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Sodium Sulfite Enhances Rhinovirus-Induced Chemokine Production in Airway Epithelial Cells

Abstract

We investigated the effects of sodium sulfite (Na2SO3) on rhinovirus (RV)-induced chemokine production in A549 airway epithelial cells. Our results demonstrated that the treatment of A549 cells with 2,500 μM Na2SO3 enhanced the mRNA expression of RV-induced interleukin (IL)-8 1.8 fold (p = 0.025); and regulated on activation, normal T cell expressed and secreted (RANTES), 2.9 fold (p = 0.025). Moreover, the secretion of IL-8, RANTES, and interferon-γ-inducible protein (IP)-10 was increased in a statistically significant manner without affecting cell viability and RV replication. Our results suggest that Na2SO3 may potentiate RV infection by enhancing chemokine production.

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Acknowledgments

This work was supported by a Korea Research Foundation (KRF) grant, funded by the Korean Government (MEST) (No. 2009-0066649) and by Seoul St. Mary’s Clinical Medicine Research Program (2009) through the Catholic University of Korea.

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Correspondence to Jong-seo Yoon.

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Chun, Y.H., Kim, H.S., Lee, H. et al. Sodium Sulfite Enhances Rhinovirus-Induced Chemokine Production in Airway Epithelial Cells. Bull Environ Contam Toxicol 89, 718–722 (2012). https://doi.org/10.1007/s00128-012-0786-5

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Keywords

  • Sodium sulfite
  • Rhinovirus
  • Chemokines
  • Epithelial cells