Correlation Between Pesticide Use in Agriculture and Adverse Birth Outcomes in Brazil: An Ecological Study

  • Marília Teixeira de Siqueira
  • Cynthia Braga
  • José Eulálio Cabral-Filho
  • Lia Giraldo da Silva Augusto
  • José Natal Figueiroa
  • Ariani Impieri Souza
Article

Abstract

This ecological study analyzed the association between pesticide use and prematurity, low weight and congenital abnormality at birth, infant death by congenital abnormality, and fetal death in Brazil in 2001. Simple linear regression analysis has determined a positive association between pesticide use and prematurity, low birth weight, and congenital abnormality. The association between pesticide use and low birth weight (p = 0.045) and, congenital abnormality (p = 0.004) and infant death rate by congenital abnormality (p = 0.039) remained after the adjustment made by the proportion of pregnant women with a low number of prenatal care visits.

Keywords

Pesticides Birth weight Preterm birth Birth defect 

References

  1. Agencia Nacional de Vigilancia Sanitaria (2005) Nota tecnica sobre livre comercio de agrotoxicos e impactos a saude humana. Available http://www.anvisa.gov.br. Accessed 10 March 2008
  2. Agencia Nacional de Vigilancia Sanitaria (2009) Nota Tecnica para divulgaçao dos resultados do Programa de Analise de Residuos de Agrotoxicos em Alimentos—PARA de 2008. Available http://www.anvisa.gov.br. Accessed 10 May 2009
  3. Bell EM, Hertz-Picciotto I, Beaumout JJ (2001) A case-control study of pesticides and fetal death due to congenital anomalies. Epidemiology 12:148–156CrossRefGoogle Scholar
  4. Dolk H, Vrijheid M, Armstrong B, Abramsky L, Bianchi F, Garne E et al (1998) Risk of congenital anomalies near hazardous-waste landfill sites in Europe: EUROHAZCON study. Lancet 352:423–427CrossRefGoogle Scholar
  5. Fenster L, Eskenazi B, Anderson M, Bradman A, Harley K, Hernandez H (2006) Association of in utero organochlorine pesticide exposure and fetal death and length of gestation in an agricultural population. Environ Health Perspect 114:597–602CrossRefGoogle Scholar
  6. Kageyama A (2003) Produtividade e renda na agricultura familiar: efeitos do PRONAF crédito. Agric Sao Paulo 50:1–13Google Scholar
  7. Longnecker MP, Klefanoff MA, Dunson DB (2005) Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies. Environ Res 97:126–132CrossRefGoogle Scholar
  8. Ministerio da Agricultura, Pecuaria e Abastecimento (2005) Agricultura Brasileira em Numeros: Anuario 2005. Available http://www.agricultura.gov.br. Accessed 25 August 2008
  9. Ministerio da Saude (2001a) Informaçoes de Saude. Estatisticas vitais: mortalidade. Available http://tabnet.datasus.gov.br. Accessed 14 June 2007
  10. Ministerio da Saude (2001b) Informaçoes de Saude. Estatisticas vitais: nascidos vivos. Available http://tabnet.datasus.gov.br. Accessed 14 June 2007
  11. Ministerio do Planejamento, Orçamento e Gestao (2002) Indicadores de desenvolvimento sustentavel: dimensao ambiental—Terra. Rio de Janeiro: IBGE. Available http://www.ibge.gov.br/home. Accessed 25 August 2008
  12. Nurminen T (1995) Maternal pesticide exposure and pregnancy. JOEM 37:935–940Google Scholar
  13. Peiris-John RJ, Wickremasinghe R (2008) Impact of low-level exposure to organophosphates on human reproduction and survival. Trans R Soc Trop Med Hyg 102:239–245CrossRefGoogle Scholar
  14. Perera FP, Rauh V, Tsai WY, Kinney P, Camann D, Barr D et al (2003) Effects of transplacental exposure to environmental polluants on birth outcomes in a multiethnic population. Environ Health Perspect 11:201–205Google Scholar
  15. Thulstrup AM, Bonde JP (2006) Maternal occupational exposure and risk of specific birth defects. Occup Med 56:532–543CrossRefGoogle Scholar
  16. Waissmann W (2007) Agrotoxicos e doenças nao transmissiveis. Cien Saude Colet 12:20–21Google Scholar
  17. Whyatt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, Hoepner LA, Diaz D, Dietrich J, Reys A, Tang D, Kinney PL, Perera FP (2004) Prenatal insecticide exposures and birth weigth and length among an urban minority cohort. Environ Health Perspect 112:1125–1132CrossRefGoogle Scholar
  18. Woodruff TJ, Carlson A, Schwartz MJ, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89:281–300CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Marília Teixeira de Siqueira
    • 1
    • 2
    • 3
  • Cynthia Braga
    • 1
    • 4
  • José Eulálio Cabral-Filho
    • 1
  • Lia Giraldo da Silva Augusto
    • 2
    • 4
  • José Natal Figueiroa
    • 1
  • Ariani Impieri Souza
    • 1
  1. 1.Instituto de Medicina Integral Prof. Fernando FigueiraRecifeBrazil
  2. 2.Faculdade de Ciencias MedicasUniversidade de PernambucoRecifeBrazil
  3. 3.Secretaria de Saude do Estado de PernambucoRecifeBrazil
  4. 4.Centro de Pesquisa Aggeu MagalhaesFundaçao Oswaldo CruzRecifeBrazil

Personalised recommendations