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Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice

Abstract

This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87; 2.84 ± 0.22 Units/mg protein respectively) and catalase (4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein respectively) activities were significantly (p < 0.05) elevated in “parasitized and treated” (PnT) animals. Renal glutathione level (19.02 ± 0.20 μg/mL) was elevated in PnT animals. Glutathione S-transferase and malondialdehyde levels in hepatic (8.76 ± 0.49 μmol/min/mg; 527.23 ± 24.56 mmol/dL) and renal (3.35 ± 0.30 μmol/min/mg; 464.42 ± 59.13 mmol/dL) tissues were significantly high (p < 0.05) in coartemether-treated animals alone. Plasma aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase (5.78 ± 2.36 U/L) were high in PnT animals. Therefore, data indicates that in the presence of P. berghei, coartemether could alter the antioxidant status and induce hepatotoxic damage in mice.

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Acknowledgments

We express gratitude to Babcock University Administration for their support. We are grateful to the Head of Department of Chemical and Environmental Sciences, Babcock University Prof. E. B. Esan for constant encouragement, support and critique of the manuscript. Our appreciation goes to Anyasor Chiamaka O. for typesetting and editing of the manuscript. We declare no conflict of interest and are solely responsible for the writing and content of this work.

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Correspondence to God’swill Nduka Anyasor.

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Anyasor, G.N., Oyewole, I.O., Ogunwenmo, K.O. et al. Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice. Bull Environ Contam Toxicol 88, 108–111 (2012). https://doi.org/10.1007/s00128-011-0460-3

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Keywords

  • Antioxidant
  • Tissues
  • Mice
  • Plasmodium berghei