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Chloramphenicol Residues in Muscle of Rainbow Trout Following Two Different Dose Treatments

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Abstract

Depletion of chloramphenicol (CAP) in muscle of rainbow trout was evaluated following 4 days of oral administration with two dosages (42 and 84 mg/kg/day). Sampling was conducted during treatment and for 35 days following the end of treatment. Analysis was carried out using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Concentrations observed during treatment were more than 300 μg/kg. A significant elimination occurred within 9 days after the cessation of treatment in both groups. Higher CAP levels were measured in the group treated with higher dose. CAP was not detectable after 13 and 15 after the end of treatment in both groups.

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Acknowledgments

The Authors would like to thank Mirjana Hren and Tamara Nekić for the activity of sample preparation.

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Authors and Affiliations

  1. Laboratory for Residue Control, Department of Veterinary Public Health, Croatian Veterinary Institute, Savska cesta 143, HR-10000, Zagreb, Croatia

    Nina Bilandžić, Ivana Varenina & Božica Solomun Kolanović

  2. Veterinary Office of Bosnia and Herzegovina, Radićeva 8, 71000, Sarajevo, Bosnia and Herzegovina

    Sanin Tanković

  3. Department for Food Hygiene and Technology, Faculty of Veterinary Medicine, University of Sarajevo, Zmaja od Bosne 90, 71000, Sarajevo, Bosnia and Herzegovina

    Muhamed Smajlović

Authors
  1. Nina Bilandžić
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  2. Sanin Tanković
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  3. Ivana Varenina
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  4. Božica Solomun Kolanović
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  5. Muhamed Smajlović
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Correspondence to Nina Bilandžić.

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Bilandžić, N., Tanković, S., Varenina, I. et al. Chloramphenicol Residues in Muscle of Rainbow Trout Following Two Different Dose Treatments. Bull Environ Contam Toxicol 89, 461–466 (2012). https://doi.org/10.1007/s00128-012-0711-y

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  • DOI: https://doi.org/10.1007/s00128-012-0711-y

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