDE-28, 47, 99, 100, 153, 154, 183 and 209, were measured using gas chromatography coupled to mass spectrometry. The concentrations of Σ8PBDEs ranged from 0.04 to 19.93 ng g−1 lipid weight (lw), with median and mean value of 1.21 and 2.72 ng g−1 lw. PBDE congeners were detected in approximately 90 % of samples with BDE-209 as the dominant one. No significant correlations were found between the mothers’ age, body mass index and PBDEs concentrations. We estimated the infant’s dietary intake of the studied PBDEs via human milk during different nursing durations, and found that babies younger than 1 month might take a relatively higher body burden of PBDEs. The median levels of Σ8PBDEs were 0.74, 2.80, 2.43 and 0.90 ng g−1 lw in colostrum, milk sampled at 1, 3 and 6 months after birth, respectively. High consumption of animal-origin food after birth may lead to the elevated ΣPBDEs concentrations in breast milk. A rational nutrition deployment is essential for postpartum mother.


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Abdallah MAE, Harrad S (2014) Polybrominated diphenyl ethers in UK human milk: implications for infant exposure and relationship to external exposure. Environ Int 63:130–136
Bi XH, Qu WY, Sheng GY, Zhang WB, Mai BX, Chen DJ, Yu L, Fu JM (2006) Polybrominated diphenyl ethers in South China maternal and fetal blood and breast milk. Environ Pollut 144:1024–1030
BSEF (2010) Bromine science an environmental forum. http://www.bsef.org
Chao HA, Chen SC-C, Chang CM, Koh TW, Chang-Chien GP, Ouyang E, Lin SL, Shy CG, Chen FA, Chao HR (2010) Concentrations of polybrominated diphenyl ethers in breast milk correlated to maternal age, education level, and occupational exposure. J Hazard Mater 175:492–500
Cui C, Tian Y, Zhang L, Gao Y, Jin J, Wang P, Ding WW, Wang XJ, Shi R, Wang Y (2012) Polybrominated diphenyl ethers exposure in breast milk in Shanghai, China: levels, influencing factors and potential health risk for infants. Sci Total Environ 433:331–335
Lee S, Kim S, Kim E, Lee IS, Choi G, Kim HJ, Park J, Lj J, Choi K, Moon HB (2013) Polybrominated diphenyl ethers (PBDEs) in breast milk of Korea in 2011: current contamination, time course variation, influencing factors and health risks. Environ Res 126:76–83
Li JG, Yu HF, Zhao YF, Zhang G, Wu YN (2008) levels of polybrominated diphenyl ethers (PBDEs) in breast milk from Beijing, China. Chemosphere 73:182–186
Lignell S, Aune M, Darnerud PO, Hanberg A, Larsson SC, Glynn A (2013) Prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) may influence birth weight among infants in a Swedish cohort with background exposure: a cross-sectional study. Environ Health 12(1):829–834
Liu YP, Dai P, Li JG, Zhang L, Zhao YF, Wu YN, Zhu LY (2008) Fast determination of polybrominated diphenyl ethers in human milk using gas chromatography–negative chemical ionization–mass spectrometry. Chin J Chromatogr 26:687–691
Liu YP, Li JG, Zhao YF, Wen S, Huang FF, Wu YN (2011) Polybrominated diphenyl ethers (PBDEs) and indicator polychlorinated biphenyls (PCBs) in marine fish from four areas of China. Chemosphere 83:168–174
Ma ST, Yu ZQ, Zhang XL, Ren GF, Peng PA, Sheng GY, Fu JM (2012) Levels and congener profiles of polybrominated diphenyl ethers (PBDEs) in breast milk from Shanghai: Implication for exposure route of higher brominated BDEs. Environ Int 42:72–77
Moon HB, Lee DH, Lee YS, Choi M, Choi HG, Kannan K (2012) Polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in adipose tissues of Korean women. Arch Environ Contam Toxicol 62:176–184
Schecter A, Pavuk M, Papke O, Ryan JJ, Birnbaum L, Rosen R (2003) Polybrominated diphenyl ethers (PBDEs) in U.S. mothers’ milk. Environ Health Perspect 111:1723–1729
Shaw SD, Blum A, Weber R, Kannan K, Rich D, Lucas D, Koshland CP, Dobraca D, Hanson S, Hanson S (2010) Halogenated flame retardants: do the fire safety benefits justify the risks? Rev Environ Health 25:261–305
Shen HT, Ding GQ, Wu YN, Pan GS, Zhou XP, Han JL, Li JG, Sheng Wen (2012) Polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) in breast milk from Zhejiang, China. Environ Int 42:84–90
Shi ZX, Yang J, Yue H, Sun ZW, Zhou XQ, Feng JF, Li JG, Wu YN (2013) Levels of tetrabromobisphenol A, hexabromocyclododecanes and polybrominated diphenyl ethers in human milk from the general population in Beijing, China. Sci Total Environ 452–453:10–18
Siddique S, Xian Q, Abdelouahab N, Takser L, Phillips SP, Feng YL, Wang B, Zhu JP et al (2012) Levels of dechlorane plus and polybrominated diphenylethers in human milk in two Canadian cities. Environ Int 39:50–55
Sjodin A, Jones RS, Focant JF, Lapeza C, Wang RY, McGahee EE, Zhang YL, Turner WE, Slazyk B, Needham LL, Patterson DG Jr (2004) Retrospective timetrend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States. Environ Health Perspect 112:654–658
Thomsen C, Stigum H, Froshaug M, Broadwell SL, Becher G, Eggesbo M (2010) Determinants of brominated flame retardants in breast milk from a large scale Norwegian study. Environ Int 36:68–74
U.S. EPA (2002) Child: specific exposure factor handbook. http://fn.cfs.purdue.edu/fsq/WhatsNew/KidEPA.pdf
U.S. EPA (2008a) U.S. Environmental Protection Agency. 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47). http://www.epa.gov/iris/subst/1010.htm
U.S. EPA (2008b) U.S. Environmental Protection Agency. 2,2′,4,4′,5,5′-Hexabromodiphenyl ether (BDE-153). http://www.epa.gov/iris/subst/1009.htm
U.S. EPA (2008c) U.S. Environmental Protection Agency. 2,2′,3,3′,4,4′,5,5′,6,6′-Decabromodiphenyl ether (BDE-209). http://www.epa.gov/iris/subst/0035.htm
Viberg H, Johansson N, Fredriksson A, Eriksson J, Marsh G, Eriksson P (2006) Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice. Toxicol Sci 92:211–218
Xia J, Wang LJ, Luo HA (2005) Present status and developing tendency of flame retardant. Appl Chem Ind 34:1–3 (in chinese)
Xian QM, Karri R, Tomohiko I, Agus S, Liu XH, Gao ZS, Shin T, Yu HX, Shinsuke T (2008) Levels and body distribution of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) in freshwater fishes from the Yangtze River, China. Chemosphere 71:268–276
Zhang JG, Sun XW, Ai H (2012) Levels and congener profiles of polybrominated diphenyl ethers (PBDEs) in primipara breast milk from Shenzhen and exposure risk for breast-fed infants. J Environ Monit 14:893–900
Zhao YF, Zhang R, Zhang L, Li JG, Wu YN, Shen JZ (2010) Polybrominated dipenyl ethers (PBDEs) in breast milk samples from Beijng in 2007. J Hyg Res 39:326–330
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This work was supported by a Grant (Science and Technology Project of Hebei Province, China 16275510D). We wish to thank all the milk donors and the hospital staff for sample collection in this study.
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Yang, L., Lu, Y., Wang, L. et al. Levels and Profiles of Polybrominated Diphenyl Ethers in Breast Milk During Different Nursing Durations. Bull Environ Contam Toxicol 97, 510–516 (2016). https://doi.org/10.1007/s00128-016-1908-2
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DOI: https://doi.org/10.1007/s00128-016-1908-2


