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Seventeen-Year Observation on Urinary Cadmium and β2-Microglobulin in Inhabitants After Cessation of Cadmium-Exposure in Japan


The purpose of this study was to clarify the change and relationship of urinary cadmium (Cd) and β2-microglobulin (β2-MG) concentrations of inhabitants in Cd-polluted areas after soil restoration. The urinary Cd and β2-MG concentrations of 25 males and 28 females did not show a significant change, 22 years after the Cd-polluted soil was restored. Once exposed to Cd, it was found to remain in the body, 22 years after the Cd -polluted soil was restored. However, this did not influence renal tubular dysfunction in most of the younger generation compared with elders heavily exposed to Cd.

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  1. Aoshima K, Kasuya M (1993) Itai-Itai disease–a natural history of osteomalacia caused by urinary tubular dysfunction during exposure to general environmental cadmium. J Med Treat 75:1031–1035 (in Japanese)

    Google Scholar 

  2. Aoshima K, Iwata K, Kasuya M (1988) Environmental exposure to cadmium and effects on human health part 1. Renal tubular function in inhabitants of the cadmium-polluted Jinzu River basin in Toyama Prefecture. Jap J Hyg 43:853–863 (Abstract in English)

    Google Scholar 

  3. Cai Y, Aoshima K, Katoh T, Teranishi H, Kasuya M (2001) Renal tubular dysfunction in male inhabitants of cadmium-polluted area in Toyama, Japan-an eleven-year follow-up study. J Epidemiol 11(4):180–189

    CAS  Google Scholar 

  4. Friberg L (1985) Cadmium and health. CRC Press, Boca Raton, pp 1–5

    Google Scholar 

  5. Honda R, Yamada Y, Tsurutani I, Kobayashi E, Ishizaki M, Nogawa K (1982) Significance of low molecular proteinuria in cadmium poisoning. Kanazawa Medical University J 7(3):142–151 (Abstract in English)

    CAS  Google Scholar 

  6. Honda R, Tsurutani I, Ishizaki M, Kido T, Yamada Y, Nogawa K (1989) Flaméeles atomic absorption spectrophotometry of cadmium and lead in blood and urine. Kanazawa Medical University J 14(3):337–347 (Abstract in English)

    CAS  Google Scholar 

  7. Ishikawa Prefecture (1975) In measurement of soil in farmlands of polluted areas, Ishikawa prefecture laws and regulations. ( (in Japanese)

  8. Ishikawa Prefecture South Kaga Public Health Center (1997) Research and induction about local health and environment during 9 Heisei years. Report in Ishikawa Prefecture South Kaga Public Health 4:82 (in Japanese)

  9. Iwata K, Saito H, Moriyama M, Nakano A (1993) Renal tubular function after reduction of environmental cadmium exposure: a ten-year follow-up. Arch Environ Health 48(3):157–163

    CAS  Google Scholar 

  10. Kasuya M (1985) Liver injury by cadmium. KanTan Sui 10:923–928 (in Japanese)

    CAS  Google Scholar 

  11. Kido T (1995) Studies on health effects of cadmium exposure in the general environment. Jap J Hyg 49(6):960–972

    CAS  Google Scholar 

  12. Kido T, Honda R, Tsuritani I, Yamaya H, Ishizaki M, Yamada Y, Nogawa K (1988) Progress of renal dysfunction in inhabitants environmentally exposed to cadmium. Arch Environ Health 43(3):213–217

    CAS  Google Scholar 

  13. Kido T, Nishijo M, Nakagawa H, Kobayashi E, Nogawa K, Tsuritani I et al (2001) Urinary finding of inhabitants in a cadmium-polluted area ten years after cessation of cadmium exposure. Hokuriku J Public Health 27(2):1–4

    Google Scholar 

  14. Kido T, Naganuma R, Takasaki I, Nishijo M, Nakagawa H, Kobayashi E, Nogawa K (2002) Eighteen years observation of renal function in inhabitants exposure to cadmium in Kakehashi River basin, Ishikawa Prefecture. Environ Health Report 66:336–339 (Abstract in English)

    Google Scholar 

  15. Kubota Y, Teranishi H, Aoshima K, Kato T, Nishijo M, Kasuya M (1985) A study on normal range of urinary protein fraction concentrations, albumim, β2-microglobulin and α1-microglobulin among community inhabitants. Hokuriku J Pub Health 12:27–32 (Abstract in English)

    Google Scholar 

  16. Matsunami J (2006) Review of Itai-Itai disease. Katsura Syobou, Toyama, pp 2–38. (in Japanese)

  17. Nakagawa H, Nishijo M (1999) Dose-response relationship and mortality in inhabitants of cadmium polluted areas. Advance in Prevention of Environmental Cadmium Pollution and Countermeasures. Eiko Laboratory, Kanazawa, pp 31–34

    Google Scholar 

  18. Nogawa K, Ishizaki A, Kawano S (1978) Statistical observation of the dose-response relationship of cadmium based on epidemiological studies in the kakehasi river basin. Env Res 15:185–198

    Article  CAS  Google Scholar 

  19. Nogawa K, Yamada Y, Honda R, Ishizaki A, Tsuritani I, Ishizaki M, Sakamoto M (1983) Urinary N-acetyl-β-D-glucosaminidase and β2-microglobulin in ‘itai-itai’ disease. Toxicol Lett 16:317–322

    Article  CAS  Google Scholar 

  20. Nordberg GF, Kjellstrom T, Nordberg M (1985) Cadmium and health. A toxicological and epidemiological appraial. CRC Press, Boca Raton, p 6

    Google Scholar 

  21. Saito H, Takebayashi S, Harada K, Hara K, Iwata K, Segawa S (1993) Chronic cadmium poisoning. Nagasaki University (second internal medicine), Nagasaki, pp 54–117. (in Japanese)

  22. Suwazono Y, Kobayashi E, Okubo Y, Nogawa K, Kido T, Nakagawa H (2000) Renal effects of cadmium exposure in cadmium non-polluted areas in Japan. Env Res Sec A 84:44–55

    Article  CAS  Google Scholar 

  23. Tsuchiya K (1978) Cadmium studies in Japan: a review. Kodansha, Tokyo, pp 171–220

  24. Wada T (1986) Metals and humans. Asakura publishers, Tokyo, p 246

    Google Scholar 

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The authors thank the inhabitants of the Kanehira area, who had to endure physical examinations over a period of 17 years. Also, we sincerely wish the inhabitants of the Kanehira area good health and long lives.

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Correspondence to Reiko Sato.

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Sato, R., Kido, T., Honda, R. et al. Seventeen-Year Observation on Urinary Cadmium and β2-Microglobulin in Inhabitants After Cessation of Cadmium-Exposure in Japan. Bull Environ Contam Toxicol 84, 363–367 (2010).

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  • Urinary-Cadmium
  • Urinary-β2-Microglobulin
  • Biological half life
  • Soil restoration