The study aimed to examine the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on infant neurodevelopment. PBDEs levels in 36 cord blood samples were analyzed with a high-resolution-gas-chromatograph/high-resolution-mass-spectrometer and infant neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. The mean and median of Σ11PBDEs were 6.63 and 4.63 ng/g lipid, respectively. As compared to the lower PBDEs group (Σ11PBDEs < 4.63 ng/g lipid), the higher PBDEs group (Σ11PBDEs > 4.63 ng/g lipid) had a significantly higher actual odds ratio (OR = 1.13, p < 0.05) of the cognition score as well as a lower odds ratio (OR = 0.904, p < 0.01) of the adaptive behavior score, suggesting that prenatal PBDEs exposure may potentially affect infant neurodevelopment.
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This work was supported by grants from the National Science Council (NSC 96-2628-E-020-001-MY3) and the National Health Research Institutes (EO-099-PP-03, EO-100-PP-03) in Taiwan. The authors declare that there are no conflicts of interest.
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Shy, CG., Huang, HL., Chang-Chien, GP. et al. Neurodevelopment of Infants with Prenatal Exposure to Polybrominated Diphenyl Ethers. Bull Environ Contam Toxicol 87, 643–648 (2011). https://doi.org/10.1007/s00128-011-0422-9
- Polybrominated diphenyl ethers (PBDEs)
- Cord blood
- Bayley scale of infants and toddlers development