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Tamoxifen Affects the Toxicokinetics of o,p′-DDT in Male Nile Tilapia (Oreochromis niloticus)

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Abstract

The goal of the present study was to evaluate the role of Tamoxifen (TAM), in the distribution and/or elimination kinetics of o,p′-DDT, in male tilapias. A non-compartmental analysis was chosen to describe the time course of o,p′-DDT plasma concentrations. Mean plasma concentration of o,p′-DDT following IP administration indicates a very complex kinetic profile. Tamoxifen decreased the o,p′-DDT mean half-life (t½) from 20.38 to 16.11 days, the Mean Residence Time (MRT) from 28.7 to 23.23 days, and clearance (CL) from 0.0031 to 0.001 mL/min. The distribution pattern of o,p′-DDT in tissues and the clearance in plasma suggest that storage points mediated through the membrane-receptor lipophilicity can be involved.

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Authors and Affiliations

  1. Departmento de Recursos del Mar, Cinvestav del IPN, Km 6 Antigua Carretera a Progreso, Yucatán, C.P. 97310, Merida, Mexico

    María del Rocío Barreto-Castro, Lisbeth Enith Gómez-Martínez & Gerardo Gold-Bouchot

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  1. María del Rocío Barreto-Castro
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  2. Lisbeth Enith Gómez-Martínez
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  3. Gerardo Gold-Bouchot
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Correspondence to Gerardo Gold-Bouchot.

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del Rocío Barreto-Castro, M., Gómez-Martínez, L.E. & Gold-Bouchot, G. Tamoxifen Affects the Toxicokinetics of o,p′-DDT in Male Nile Tilapia (Oreochromis niloticus). Bull Environ Contam Toxicol 85, 545–549 (2010). https://doi.org/10.1007/s00128-010-0139-1

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  • DOI: https://doi.org/10.1007/s00128-010-0139-1

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