The widespread use of the pharmaceutical chlortetracycline to treat human and animal infectious diseases is raising concern in Korea regarding the potential development of antibiotic-resistant bacteria. This study investigated the fate of chlortetracycline in Korean arable soils, to assess its environmental impact. The estimated half-life of chlortetracycline was 26.70–27.17 days indoors and 18.63–30.16 days outdoors. The chlortetracycline epimers and metabolites, 4-epichlortetracycline and 4-epi-anydrochlotetracycline were determined using liquid chromatography tandem mass spectroscopy. The respective concentrations of 4-epi-anydrochlotetracycline and 4-epichlortetracycline were 1.91%–9.71% and 11.12%–23.92% of the total chlortetracycline residual concentration indoors and 2.96%–11.44% and 17.61%–40.73% outdoors.
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This study was funded by grant from the IAEA Research Contract No. 15578/R0 (CRP) and NVRQS Research Work B-FS08-2009-10-02.
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Kwon, JW. Fate of Chlortetracycline in Korean Arable Soil. Bull Environ Contam Toxicol 87, 36 (2011). https://doi.org/10.1007/s00128-011-0298-8
- Korean arable soil