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Mobility of Veterinary Drugs in Soil with Application of Manure Compost


Sulfonamides and tetracyclines are pharmaceuticals widely used to treat human and animal diseases. They are of considerable concern in Korea because of the potential risk of residues in aquatic and terrestrial environments. This study investigated the mobility of veterinary drugs in the soil column with the application of manure compost to assess the risk of groundwater contamination by leaching in the Korean agricultural environment. The degree of sulfonamides and tetracyclines mobility, measured by the concentration of leachates from silty loam soil for 9 days, was observed being on the first day of this study, in the order sulfathiazole, sulfamethazine > sulfamethoxazole > chlortetracycline > oxytetracycline, and the sulfonamides concentrations were about ten times higher than the tetracyclines concentrations with continuous leaching. The results indicate that sulfonamides pose a high risk of ground and surface water contamination and tetracyclines have the potential to persist in soils with bioactive epimers.

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  1. Berger K, Petersen B, Büning-Pfaue H (1986) Persistenz von Arzneimitteln aus Gülle in der Nahrungskette. Archiv Lebensmittelhyg 37:99–102

    Google Scholar 

  2. Halling-Sørens B (2001) Inhibition of aerobic growth and nitrification of bacteria in sewage sludge by antibacterial agents. Arch Environ Contam Toxicol 40:9–11

    Google Scholar 

  3. Halling-Sørensen B, Sengeløv G, Tjørnelund J (2002) Toxicity of tetracyclines and tetracycline degradation products to environmental relevant bacteria, including selected tetracycline-resistant bacteria. Arch Environ Contam Toxicol 42:263–271

    Article  Google Scholar 

  4. Hirsch R, Ternes T, Haberer K, Kratz KL (1999) Occurrence of antibiotic in the aquatic environment. Sci Total Environ 225:109–118

    Article  CAS  Google Scholar 

  5. Kay P, Blackwell PA, Boxall ABA (2005a) A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. Environ Pollut 134:333–341

    Article  CAS  Google Scholar 

  6. Kay P, Blackwell PA, Boxall ABA (2005b) Transport of veterinary antibiotics in overland flow following the application of slurry to arable land. Chemosphere 59:951–959

    Article  CAS  Google Scholar 

  7. Kay P, Blackwell PA, Boxall ABA (2005c) Column studies to investigate the fate of veterinary antibiotics in clay soils following slurry application to agricultural land. Chemosphere 60:497–507

    Article  CAS  Google Scholar 

  8. Kümmerer K (2001) Pharmaceuticals in the environment. Springer, Berlin

    Google Scholar 

  9. Langhammer JP, Büning-Pfaue H (1989) Bewertung von Arzneistoff-Rückständen aus der Gülle im Boden. Lebensmittelchem Gerichtl Chem 43:103–113

    Google Scholar 

  10. Lynch MR (ed) (1995) Procedures for assessing the environmental fate and ecotoxicity of pesticides. SETAC, Brussels

    Google Scholar 

  11. Martínez-Carballo E, Gonza′lez-Barreiro C, Scharf S, Gans O (2007) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environ Pollut 148:570–579

    Article  Google Scholar 

  12. NIER (2007) Development of analytical method and the study of exposure of pharmaceuticals and personal care products in environment (II), National Institute of Environmental Research, Republic of Korea

  13. Sukul P, Spiteller M (2006) Sulfonamides in the environment as veterinary drugs. Rev Environ Contam Toxicol 187:67–101

    Article  CAS  Google Scholar 

  14. Thiele-Bruhn S, Seibicke T, Schulten H-R, Leinweber P (2004) Sorption of sulfonamide pharmaceutical antibiotics on whole soils and particle-size fractions. J Environ Qual 33:1331–1342

    Article  CAS  Google Scholar 

  15. Tolls J (2001) Sorption of veterinary pharmaceuticals in soils: a review. Environ Sci Technol 35(17):3397–3406

    Article  CAS  Google Scholar 

  16. US EPA (1985) Pesticide assessment guidelines, subdivision N, chemistry: environmental fate, series 163–1: soil column leaching studies. US EPA Hazard Evaluation Division, Office of Pesticide Programs, EPA-540/9-85-017

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This study was funded by grant from the IAEA Research Contract No. 15578/R0 (CRP) and NVRQS Research Work B-FS08-2009-10-02.

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Correspondence to Jin-Wook Kwon.

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Kwon, JW. Mobility of Veterinary Drugs in Soil with Application of Manure Compost. Bull Environ Contam Toxicol 87, 40 (2011).

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  • Mobility
  • Sulfonamides
  • Tetracyclines
  • Soil column
  • Leaching