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Geno- and Cyto-toxicity in Free-Living Rodent Mus spretus Exposed to Simulated Onshore Oil Spill


This study investigated geno- and cyto-toxic damage in the free-living rodent, Mus spretus after exposure to a simulated spill of crude oil on soil. The results revealed increased mutagenicity and cytotoxicity in bone marrow cells and increased DNA damage in blood cells. Exposure to crude oil increased sperm abnormalities, with lasso-like folds being the most common. These results point to the value of this rodent in serving as a sentinel species for the monitoring and prediction of environmental hazards.

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The authors thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, for the doctoral scholarships (DS and PDEE) granted to F.M.R. Da Silva Júnior.

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Correspondence to Flavio Manoel Rodrigues da Silva Júnior.

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da Silva Júnior, F.M.R., Monarca, R.I., Dias, D. et al. Geno- and Cyto-toxicity in Free-Living Rodent Mus spretus Exposed to Simulated Onshore Oil Spill. Bull Environ Contam Toxicol 91, 465–468 (2013).

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  • Wild rodents
  • Sentinels species
  • Crude oil
  • Sperm abnormality
  • Comet assay
  • Micronucleus test