Abstract
Estrogenic effects of individual chemicals and mixtures of 17β-estradiol (E2) and o,p′-DDT were examined using pS2 and PR gene expressions in MCF-7 cells. Interactions between E2 and o,p′-DDT were evaluated by a statistical method based on factorial design. At levels close to environmentally realistic concentrations, no significant interactions between E2 and o,p′-DDT were observed, suggesting that the xenoestrogen (o,p′-DDT) could act in an additive way with the endogenous estrogen (E2). These results demonstrated the utility of this statistical method in a mixture study, and highlight the potential interference and health risk of low-level xenoestrogens, such as o,p′-DDT.
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (20977062 and 31071860), the project of Science and Technology Commission of Shanghai Municipality, China (11ZR1435600, 10410705800), the National High-Tech Research and Development Plan (2012AA101405) and the Special Fund for Agro-scientific Research in the Public Interest of China (200903056).
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Zhong, L., Xiang, X., Lu, W. et al. Interference of Xenoestrogen o,p′-DDT on the Action of Endogenous Estrogens at Environmentally Realistic Concentrations. Bull Environ Contam Toxicol 90, 591–595 (2013). https://doi.org/10.1007/s00128-013-0976-9
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DOI: https://doi.org/10.1007/s00128-013-0976-9