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Neurodevelopment of Infants with Prenatal Exposure to Polybrominated Diphenyl Ethers

Abstract

The study aimed to examine the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on infant neurodevelopment. PBDEs levels in 36 cord blood samples were analyzed with a high-resolution-gas-chromatograph/high-resolution-mass-spectrometer and infant neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. The mean and median of Σ11PBDEs were 6.63 and 4.63 ng/g lipid, respectively. As compared to the lower PBDEs group (Σ11PBDEs < 4.63 ng/g lipid), the higher PBDEs group (Σ11PBDEs > 4.63 ng/g lipid) had a significantly higher actual odds ratio (OR = 1.13, p < 0.05) of the cognition score as well as a lower odds ratio (OR = 0.904, p < 0.01) of the adaptive behavior score, suggesting that prenatal PBDEs exposure may potentially affect infant neurodevelopment.

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Acknowledgments

This work was supported by grants from the National Science Council (NSC 96-2628-E-020-001-MY3) and the National Health Research Institutes (EO-099-PP-03, EO-100-PP-03) in Taiwan. The authors declare that there are no conflicts of interest.

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Correspondence to How-Ran Chao or Tsui-Chun Tsou.

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Shy, CG., Huang, HL., Chang-Chien, GP. et al. Neurodevelopment of Infants with Prenatal Exposure to Polybrominated Diphenyl Ethers. Bull Environ Contam Toxicol 87, 643–648 (2011). https://doi.org/10.1007/s00128-011-0422-9

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Keywords

  • Polybrominated diphenyl ethers (PBDEs)
  • Cord blood
  • Infants
  • Neurodevelopment
  • Bayley scale of infants and toddlers development