To test whether the dose addition and independent action models can predict the combined toxicity of the mixtures of phenol and aniline derivatives, six phenolic and two aniline derivatives were selected as the test components. The inhibition toxicity of the derivatives and their mixtures to Vibrio qinghaiensis sp.-Q67 indicated that all dose–response relationships could be effectively described by the Weibull function with correlation coefficients greater than 0.99. The combined toxicity of two equivalent-effect concentration ratio mixtures and eight uniform design concentration ratio mixtures could be predicted successfully by the dose addition model within 95% confidence intervals. However, it was also well predicted by the independent action model, especially at lower concentrations.
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The manuscript has greatly benefited from insightful comments by the associate editor and an anonymous reviewer. The authors are especially grateful to the financial support from the Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), the Ministry of Education, China (Grant No.1002K001), the National Natural Science Foundation of China (Grant No. 20777056/B0705) and the Provincial Natural Science Foundation of Guangxi (GuiKeZi 2011GXNSFF018003).
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Mo, LY., Liu, SS., Zhu, YN. et al. Combined Toxicity of the Mixtures of Phenol and Aniline Derivatives to Vibrio qinghaiensis sp.-Q67. Bull Environ Contam Toxicol 87, 473 (2011). https://doi.org/10.1007/s00128-011-0374-0
- Phenol derivative
- Aniline derivative
- Vibrio qinghaiensis
- Combined toxicity