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Mycotoxin Detection in Urine Samples from Patients with Chronic Kidney Disease of Uncertain Etiology in Sri Lanka

Abstract

This was a screening study that aimed to determine the presence of nephrotoxic mycotoxins in urine samples from patients with chronic kidney disease of uncertain etiology in the North Central Province of Sri Lanka. The percentage detection of aflatoxins, ochratoxins and fumonisins in 31 patients were 61.29%, 93.5% and 19.4%, respectively. Geometric means of urinary aflatoxins and ochratoxins were 30.93 creatinine and 34.62 ng/g creatinine in chronic kidney disease of uncertain etiology stage 1–2 patients and 84.12 ng/g creatinine and 63.52 ng/g creatinine in unaffected relatives of patients. In chronic kidney disease of uncertain etiology stage 3–5 patients, geometric means of urinary aflatoxins and ochratoxins were 10.40 and 17.08 ng/g creatinine, respectively. Non-affected relatives of patients (n = 6) had comparable levels of these mycotoxins, but healthy Japanese individuals (n = 4) had lower levels than in Sri Lanka. The higher detection rate of urinary ochratoxins in Sri Lankans indicates that exposure is common in the region.

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Acknowledgments

This work was supported by special coordination funds for promoting science and technology sponsored by the Japan Science and Technology Agency. The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare that they have no competing interests.

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Correspondence to Akio Koizumi.

Additional information

This study is conducted for the Chronic Kidney Disease of Uncertain Etiology Consortium.

Please refer the Appendix section for the full list of members.

Appendix

Appendix

 

Nation Collaborative institutes Members
Sri Lanka Faculty of Science, University of Peradeniya Rohana Chandrajith (CP)
Ayanthi Navarathna
Faculty of Medicine, University of Peradeniya N. Ratnatunga
Dhammika Dissanayake
Nimmi Aturaliya
K. Jayasekara
Ministry of Health and Nutrition [GH Kandy (Teaching), District Hospital Medawachchiya, District Hospital Girandurukotte] Tilak Abeysekara
A.W.M. Wazeel
Upul Karunaratne
KU Senaviratne
EDL Gunaratne
Institute of Fundamental Studies (IFS) C.B. Dissanayake
J.P. Padmasiri
  C.M. Madduma Bandara
Japan Department of Health and Environmental Sciences, Kyoto University Akio Koizumi (PI)
Kouji Harada
Toshiaki Hitomi
Shanika Nanayakkara
Lalantha Senevirathna
Kitano Hospital Eri Muso
Toshiyuki Komiya
Yoshiaki Yuba
Tohoku Bunkyo University Takao Watanabe
Daiichi Pharmaceutical University Koichi Haraguchi
Australia University of Qeensland Wendy Hoy
Glenda Gobe
Susan Mott

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Desalegn, B., Nanayakkara, S., Harada, K.H. et al. Mycotoxin Detection in Urine Samples from Patients with Chronic Kidney Disease of Uncertain Etiology in Sri Lanka. Bull Environ Contam Toxicol 87, 6 (2011). https://doi.org/10.1007/s00128-011-0301-4

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Keywords

  • Chronic kidney disease of uncertain etiology
  • Sri Lanka
  • Urine sample
  • Aflatoxin
  • Ochratoxin
  • Fumonisin